Impact of metastatic lymph node ratio in node-positive colorectal cancer

Table 1 Lymph node ratio (LNR) in colorectal cancer

Author, year	[Reference]	No. of patients	Selection of patients	Cut-off of LNR	5-year overall survival (%)	Uni P value	Multi P value	HR (95% CI)
Berger et al, 2005	[22]	3411	Stage II and III	< 0.05	79	< 0.0001	1NSa	-
			colon cancer	0.05-0.19	73		1< 0.0001b	13.87 (NA)b
				0.2-0.39	63		1< 0.0001c	112.43 (NA)c
				0.4-1.0	52
De Ridder et al, 2006	[48]	26181	Node-positive	-0.4	56	-	< 0.0001	-
			colon cancer	0.4-	25
Schumacher et al, 2007	[50]	232	Non-stage IV	< 0.08	-	< 0.05	-	-
			colon cancer	0.08 ≤	-
Lee et al, 2007	[51]	201	Stage III colon cancer	0.01-0.11	83.6d	< 0.0001	< 0.0001	1
				0.12-0.24	61.1d			2.973 (1.407-6.280)
				0.25-0.92	20d			8.362 (3.739-18.704)
Wang et al, 2008, 2009	[27,54]	24477	Stage III colon cancer	< 1/14	64.8	< 0.0001	1< 0.0001	12.30 (2.083-2.545)
				1/14 ≤ - < 0.25	56.2
				0.25 ≤ - 0.50	45.1
				0.50 ≤ - ≤ 1.0	29.6
Rosenberg et al, 2008	[26]	3026	Colorectal cancer	0	87.1	< 0.001	< 0.001	1 (NA)
				0.01-0.17	60.6			1.92 (NA)
				0.18-0.41	34.4			2.92 (NA)
				0.42-0.69	17.6			3.62 (NA)
				0.70 ≤	5.3			4.31 (NA)
Peng et al, 2008	[52]	318	Node-positive	< 0.14	72.19	0.002	10.003	13.11 (1.47-6.58)
			rectal cancer	0.14-0.49	61.92
				0.5-1	38.47
Peschaud et al, 2008	[53]	307	Rectal cancer	0	89e	0.0013	10.0003	11.019 (1.009-1.029)
				0.01-0.07	92e
				0.07-0.2	71e
				0.2 <	67e
Derwinger et al, 2008	[55]	136	Stage IV	0-0.15	708 df	< 0.0049	1< 0.05g	2.1 (1.3-3.6)g
			colorectal cancer	0.16-0.65	438 df
				0.66-1	277 df
Derwinger et al, 2008	[56]	265	Stage III colon cancer	0-0.125	80h	< 0.001	1< 0.0002	110.6 (3.2-31.8)
				0.126-0.266	-
				0.267-0.450	-
				0.451-1	29h
Vather et al, 2009	[57]	2364	Stage III colon cancer	Lowest group	55-60	< 0.0001	-	-
				Higher group	10-20
Chin et al, 2009	[34]	490	Stage III colon cancer	≤ 0.4	66.7d	< 0.0001		1
			(LN ≥ 12)	0.4 < ≤ 0.7	35.1d		0.001	2.298 (1.384-3.815)
				0.7 <	0d		< 0.001	7.407 (3.153-17.397)
Vaccaro et al, 2009	[61]	362	Stage III colon cancer	< 0.25	64.9	< 0.0001	0.005	1
				0.25 ≤	38.3			2.3 (1.3-4.1)
Park et al, 2009	[28]	318	Stage III colon cancer	< 0.059	83.6h	0.0002	-	-
				0.059-0.23	71.1h
				0.23 <	55h
Priolli et al, 2009	[58]	113	Colorectal cancer	0	More than 80	0.03	10.003	18.575 (NA)
				0.01-0.2	67.6
				0.21 ≤	37.5
Moug et al, 2009	[59]	295	Colorectal cancer	< 0.05	-	< 0.001	1< 0.001i	111.65 (5.00-27.15)i
				0.05-0.19	-		1< 0.001j	113.40 (3.64-49.10)j
				0.20-0.39	-
				0.40-1.00	-
Kim et al, 2009	[60]	232	Stage III rectal cancer	≤ 0.1	89	< 0.001		1
				0.1 < - ≤ 0.2	67		0.623	1.260 (0.501-3.173)
				0.2 < - ≤ 0.4	64		0.0047	2.435 (1.012-5.862)
				0. 4 <	50		0.005	3.701 (1.493-9.178)

Uni: Univariate analysis; Multi: Multivariate analysis; HR: Hazard ratio; 95% CI: 95% Confidence interval; NS: Not significant; NA: Not available; LN, Lymph node;

¹In multivariate analysis, LNR was considered as a continuous variable;

^aIn patients with LN < 10;

^bIn patients with LN 10-15;

^cIn patients with LN > 15;

^d5-year disease-free survival;

^e3-year overall survival;

^fMedian survival in days;

^gIn patients with LN ≥ 12;

^h3-year disease-free survival;

ⁱIn colon cancer patients;

^jIn rectal cancer patients.