Correlation between postoperative chemotherapy regimen and survival in patients with resectable gastric adenocarcinoma accompanied with vascular cancer thrombus

Table 1 Univariate analysis of the demographic, clinical, and pathological risk variables in 530 patients with resectable gastric adenocarcinoma accompanied by vascular cancer thrombus

Characteristic	n (%)	χ2	P value
Age, yr
< 60	211 (39.8)	5.943	0.015
≥ 60	319 (60.2)
Sex
Male	423 (79.8)	7.533	0.006
Female	107 (20.2)
Past history
No	289 (54.5)	3.76	0.052
Yes	241 (45.5)
Family history
No	479 (90.4)	4.711	0.030
Yes	51 (9.6)
Preoperative complications
No	458 (86.4)	1.982	0.037
Digestive tract obstruction	41 (7.7)
Alimentary tract hemorrhage	10 (1.9)
Others1	6 (1.1)
≥ 2 complications	15 (2.8)
Surgical method
Open abdominal	328 (61.9)	1.853	0.396
Laparoscopy	179 (33.8)
Joint thoracoabdominal	23 (4.3)
Chemotherapy
No	136 (25.7)	63.834	<0.001
Yes	394 (74.3)
Tumor site
Proximal	286 (54)	2.217	0.330
Distal	144 (27.2)
Body	100 (18.9)
Differentiation
Moderate	54 (10.2)	5.742	0.057
Moderate-poor	188 (35.5)
Poor	288 (54.3)
Lauren classification
Diffused type	182 (34.3)	11.859	0.008
Intestinal type	62 (11.7)
Mixed type	252 (47.5)
NA	34 (6.4)
Neural invasion
Absence	247 (46.6)	5.899	0.015
Presence	283 (53.4)
Tumor size, cm
< 5	231 (43.6)	8.976	0.003
≥ 5	299 (56.4)
HER2 expression
Negative	458 (86.4)	0.495	0.482
Positive	72 (13.6)
MMR status
dMMR	14 (2.6)	0.229	0.633
pMMR	516 (97.4)
Ki-67 expression
Low	8 (1.5)	6.019	0.014
High	522 (98.5)
T stage
2	44 (8.5)	25.459	< 0.001
3	374 (70.6)
4a	93 (17.5)
4b	18 (3.4)
N stage
0	37 (7)	42.8	< 0.001
1	104 (19.6)
2	137 (25.8)
3a	158 (29.8)
3b	94 (17.7)
Stage
IB	10 (1.9)	62.765	< 0.001
IIA	43 (8.1)
IIB	80 (15.1)
IIIA	132 (24.9)
IIIB	171 (32.3)
ШC	94 (17.7)

¹Others includes perforation, gastric retention and anemia.

dMMR: Defective mismatch repair; pMMR: Proficient mismatch repair.

Table 2 Univariate and multivariate analyses of 133 patients with stage I and stage II resectable gastric adenocarcinoma accompanied by vascular cancer thrombus to determine which clinicopathological characteristics are risk factors

Characteristic	N	Univariate analysis		Multivariate analysis
		χ2	P value	HR (95%CI)	P value
Preoperative complications
No	115	27.724	< 0.001	1	0.021
Digestive tract obstruction	4			2.15 (0.50-9.32)	0.304
Alimentary tract hemorrhage	1			2.90 (0.38-22.41)	0.307
Others1	3			7.07 (1.91-26.15)	0.003
Neural invasion
Absence	73	10.014	0.002	1
Presence	50			2.47 (1.16-5.28)	0.02
Ki-67 expression
Low	1	5.58	0.018	1
High	122			0.05 (0.01-0.44)	0.007

¹Others includes perforation, gastric retention and anemia.

HR: Hazard ratio; CI: Confidence interval.