Global geoepidemiology of gastrointestinal surgery rates in Crohn’s disease

Table 1 Baseline characteristics of the included studies

Ref.	Region	Total (N)	Surgeries (n)
Chow et al[22], 2009	Asia	132	57
Jeon et al[29], 2010	Asia	96	15
Lee et al[32], 2017	Asia	165	28
Pandey et al[34], 2015	Asia	430	112
Varma et al[38], 20191	Asia	103	16
Kariyawasam et al[30], 2014	Australia	1035	388
Alvarez-Lobos et al[17], 2005	Europe	170	59
Bernell et al[19], 2000	Europe	1936	1424
Chhaya et al[20], 2015	Europe	5235	32
Chhaya et al[21], 2016	Europe	9391	1714
Cosnes et al[23], 2005	Europe	2573	1070
Golovics et al[28], 2013	Europe	506	204
González-Lama et al[44], 2016	Europe	467	210
Szántó et al[37], 2018	Europe	428	228
Zaharie et al[39], 2016	Europe	478	78
Cushing et al[24], 2018	North America	400	198
Dubinsky et al[25], 2013	North America	1115	444
Feagan et al[26], 2008	North America	778	13
Forcione et al[27], 2004	North America	345	69
Kuenzig et al[31], 2018	North America	2113	532
Nguyen et al[33], 2017	North America	8985	2648
Peyrin-Biroulet et al[35], 2012	North America	310	152
Reutemann et al[36], 2017	North America	135	84
Varma et al[38], 20191	North America	99	16

¹Data from same study.

Table 2 Continent based variation in Crohn’s disease surgery rates

Region	n (median, range)	GI surgery (median, range)	Proportion surgery (median, range)
North America	400 (99-8985)	152 (13-2648)	29.0% (1.6%-62.0%)
Europe	506 (170-9391)	210 (32-1714)	40.0% (0.6%-74.0%)
Asia	132 (96-430)	28 (15-112)	17.0% (16.0%-43.0%)
Oceania	1035	388	38.0%

Table 3 Summary of included studies based on population basis, time period, follow up period, and journal publication

Ref.	Population based	Time period	Follow up period	Journal publication
Chow et al[22], 2009	No	1987-2007	5.0 yr	Inflammatory Bowel Diseases Journal
Jeon et al[29], 2010	No	-	36.0 months	Korean Journal of Gastroenterology
Lee et al[32], 2017	No	2000-2015	6.0 months	World Journal of Gastroenterology
Pandey et al[34], 2015	Yes	1970-2013	7.3 years	Inflammatory Bowel Diseases Journal
Varma et al[38], 20191	Yes	2014-2018	-	Journal of Gastroenterology & Hepatology Foundation
Kariyawasam et al[30], 2014	No	1970-2009	12.0 months	Inflammatory Bowel Diseases Journal
Alvarez-Lobos et al[17], 2005	No	2002-2004	7.4 yr	Annals of Surgery
Bernell et al[19], 2000	Yes	1955-1989	14.9 yr	Annals of Surgery
Chhaya et al[20], 2015	Yes	1995-2009	4.8 yr	Inflammatory Bowel Diseases Journal
Chhaya et al[21], 2016	Yes	1989-2009	5.8 yr	European Journal of Gastroenterology & Hepatology
Cosnes et al[23], 2005	No	1978-2002	5.0 yr	Gut Journal
Golovics et al[28], 2013	Yes	1977-2008	1.0 yr	World Journal of Gastroenterology
González-Lama et al[44], 2016	No	-	10.7 yr	Inflammatory Bowel Diseases Journal
Szántó et al[37], 2018	No	2007-2015	3.6 yr	PLOS One Journal
Zaharie et al[39], 2016	Yes	2006-2014	-	Journal of Crohn's and Colitis
Cushing et al[24], 2018	No	2014-2016	-	Inflammatory Bowel Diseases Journal
Dubinsky et al[25], 2013	No	-	60.0 months	Inflammatory Bowel Diseases Journal
Feagan et al[26], 2008	No	-	12.0 months	Gastroenterology Journal
Forcione et al[27], 2004	No	1991-1999	3.0 yr	Gut Journal
Kuenzig et al[31], 2018	Yes	1994-2010	2.0 yr	American Journal of Gastroenterology
Nguyen et al[33], 2017	Yes	1999-2008	-	Inflammatory Bowel Diseases Journal
Peyrin-Biroulet et al[35], 2012	Yes	2000-2009	12.0 yr	American Journal of Gastroenterology
Reutemann et al[36], 2017	No	2006-2014	41.7 months	Inflammatory Bowel Diseases Journal
Varma et al[38], 20191	No	2014-2018	12.0 months	Journal of Gastroenterology & Hepatology Foundation

¹Data from same study.