Differences between main-duct and branch-duct intraductal papillary mucinous neoplasms of the pancreas

Table 1 Epidemiological and clinicopathological characteristics of patients with main-duct, branch-duct and combined intraductal papillary mucinous neoplasms n,%

	Main duct IPMNs (n = 81)	Branch duct IPMNs (n = 159)	P value, MD vs BD
Median age, yr (range)	67 (37-85)	66 (35-90)	n.s.
Sex
Female	36 (44.5)	91 (57)	0.04
Male	45 (55.5)	68 (43)
Positive family history of pancreatic cancer	6 (7.5)	16 (11)	n.s.
Positive History of other neoplasm	18 (22)	32 (20)	n.s.
Tumor site
Proximal	52 (64)	82 (52)	n.s.
Distal	26 (32)	40 (25)	n.s.
Diffuse	3 (4)	37 (23)	0.0001
Entire pancreas along MPD	3 (4)	0
Multifocal lesions	0	37 (23)
Incidental diagnosis	11 (13.5)	55 (34.5)	0.0001
Abdominal pain
Yes	45 (53)	72 (45)	n.s.
No	38(47)	87 (55)
Presence of other symptomsa
Yes	59 (73)	72 (45)	0.0001
No	22 (27)	87 (65)
Jaundice	14 (17)	7 (5)	0.001
Diabetes	10 (12)	14 (9)	n.s.
Weight loss	41 (50.5)	37 (23)	0.0001
Acute pancreatitis	14 (17)	27 (17)	n.s.
Pathology
Adenoma	9 (11)	71 (44)	0.0001
Borderline	17 (21)	54 (34)	0.05
Carcinoma in situ	16 (20)	17 (11)	n.s.
Invasive carcinoma	39 (48)	17 (11)	0.0001
Presence of lymph node metastasesb	13 (33)	4 (23.5)	n.s.

^aSome patients complained of more than 1 symptom; ^bRate of lymph node metastases was calculated considering only patients with invasive intraductal papillary mucinous carcinomas. IPMNs: Intraductal papillary mucinous neoplasms; MD: Main-duct; BD: Branch-duct.