Morphomics in esophageal cancer: Validation and association with muscular and cardiorespiratory fitness

Table 1 Body composition correlation between T10-12 morphomics and bioelectrical impedance analysis

Bioelectrical impedance analysis	Morphomics	Spine level	Correlation	P value
Body cell mass	DMG volume	T10	0.594	< 0.001
		T11	0.647	< 0.001
		T12	0.684	< 0.001
	DMG area	T10	0.647	< 0.001
		T11	0.543	< 0.001
		T12	0.664	< 0.001
Body fat percentage	SF area	T10	0.666	< 0.001
		T11	0.672	< 0.001
		T12	0.674	< 0.001
	VF area	T10	0.576	< 0.001
		T11	0.578	< 0.001
		T12	0.606	< 0.001
	DMG density	T10	-0.469	< 0.001
		T11	-0.457	< 0.001
		T12	-0.513	< 0.001
Fat free mass	SF area	T10	0.597	< 0.001
		T11	0.599	< 0.001
		T12	0.590	< 0.001
	SF area	T10	-0.244	0.09
		T11	-0.281	0.048
		T12	-0.420	0.002
	VF area	T10	0.491	< 0.001
		T11	0.568	< 0.001
		T12	0.491	< 0.001
	DMG volume	T10	0.589	< 0.001
		T11	0.642	< 0.001
		T12	0.589	< 0.001
	DMG area	T10	0.643	< 0.001
		T11	0.528	< 0.001
		T12	0.643	< 0.001
Lean body mass	DMG volume	T10	0.556	< 0.001
		T11	0.584	< 0.001
		T12	0.556	< 0.001
	DMG area	T10	0.613	< 0.001
		T11	0.459	< 0.001
		T12	0.613	< 0.001
Skeletal muscle mass	DMG volume	T10	0.598	< 0.001
		T11	0.650	< 0.001
		T12	0.598	< 0.001
	DMG area	T10	0.650	< 0.001
		T11	0.546	< 0.001
		T12	0.650	< 0.001
Appendicular skeletal muscle	DMG volume	T10	0.603	< 0.001
		T11	0.670	< 0.001
		T12	0.671	< 0.001
	DMG area	T10	0.638	< 0.001
		T11	0.542	< 0.001
		T12	0.653	< 0.001
Muscle mass, left arm	DMG volume	T10	0.540	< 0.001
		T11	0.679	< 0.001
		T12	0.540	< 0.001
	DMG area	T10	0.628	< 0.001
		T11	0.605	< 0.001
		T12	0.628	< 0.001
Muscle mass, left leg	DMG volume	T10	0.594	< 0.001
		T11	0.629	< 0.001
		T12	0.594	< 0.001
	DMG area	T10	0.601	< 0.001
		T11	0.494	< 0.001
		T12	0.601	< 0.001
Muscle mass, right arm	DMG volume	T10	0.540	< 0.001
		T11	0.677	< 0.001
		T12	0.540	< 0.001
	DMG area	T10	0.623	< 0.001
		T11	0.571	< 0.001
		T12	0.623	< 0.001
Muscle mass, right leg	DMG volume	T10	0.605	< 0.001
		T11	0.637	< 0.001
		T12	0.605	< 0.001
	DMG area	T10	0.621	< 0.001
		T11	0.497	< 0.001
		T12	0.621	< 0.001
Muscle mass, trunk	DMG volume	T10	0.568	< 0.001
		T11	0.705	< 0.001
		T12	0.568	< 0.001
	DMG area	T10	0.646	< 0.001
		T11	0.598	< 0.001
		T12	0.646	< 0.001

DMG: Dorsal muscle group; SF: Subcutaneous fat; VF: Visceral fat.

Table 2 Correlation between T10-12 morphomics and muscular and cardiorespiratory fitness

Musclar/cardiorespiratory fitness	Morphomics	Spine level	Correlation	P value
Hand grip strength	DMG volume	T10	0.482	< 0.001
		T11	0.396	0.004
		T12	0.455	< 0.001
	DMG area	T10	0.514	< 0.001
		T11	0.358	0.01
		T12	0.350	0.01
Peak VO2	DMG volume	T10	0.504	< 0.001
		T11	0.483	< 0.001
		T12	0.466	< 0.001
	DMG area	T10	0.460	< 0.001
		T11	0.435	0.002
		T12	0.424	0.002
Peak WR	DMG volume	T10	0.435	0.002
		T11	0.430	0.002
		T12	0.436	0.002
	DMG area	T10	0.380	0.006
		T11	0.394	0.005
		T12	0.338	0.016
Peak VO2/BW	SF area	T10	-0.469	< 0.001
		T11	-0.457	< 0.001
		T12	-0.461	< 0.001
	VF area	T10	-0.290	0.041
		T11	-0.400	0.004
		T12	-0.436	0.002
	DMG density	T10	0.385	0.006
		T11	0.319	0.024
		T12	0.408	0.003
%predicted peak VO2	SF area	T10	-0.486	< 0.001
		T11	-0.478	< 0.001
		T12	-0.471	< 0.001
	VF area	T10	-0.335	0.017
		T11	-0.455	< 0.001
		T12	-0.464	< 0.001
	DMG density	T10	0.341	0.015
		T11	0.373	0.008
		T12	0.462	< 0.001
VAT	DMG area	T10	0.356	0.011
		T11	0.324	0.022
		T12	0.327	< 0.001
VAT WR	BMD	T10	0.341	< 0.001
		T11	0.328	< 0.001
		T12	0.330	< 0.001
VAT/BW	BMD	T10	0.374	0.007
		T11	0.361	0.01
		T12	0.314	0.026
	SF area	T10	-0.373	0.008
		T11	-0.383	0.006
		T12	-0.373	0.008
	VF area	T10	-0.430	0.002
		T11	-0.522	< 0.001
		T12	-0.520	< 0.001
EqO2nadir	SF area	T10	-0.350	0.013
		T11	-0.341	0.016
		T12	-0.334	0.018
Oxygen uptake efficiency slope	DMG volume	T10	0.449	0.001
		T11	0.483	< 0.001
		T12	0.509	< 0.001
	DMG area	T10	0.449	0.001
		T11	0.435	0.002
		T12	0.451	0.001

BMD: Bone mineral density; BW: Body weight; EqO₂: Ventilatory equivalent for O₂; VO₂: Oxygen consumption; VAT: Ventilatory anaerobic threshold; WR: Work rate; DMG: Dorsal muscle group; SF: Subcutaneous fat; VF: Visceral fat.

Table 3 Full logistic regression model and parsimonious model after stepwise variable selection for ventilatory anaerobic threshold normalized by body weight ≤ 11 mL/kg/min with morphomics

Predictor	Full model		Parsimonious model
	OR (95%CI)	P value	OR (95%CI)	P value
Bone mineral density	0.37 (0.14-0.85)	0.03	0.42 (0.17-0.90)	0.038
Subcutaneous fat area	0.94 (0.25-4.55)	0.93
Subcutaneous fat density	0.93 (0.26-2.97)	0.90
Visceral fat area	5.73 (1.39-33.37)	0.03	5.01 (1.91-18.72)	0.0046
Visceral fat density	1.17 (0.45-3.09)	0.75
Dorsal muscle group volume	0.27 (0.05-1.12)	0.10	0.41 (0.15-0.94)	0.051
Dorsal muscle group area	1.59 (0.38-7.52)	0.54
Dorsal muscle group density	1.22 (0.48-3.16)	0.67

OR: Odds ratio; CI: Confidence interval.