Impact of minimally invasive surgery on immune function and stress response in gastric cancer patients

Table 1 Comparison of surgical parameters between two groups, mean ± SD

Group	Number of cases	Surgical incision (cm)	Intraoperative blood loss (mL)	Surgical duration (min)	Number of lymph nodes dissected
Minimally invasive surgery group	102	5.06 ± 2.11	133.87 ± 22.96	175.42 ± 23.15	15.27 ± 1.36
Open surgery group	101	7.59 ± 2.53	215.48 ± 30.61	232.59 ± 28.06	13.87 ± 1.28
t value		5.743	13.785	9.263	5.107
P value		< 0.001	< 0.001	< 0.001	< 0.001

Table 2 Comparison of recovery between two groups, mean ± SD

Group	Number of cases	Time to anal exhaust (d)	Time to start eating (d)	Time to get out of bed (d)	Length of hospital stay (d)
Minimally invasive surgery group	102	2.31 ± 1.05	5.47 ± 1.02	2.31 ± 0.75		11.12 ± 1.29
Open surgery group	101	4.63 ± 1.77	6.12 ± 1.83	3.48 ± 0.54		15.43 ± 1.87
t value		7.241	4.112	7.269		10.881
P value		< 0.001	< 0.001	< 0.001		< 0.001

Table 3 Comparison of immune function between two groups, mean ± SD

Indicator	Minimally invasive surgery group	Open surgery group	t value	P value
IgA (ng/L)
Preoperative	4.25 ± 1.15	4.31 ± 1.33	0.615	> 0.05
Postoperative 3 d	3.87 ± 0.72a	3.13 ± 0.51a	5.897	< 0.05
IgG (ng/L)
Preoperative	20.97 ± 2.64	21.04 ± 2.57	0.338	> 0.05
Postoperative 3 d	17.81 ± 2.54a	13.45 ± 2.67a	6.208	< 0.05
IgM (ng/L)
Preoperative	3.31 ± 0.56	3.27 ± 0.79	0.736	> 0.05
Postoperative 3 d	2.76 ± 0.36a	2.18 ± 0.51a	6.083	< 0.05

^aP < 0.05 vs the same group.

Table 4 Comparison of intestinal barrier function between two groups, mean ± SD

Indicator	Minimally invasive surgery group	Open surgery group	t value	P value
D-lactic acid (mg/L)
Preoperative	5.91 ± 0.53	5.93 ± 0.56	0.626	> 0.05
Postoperative 3 d	2.56 ± 0.65a	3.45 ± 0.73a	7.531	< 0.05
DAO (U/L)
Preoperative	4.71 ± 0.68	4.68 ± 0.59	0.442	> 0.05
Postoperative 3 d	1.78 ± 0.88a	2.64 ± 0.79a	6.873	< 0.05

^aP < 0.05 vs the same group.

DAO: Diamine oxidase.

Table 5 Comparison of stress response between two groups, mean ± SD

Indicator	Minimally invasive surgery group	Open surgery group	t value	P value
CRP (mg/L)
Preoperative	5.67 ± 0.97	5.71 ± 0.89	0.818	> 0.05
Postoperative 3 d	52.34 ± 1.65a	63.47 ± 1.77a	47.231	< 0.05
IL-6 (pg/mL)
Preoperative	5.73 ± 0.62	5.69 ± 0.58	0.742	> 0.05
Postoperative 3 d	317.78 ± 5.83a	363.14 ± 6.79a	76.897	< 0.05
PCT (ug/L)
Preoperative	0.71 ± 0.87	0.92 ± 1.08	0.546	> 0.05
Postoperative 3 d	52.34 ± 1.65a	3.57 ± 0.38a	16.194	< 0.05

^aP < 0.05 vs the same group.

CRP: C-reactive protein; IL: Interleukin; PCT: Procalcitonin.