Basic Study
Copyright ©The Author(s) 2024.
World J Gastrointest Surg. May 27, 2024; 16(5): 1395-1406
Published online May 27, 2024. doi: 10.4240/wjgs.v16.i5.1395
Table 1 Histological and clinical characteristics of colorectal cancer patients, n (%)
Variable
Value
Gender
    Male112 (54.6)
    Female93 (45.4)
Age (yr)
    ≥ 60106 (51.7)
    < 6099 (48.3)
Primary site
    Colon140 (68.3)
    Rectum65 (31.7)
Tumor type
    Exophytic type151 (73.7)
    Ulcerative type54 (26.3)
LVI
    Present64 (31.2)
    Absent141 (68.8)
PNI
    Present58 (28.3)
    Absent147 (71.7)
EMVI
    Present31 (15.1)
    Absent174 (84.9)
LNM
    Present89 (43.4)
    Absent116 (56.6)
PDC
    Present152 (74.1)
    Absent53 (25.9)
TB
    BD1117 (57.1)
    BD240 (19.5)
    BD348 (23.4)
Histologic differentiation
    P/D or mucinous53 (25.9)
    M/D142 (69.3)
    W/D10 (4.9)
Tumor stage
    I34 (16.6)
    II72 (35.1)
    III80 (39.0)
    IV19 (9.3)
c-MET immunohistochemistry
    03 (1.4)
    1+51 (24.9)
    2+112 (54.7)
    3+39 (19.0)
MET FISH (Cappuzzo criteria)
    MET GCN ≥ 528 (14.4)
    MET GCN < 5167 (85.6)
MET FISH (PathVysion criteria)
    MET/CEP7 ≥ 20 (0.0)
    MET/CEP7 < 2195 (100.0)
Table 2 Correlations between polysomy-caused mesenchymal-epithelial transition factor amplification and clinicopathological characteristics of colorectal cancer patients, n (%)
Characteristic
MET FISH
P value
Positive MET GCN ≥ 5 (n = 28)
Negative MET GCN < 5 (n = 167)
Total (n = 195)
Gender0.975
    Male15 (53.60)90 (53.90)105 (53.80)
    Female13 (12.90)77 (46.21)90 (46.20)
Age (yr)0.085
    ≥ 6019 (67.90)84 (50.30)103 (52.80)
    < 609 (32.10)83 (49.70)92 (47.20)
Primary site0.077
    Colon23 (82.10)109 (65.30)132 (67.70)
    Rectum5 (17.90)58 (34.70)63 (32.30)
Tumor type0.187
    Exophytic type18 (64.30)127 (76.00)145 (74.40)
    Ulcerative type10 (35.70)40 (24.00)50 (25.60)
LVI0.261
    Present11 (39.30)48 (28.70)59 (30.30)
    Absent17 (60.70)119 (71.30)136 (69.70)
PNI0.377
    Present10 (35.70)46 (27.50)56 (28.70)
    Absent18 (64.30)121 (72.50)139 (71.30)
EMVI0.500
    Present6 (21.40)24 (14.40)30 (15.40)
    Absent22 (78.60)143 (85.60)165 (84.60)
LNM< 0.001
    Present21 (75.00)60 (35.90)81 (41.50)
    Absent7 (25.00)107 (64.10)114 (58.50)
PDC0.153
    Present24 (85.70)122 (73.10)146 (74.90)
    Absent4 (14.30)45 (26.90)49 (25.10)
TB0.020
    BD110 (35.70)99 (59.30)109 (55.9)
    BD2/318 (64.30)68 (40.70)86 (44.10)
Histologic differentiation0.933
    P/D or mucinous7 (25.00)43 (25.70)50 (25.60)
    W/D or M/D21 (75.00)124 (74.30)145 (74.40)
Table 3 Correlations between c-mesenchymal-epithelial transition factor protein expression and clinicopathological characteristics of colorectal cancer patients, n (%)
CharacteristicC-MET IHC
P value
0/1+ (n = 54)
2+ (n = 112)
3+ (n = 39)
Total (n = 205)
Gender0.525
    Male33 (61.1)58 (51.8)21 (53.8)112 (54.6)
    Female21 (38.9)54 (48.2)18 (46.2)93 (45.4)
Age (yr)0.138
    ≥ 6033 (61.1)51 (45.4)22 (56.4)106 (51.7)
    < 6021 (38.9)61 (54.5)17 (43.6)99 (48.3)
Primary site0.805
    Colon38 (70.4)77 (68.8)25 (64.1)140 (68.3)
    Rectum16 (29.6)35 (31.3)14 (35.9)65 (31.7)
Tumor type0.656
    Exophytic type39 (72.2)81 (72.3)31 (79.5)151 (73.7)
    Ulcerative type15 (27.8)31 (27.7)8 (20.5)54 (26.3)
LVI0.941
    Present17 (31.5)34 (30.4)13 (33.3)64 (31.2)
    Absent37 (68.5)78 (69.6)26 (66.7)141 (68.8)
PNI0.897
    Present15 (27.8)33 (29.5)10 (25.6)58 (28.3)
    Absent39 (72.2)79 (70.5)29 (74.4)147 (71.7)
EMVI0.252
    Present5 (9.3)21 (18.8)5 (12.8)31 (15.1)
    Absent49 (90.7)91 (81.3)34 (87.2)174 (84.9)
LNM0.002
    Present18 (33.0)156 (50.0)125 (64.1)189 (43.4)
    Absent36 (67.0)156 (50.0)114 (35.9)1116 (56.6)
PDC0.188
    Present35 (64.8)87 (77.7)30 (76.9)152 (74.1)
    Absent19 (35.2)25 (22.3)9 (23.1)53 (25.9)
TB0.148
    BD134 (63.0)66 (58.9)17 (43.6)117 (57.1)
    BD2/320 (37.0)46 (41.1)22 (56.4)88 (42.9)
Histologic differentiation0.541
    P/D or mucinous17 (31.5)27 (24.1)9 (23.1)53 (25.9)
    W/D or M/D37 (68.5)85 (75.9)30 (76.9)152 (74.1)