Pathological features and risk factors for submucosal infiltration of colorectal lateral spreading tumors

Table 1 Clinical and pathological characteristics of different endoscopic subtypes of lateral developing tumors at 456 locations

Project	LST-NG-F (n = 109)	LST-NG-PD (n = 58)	IST-G H (n = 27)	LST GM (n = 262)
Lesion size
1-2 cm	93	45	15	117
> 2-3 cm	13	8	5	70
> 3-4 cm	1	5	2	30
> 4-5 cm	2	0	2	26
> 5 cm	0	0	3	19
Location of lesion
Rectum	8	5	3	99
Sigmoid colon	10	8	0	22
Descending colon	10	7	1	8
Transverse colon	48	21	4	36
Ascending colon	28	13	9	62
Cecum	5	4	10	35
Pathologic diagnosis
LGIN	62	12	8	37
HGIEN	44	24	14	139
Mucosal layer cancer	2	12	4	64
Submucosal carcinoma	1	10		22

LST: Lateral developing tumors.

Table 2 Univariate logistic regression analysis of risk factors for malignant transformation of colorectal lateral developing tumors, n (%)

Project	Non cancerous group (n = 340)	Cancer group (n = 116)	χ2 value	P value
Gender			3.706	0.054
Male	173 (50.9)	71 (61.2)
Female	167 (49.1)	45 (38.8)
Age			1.820	0.177
≤ 64	180 (52.9)	53 (45.7)
> 64	160 (47.1)	63 (54.3)
Disease size			45.072	< 0.001
≤ 2 cm	232 (68.2)	38 (32.8)
> 2 cm	108 (31.8)	78 (67.2)
Location of lesion			51.821	< 0.001
Cecum	50 (14.7)	4 (3.4)
Ascending colon	89 (26.2)	23 (19.8)
Transverse colon	94 (27.6)	15 (12.9)
Descending colon	20 (5.9)	6 (5.2)
Sigmoid colon	28 (8.2)	12 (10.3)
Rectum	59 (17.4)	56 (48.3)
Endoscopic classification			42.566	< 0.001
LST-NG-F	106 (31.2)	3 (2.6)
LST-NG-PD	36 (10.6)	22 (19.0)
LST-G-H	22 (6.5)	5 (4.3)
LST-G-M	176 (51.8)	86 (74.1)
Accompanied by large nodules			91.969	< 0.001
No	316 (92.9)	63 (54.3)
Yes	24 (7.1)	53 (45.7)
Accompanied by other adenomas			0.003	0.959
No	77 (22.6)	26 (22.4)
Yes	263 (77.4)	116 (77.6)

LST: Lateral developing tumors.

Table 3 Multivariate logistic regression analysis of risk factors for malignant transformation of colorectal lateral developing tumors

Project	β value	Wald	OR (95%CI)	P value
Gender
Male			1
Female	-0.303	1.172	0.738 (0.426-1.279)	0.279
Lesion size
≤ 2 cm			1
> 2 cm	1.232	8.182	3.427 (1.474-7.968)	0.004
Location of lesion
Transverse colon			1
Cecum	-1.224	3.583	0.294 (0.083-1.044)	0.058
Ascending colon	0.573	1.866	1.773 (0.780-4.032)	0.172
Descending colon	0.380	0.369	1.463 (0.429-4.984)	0.543
Sigmoid colon	0.846	2.729	2.329 (0.854-6.352)	0.099
Rectum	0.930	4.849	2.534 (1.108-5.799)	0.028
Accompanied by large nodules
No			1
Yes	1.943	30.551	6.979 (3.504-13.900)	< 0.001
Endoscopic classification
LST-NG-F			1
LST-NG-PD	3.053	21.075	21.186 (5.864-76.544)	< 0.001
LST-G-H	2.204	7.555	9.064 (1.882-43.650)	0.006
LST-G-M	1.627	6.447	5.086 (1.449-17.852)	0.011

LST: Lateral developing tumors.

Table 4 Univariate logistic regression analysis of risk factors for submucosal infiltration in lateral developmental colorectal tumors, n (%)

Project	Non submucosal infiltration group (n = 422)	Submucosal infiltration group (n = 34)	χ2	P value
Gender,			2.952	0.086
Male	221 (52.4)	23 (67.6)
Female	201 (47.6)	11 (32.4)
Age			0.240	0.624
≤ 64	217 (51.4)	16 (47.1)
> 64	205 (48.6)	18 (52.9)
Disease size			3.465	0.063
≤ 2 cm	255 (60.4)	15 (44.1)
> 2 cm	167 (39.6)	19 (55.9)
Location of lesion			14.281	0.014
Cecum	54 (12.8)	0 (0.0)
Ascending colon	104 (24.6)	8 (23.5)
Transverse colon	104 (24.6)	5 (14.7)
Descending colon	24 (5.7)	2 (5.9)
Sigmoid colon	35 (8.3)	5 (14.7)
Rectum	101 (23.9)	14 (41.2)
Endoscopic classification			17.584	0.001
LST-NG-F	108 (25.6)	1 (2.9)
LST-NG-PD	48 (11.4)	10 (29.4)
LST-G-H	26 (6.2)	1 (2.9)
LST-G-M	240 (56.9)	22 (64.7)
Accompanied by large nodules			52.724	< 0.001
No	366 (86.7)	13 (38.2)
Yes	56 (13.3)	21 (61.8)
Accompanied by other polyps			0.513	0.474
No	97 (23.0)	6 (17.6)
Yes	325 (77.0)	28 (82.4)

LST: Lateral developing tumors.

Table 5 Multivariate logistic regression analysis of risk factors for submucosal infiltration in colorectal lateral developing tumors

Project	β value	Wald	OR value (95%CI)	P value
Location of lesion
Transverse colon			1
Cecum	-18.416	0.000	0	0.997
Ascending colon	0.799	1.462	2.224 (0.593-3.697)	0.227
Descending colon	0.213	0.051	1.237 (0.387-5.797)	0.821
Sigmoid colon	0.846	1.250	2.330 (0.662-6.322)	0.264
Rectum	-0.420	0.350	0.657 (0.163-2.642)	0.554
Accompanied by large nodules
No			1
Yes	4.643	18.197	103.873 (12.303-877.016)	< 0.001
Endoscopic classification
LST-NG-F			1
LST-NG-PD	3.146	8.640	23.234 (2.837-64.408)	0.003
LST-G-H	1.750	1.441	5.756 (1.304-49.870)	0.230
LST-G-M	-0.594	0.174	0.552 (0.034-8.991)	0.676

LST: Lateral developing tumors.