Comparison efficacy and safety of total laparoscopic gastrectomy and laparoscopically assisted total gastrectomy in treatment of gastric cancer

Table 1 Basic information of included literature

Ref.	Countries	Sample size		Age (yr, mean ± SD)		Body mass index (kg/m²), mean ± SD)		NOS score
		TLTG group	LATG group	TLTG group	LATG group	TLTG group	LATG group
Kim et al[4], 2013	South Korea	90	23	58.0 ± 10.8	56.8 ± 14.2	23.2 ± 2.9	22.2 ± 1.8	7
Kim et al[5], 2016	South Korea	27	29	60.8 ± 9.1	59.3 ± 13.1	24.0 ± 2.9	23.3 ± 3.2	7
Chen et al[6]	China	108	145	59.4 ± 11.1	57.3 ± 12.5	23.5 ± 3.5	23.1 ± 4.2	8
Gong et al[7], 2017	South Korea	421	266	57.78 ± 11.2	55.69 ± 11.96	/	/	7
Huang et al[8], 2017	China	51	456	55.5 ± 12.1	61.6 ± 11.2	22.5 ± 13.1	22.3 ± 13.5	7
Lu et al[9], 2016	China	25	25	59+8.9	58.4 ± 7.7	22.5 ± 2.5	22.9 ± 3.7	8
Cui et al[10]	China	16	47	61.3 ± 13.	67.6+13	22.8 ± 1.2	23.2+1.3	8
Hong et al[11], 2017	China	183	190	58 ± 11	60 ± 10	23 ± 3	22 ± 3	8
Hua et al[12], 2017	China	47	47	48.51 ± 2.47	48.67 ± 2.51		/	7
Xiao et al[13], 2015	China	30	32	/	/		/	6
Ito et al[14], 2014	Japan	117	46			/	/	6

TLTG: Totally laparoscopic total gastrectomy; LATG: Laparoscopic-assisted total gastrectomy; NOS: Newcastle-Ottawa Scale.

Table 2 Intraoperative and postoperative clinical data and analysis results included in the literature

Observation indicators	References	Sample size (examples)		Heterogeneity	Effect model	Comprehensive effect value	95%CI	P value
		TLTG group	LATG group
Operative time	9	664	1008	< 0.001, 83%	R	WMD = 7.62	-4.35-19.59	0.21
Match time	3	165	206	< 0.001, 86%	R	WMD = 6.40	-2.28-15.08	0.15
Tumor size	7	905	1134	0.02, 61%	R	WMD = -0.29	-0.65-0.17	0.12
Proximal edge distance	5	597	512	< 0.001, 84%	R	WMD = -0.22	-0.86-0.41	0.49
Intraoperative bleeding volume	9	604	1017	< 0.001, 84%	R	WMD = -26.29	-43.70 to -8.88	0.003
Number of lymph node removals	9	973	1235	0.02, 57%	R	WMD = 1.78	0.06-3.50	0.04
Postoperative pain score
On the first day after surgery (8:00 am)	2	511	289	0.91, 0%	R	WMD = 0.03	-0.20-0.27	0.78
On the 3rd day after surgery (8:00 am)	2	511	289	0.46, 0%	R	WMD = 0.08	-0.13-0.28	0.45
Postoperative peak pain	2	511	289	0.09, 66%	R	WMD = 0.17	-0.71-1.05	0.70
Postoperative anal exhaust time	8	547	962	< 0.001, 89%	R	WMD = -0.22	-0.56-0.13	0.22
Postoperative feeding time	8	547	962	< 0.001, 86%	R	WMD = -0.56	-1.07 to -0.06	0.03
Postoperative hospitalization time	9	577	994	< 0.001, 93%	R	WMD = -1.53	-2.83 to -0.23	0.02
The incidence of anastomotic complications	11	1115	1306	0.74, 0%	R	OR = 0.71	0.47-1.06	0.09
Anastomotic fistula	11	1115	1306	0.53, 0%	R	OR = 0.70	0.42-1.18	0.18
Anastomotic stenosis	11	1115	1306	0.85, 0%	R	OR = 0.84	0.41-1.71	0.63
Anastomotic bleeding	8	439	817	0.93, 0%	R	OR = 0.86	0.34-2.15	0.74
Overall incidence of complications	9	947	804	0.81, 0%	R	OR = 0.93	0.71-1.21	0.58

TLTG: Totally laparoscopic total gastrectomy; LATG: Laparoscopic-assisted total gastrectomy; WMD: Weighted mean difference.