Retrospective Cohort Study
Copyright ©The Author(s) 2016.
World J Gastrointest Surg. Feb 27, 2016; 8(2): 161-168
Published online Feb 27, 2016. doi: 10.4240/wjgs.v8.i2.161
Table 1 Clinicopathological distribution according to the use of autologous intraoperative blood salvage for patients with hepatocellular carcinoma who underwent liver transplantation
Total (%) n = 158Intraoperative blood salvage
P
Yes (%) n = 122 (77.2)No (%) n = 36 (22.8)
Age158 (51-62)58 (51-62)58 (51-62)0.958
Male gender122 (77.2)95 (77.9)27 (75)0.821
BMI1225.7 (23.6-27.8)25.7 (23.6-27.8)25.5 (23.5-2.3)0.712
Pre-op AFP39.2 (3.7-35.4)8.9 (3.5-3.6)10.9 (6.7-33.7)0.175
Cirrhosis4135 (88.3)100 (84.8)35 (100)0.014
Alcohol422 (14.4)18 (15.3)4 (11.4)0.785
Hepatitis4
B20 (13.1)12 (10.2)8 (22.9)0.082
C97 (63.4)73 (61.9)24 (68.6)0.551
Others48 (5.2)8 (6.8)00.199
Blood type0.420
A60 (37)42 (34.4)18 (50)
B21 (13.3)17 (13.9)4 (11.1)
AB14 (8.9)11 (9)3 (8.3)
O63 (39.9)52 (42.6)11 (30.6)
Rhesus5123 (86.6)93 (86.1)30 (88.3)1.000
MELD110 ( 8-15)10.5 (9-17)9 (8-13.5)0.058
Radiofrequency44 (2.6)3 (2.6)1 (2.8)1.000
Chemoembolization469 (45.1)53 (45.3)16 (44.5)1.000
Alcoholization47 (4.6)5 (4.3)2 (5.6)0.668
Graft/body proportion121.75 (1.5-2.2)1.8 (1.5-2.2)1.7 (1.4– 2.2)0.454
Number of lesions12 (1-3)2 (1-3)2 (1-3)0.715
Largest lesion, mm125 (19-31)25 (19-30)25 (18-35)0.384
Edmond-steiner degree (III and IV)688 (59.9)67 (58.8)21 (63.5)0.689
Vascular invasion53 (33.6)44 (36.1)9 (25)0.236
Microsatellite lesions26 (16.5)19 (15.6)7 (19.4)0.612
Cholangiocarcinoma6 (3.8)6 (4.9)00.338
Recurrence14 (8.9)10 (8.2)4 (11.1)0.525
Death52 (32.9)41 (33.6)11 (30.6)0.841
Table 2 Univariate and multivariate analyses for predictors of overall survival
Total5-yr survival (%)Median survival (mo)Univariate analysis PHR95%CIMultivariate analysis P
Overall15859.7--
Age (≥ 60 yr)---0.133
Gender--0.097
Male12261.50.880.45-1.740.714
Female3655.4-
BMI (≥ 28)0.080
Yes3748.2461.550.81-2.980.186
No11363.6-
Pre-op AFP (≥ 100 ng/dL)0.087
Yes1951.8-1.500.68-3.320.316
No12960.8-
Cirrhosis---0.950
Alcohol related0.048
Yes2286.4-0.300.09-10.051
No13155.5-
Hepatitis B infection---0.156
Hepatitis C infection---0.130
Others---0.281
Blood type---0.470
Rhesus---0.554
Radiofrequency---0.821
MELD (≥ 15)---0.721
Chemo-embolization---0.877
Tumor alcoholization---0.118
Graft/body % (≥ 2)---0.163
No. of lesions (> 3)---0.819
Largest lesion (≥ 30 mm)---0.640
Edmond-Steiner degree0.013
III-IV8848.9512.191.07-4.470.031
0-II5974.4-
Vascular invasion---0.290
Microsatellite lesions---0.283
Cholangiocarcinoma---0.957
IBS0.510
Yes12259.5-1.560.74-3.300.237
No3664.5-
Table 3 Univariate analysis for predictors of recurrence
Total5-yr survival (%)Median survival (mo)Univariate analysis P
Overall15883.3--
Age (≥ 60 yr)---0.319
Male gender---0.410
BMI (≥ 28)---0.166
Pre-op AFP (≥ 100 mg/dL)0.001
Yes1959.484.5
No12985-
Cirrhosis---0.163
Alcohol related---0.207
Hepatitis B infection---0.911
Hepatitis C infection---0.568
Others---0.794
Blood type---0.912
Rhesus---0.494
MELD (≥ 15)---0.694
Radiofrequency---0.758
Chemoembolization---0.133
Tumor alcoholization---0.373
Graft/body % (≥ 2)---0.605
Number of lesions (> 3)---0.496
Largest lesion mm (≥ 30)---0.429
Edmond-Steiner degree0.0162
III-IV887384.5
0-II5994.3-
Vascular invasion0.071
Yes2674.884.5
No13286.3-
Microsatellite lesions0.007
Yes26--
No13286.5-
Cholangiocarcinoma---0.375
IBS0.953
Yes1228584.5
No3678.8-