Current status and recent advances of liver transplantation from donation after cardiac death

Table 1 Summary data on normothermic ex-vivo perfusion studies of donors after cardiac death liver

Author	Yr	Model	Summary	Outcome
Gong et al[54]	2008	Animal (swine)	Normothermic perfusion with autologous blood (n = 4), compared with cold stored controls in HTK solution (n = 4)	Improved bile production, less hepatocyte damage and favourable haemodynamic parameters
Manekeller et al[60]	2007	Animal (rat)	Oxygenated hypothermic machine perfusion at the end of cold storage (post perfusion)	Improved performance indicators comparable to controls
Reddy et al[37]	2005	Animal (swine)	Normothermic perfusion for 24 h (n = 5%) compared with sequential cold storage of 1 h followed by 20 h normothermic perfusion (n = 5)	Greater hepatocyte injury whilst retaining the synthetic function
Reddy et al[53]	2004	Animal (swine)	Normothermic perfusion for 24 h (n = 4) compared with sequential 4 h cold storage followed by 20 h normothermic reperfusion (post-conditioning, n = 4)	Greater hepatocyte injury in the sequential post conditioning group
St Peter et al[55]	2002	Animal (swine)	Hypothermic storage (n = 4) compared to normothermic perfusion ex-vivo (n = 4) - reperfusion model not transplant	Recovery of synthetic function, less hepatocyte injury and improved substrate utilisation
Imber et al[51]	2002	Animal (swine)	Normothermic perfusion (n = 5) compared with standard cold storage (n = 5)	Improved bile production, glucose metabolism and less hepatocyte injury

HTK: Histidine-tryptophan-ketoglutarate.