Effect of Roux-en-Y gastric bypass surgery on intestinal Akkermansia muciniphila

doi:10.4240/wjgs.v8.i4.301

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 8, Issue 4

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (10025)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-2) series, Tables (1-5) series.

Item

Count

PDF

674

WORD

243

HTML

4035

Figures (1-2)

218

Tables (1-5)

351

Sum=5521

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

475

Download

1110

Sum=1585

Publishing Process of This Article

Item

Count

Browse

1054

Download

1865

Sum=2919

Apr 27, 2016 (publication date) through Nov 29, 2024

Times Cited of This Article

Times Cited (24)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Surgery

ISSN

1948-9366

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastrointest Surg. Apr 27, 2016; 8(4): 301-307
Published online Apr 27, 2016. doi: 10.4240/wjgs.v8.i4.301

Table 1 Fasting blood glucose in different groups before and after surgery (x ± s, mmol/L)

Time point	GK-RYGB	GK-Sham	WS-Sham
1 wk presurgery	6.98 ± 0.32^a	7.07 ± 0.57^a	4.57 ± 0.26
1 wk postsurgery	6.42 ± 0.25^c	6.82 ± 0.49^a	4.25 ± 0.23
2 wk postsurgery	6.01 ± 0.20^a^c^e	6.88 ± 0.52^a	4.37 ± 0.22
3 wk postsurgery	5.60 ± 0.26^a^c^e	6.93 ± 0.52^a	4.37 ± 0.23
4 wk postsurgery	5.72 ± 0.25^a^c^e	7.03 ± 0.52^a	4.50 ± 0.24

^aP < 0.05 vs WS-Sham group;

^cP < 0.05 vs GK-Sham group;

^eP < 0.05 vs presurgery value. GK: Goto-Kakizaki; RYGB: Roux-en-Y gastric bypass; WS: Wistar.

Table 2 Serum insulin in different groups before and after surgery (x ± s, pmol/L)

Group	Presurgery		4 wk postsurgery
Group	Fasting	30 min after intragastric glucose	Fasting	30 min after intragastric glucose
GK-RYGB	15.20 ± 0.67^a	27.07 ± 1.07^a	16.05 ± 1.41^a	47.57 ± 4.24^a^c
GK-Sham	15.26 ± 0.76^a	27.49 ± 1.29^a	15.43 ± 0.97^a	27.26 ± 1.26^a
WS-Sham	18.54 ± 0.99	104.00 ± 4.96	19.01 ± 0.42	103.68 ± 4.85

^aP < 0.05 vs WS-Sham group;

^cP < 0.05 vs GK-Sham group. GK: Goto-Kakizaki; RYGB: Roux-en-Y gastric bypass; WS: Wistar.

Table 3 Homeostasis model assessment-insulin resistance in different groups before and after surgery

Group	Presurgery	4 wk postsurgery
GK-RYGB	4.72 ± 0.34^a	4.07 ± 0.30^c^e
GK-Sham	4.80 ± 0.51^a	4.83 ± 0.54
WS-Sham	3.75 ± 0.07	3.74 ± 0.20

^aP < 0.05 vs WS-Sham group;

^cP < 0.05 vs GK-Sham group;

^eP < 0.05 vs presurgery. GK: Goto-Kakizaki; RYGB: Roux-en-Y gastric bypass; WS: Wistar.

Table 4 Serum glucagon-like peptide-1 in different groups before and after surgery (x ± s, pmol/L)

Group	Presurgery	4 wk postsurgery
GK-RYGB	21.01 ± 0.90^a	34.36 ± 1.46^c^e
GK-Sham	21.19 ± 0.53^a	24.98 ± 2.63^a
WS-Sham	29.31 ± 1.51	32.13 ± 1.52

^aP < 0.05 vs WS-Sham group;

^cP < 0.05 vs GK-Sham group;

^eP < 0.05 vs presurgery. GK: Goto-Kakizaki; RYGB: Roux-en-Y gastric bypass; WS: Wistar.

Table 5 Amount of Akkermansia muciniphila in different groups before and after surgery (log10 copies/g)

Group	Presurgery	4 wk postsurgery
GK-RYGB	7.85 ± 0.09^a	9.34 ± 0.18^a^c^e
GK-Sham	7.79 ± 0.08^a	7.82 ± 0.09^a
WS-Sham	8.51 ± 0.08	8.82 ± 0.06

^aP < 0.05 vs WS-Sham group;

^cP < 0.05 vs GK-Sham group;

^eP < 0.05 vs presurgery. GK: Goto-Kakizaki; RYGB: Roux-en-Y gastric bypass; WS: Wistar.

Citation: Yan M, Song MM, Bai RX, Cheng S, Yan WM. Effect of Roux-en-Y gastric bypass surgery on intestinal Akkermansia muciniphila. World J Gastrointest Surg 2016; 8(4): 301-307
URL: https://www.wjgnet.com/1948-9366/full/v8/i4/301.htm
DOI: https://dx.doi.org/10.4240/wjgs.v8.i4.301