Diagnostic value of serum vascular endothelial growth factor and interleukin-17 in primary hepatocellular carcinoma

Table 1 Comparison of demographic characteristics between the control group and the study group

Data		Control group (n = 50)	Study group (n = 50)	t/χ2 value	P value
Gender, n (%)	Male	32 (64.0)	35 (70.0)	0.407	0.523
	Female	18 (36.0)	15 (30.0)
Age (year)		48.22 ± 4.23	47.48 ± 3.73	0.940	0.349
Height (m)		1.68 ± 0.16	1.67 ± 0.15	0.322	0.748
Education level, n (%)	Elementary school and below	2 (4.0)	4 (8.0)	1.940	0.585
	Junior high school	11 (22.0)	10 (20.0)
	High School	20 (40.0)	24 (48.0)
	College and above	17 (34.0)	12 (24.0)
Marital status, n (%)	Unmarried	3 (6.0)	6 (12.0)	1.673	0.643
	Married	38 (76.0)	36 (72.0)
	Divorced	8 (16.0)	6 (12.0)
	Widowed	1 (2.0)	2 (4.0)
Place of residence, n (%)	City	28 (56.0)	31 (62.0)	0.372	0.542
	Village or town	22 (44.0)	19 (38.0)

Table 2 Comparison of serum vascular endothelial growth factor and interleukin-17 levels in different pathological characteristics of the study groups

Factor	Classification	Cases	VEGF (pg/mL)	P value	IL-17 (pg/mL)	P value
Gender	Male	35	264.90 ± 113.04	0.800	36.15 ± 13.26	0.228
	Female	15	274.17 ± 128.28		37.06 ± 12.07
Age	< 50 years old	36	275.39 ± 107.69	0.467	35.83 ± 11.95	0.606
	≥ 50 years old	14	248.37 ± 139.08		37.94 ± 15.15
Histological classification	Hepatocellular type	41	268.75 ± 109.59	0.892	37.00 ± 13.15	0.504
	Cholangiocyte type	9	262.83 ± 152.11		33.81 ± 11.35
TNM stage	Stage I + Stage II	19	217.72 ± 97.70	0.016	28.44 ± 11.25	< 0.001
	Stage III + Stage IV	31	298.30 ± 117.96		41.32 ± 11.25
Tumor diameter	> 5 cm	21	255.59 ± 112.66	0.538	38.93 ± 12.72	0.243
	≤ 5 cm	29	276.44 ± 120.51		34.61 ± 12.76
Combined cirrhosis	Yes	28	249.73 ± 114.81	0.223	34.64 ± 12.43	0.271
	No	22	290.53 ± 117.38		38.69 ± 13.18
Degree of differentiation	Highly differentiated	27	277.33 ± 111.53	0.532	37.78 ± 13.15	0.418
	Low differentiation	23	256.35 ± 123.74		34.82 ± 12.47
Tumor metastasis	Yes	24	304.50 ± 117.44	0.030	43.79 ± 10.90	< 0.001
	No	26	233.69 ± 106.95		29.91 ± 10.94

VEGF: Vascular endothelial growth factor; IL: Interleukin.

Table 3 Diagnostic value of serum vascular endothelial growth factor and interleukin-17 levels for primary hepatocellular carcinoma

Indicator	AUC	95%CI	Optimal cut-off value	Sensitivity (%)	Specificity (%)
VEGF	0.919	0.861-0.977	102.775	82.00	94.40
IL-17	0.898	0.799-0.997	13.289	92.60	86.50

AUC: Area under the curve; VEGF: Vascular endothelial growth factor; IL: Interleukin.