Prognostic value of a nomogram model for postoperative liver metastasis of colon cancer

Table 1 Comparison of the general data in patients in the transfer and non-transfer groups, n (%)

Considerations	Transfer group (n = 52)	Non-transfer group (n = 190)	t/z/χ2	P value
Age (yr)	58.96 ± 16.59	61.31 ± 14.00	0.93	0.35
BMI (kg/m2)	22.16 ± 3.84	22.56 ± 2.92	0.69	0.50
Sex			1.01	0.32
Male	30 (57.70)	124 (65.30)
Female	22 (42.30)	66 (34.70)
Drinking history			1.41	0.24
Yes	40 (76.90)	130 (68.40)
No	12 (23.10)	60 (31.60)
Smoking history			1.13	0.29
Yes	44 (84.60)	148 (77.90)
No	8 (15.40)	42 (22.10)
Heart disease			0.01	0.93
Yes	14 (26.90)	50 (26.30)
No	38 (73.10)	140 (73.70)
Diabetes			1.58	0.21
Yes	14 (26.90)	36 (18.90)
No	38 (73.10)	154 (81.10)
Hypertension			1.84	0.18
Yes	8 (15.40)	46 (24.20)
No	44 (84.60)	144 (75.80)

BMI: Body mass index.

Table 2 Comparison of the clinical data in the transfer and non-transfer groups

Considerations	Transfer group (n = 52)	Non-transfer group (n = 190)	t/z/χ2	P value
SII	385.21 ± 78.63	264.29 ± 64.43	-10.19	< 0.01
CAR	1.02 ± 0.40	0.79 ± 0.38	-3.88	< 0.01
RDW (FL)	17.64 ± 1.98	16.28 ± 1.26	-4.72	< 0.01
Total bilirubin (µmol/L)	13.45 ± 2.51	13.75 ± 3.28	0.71	0.48
Albumin (g/L)	42.08 ± 3.81	42.22 ± 2.71	0.25	0.80
Blood platelet count (109/L)	167.13 ± 65.02	157.29 ± 40.59	-1.04	0.30
WBC (109/L)	7.48 ± 2.58	7.52 ± 3.12	0.08	0.93
ALT (U/L)	47.88 ± 1.84	48.50 ± 1.59	2.40	0.017
AST (U/L)	47.29 ± 1.25	47.14 ± 1.76	-0.61	0.54
Surgical procedures			0.01	0.94
Laparoscopy	32 (61.50)	118 (62.10)
Open the abdomen	20 (38.50)	72 (37.90)	0.01	0.93
Vascular invasion			3.26	0.07
Yes	24 (46.20)	62 (32.60)
No	28 (53.80)	128 (67.40)	1.58	0.21
Tumor site			1.01	0.32
Left	30 (57.70)	124 (65.30)
Right	22 (42.30)	66 (34.70)
Pathological type			1.05	0.31
Adenocarcinoma	48 (92.30)	182 (95.80)
Other	4 (7.70)	8 (4.20)
Postoperative chemotherapy			3.26	0.07
Yes	24 (46.20)	62 (32.60)
No	28 (53.80)	128 (67.40)
Preoperative CEA (μg/L)			9.59	< 0.01
< 5	21 (40.40)	122 (64.20)
≥ 5	31 (59.60)	68 (35.80)
Lymphatic node transfer			4.90	0.03
Yes	28 (53.80)	70 (36.80)
No	24 (46.20)	120 (63.20)

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; CAR: C-reactive protein/albumin ratio; CEA: Carcinoembryonic antigen; RDW: Red blood cell distribution width; SII: Systemic inflammatory index; WBC: White blood cell.

Table 3 Variable assignment table

Project	Assignment description
Dependent variable	Transfer group '1', Non-transfer group '0'
SII	Continuous variable
CAR	Continuous variable
RDW	Continuous variable
ALT	Continuous variable
Preoperative CEA	≥ 5 μg/L '1', < 5 μg/L '0'
Lymphatic node transfer	Yes '1', No '0'

ALT: Alanine aminotransferase; CAR: C-reactive protein/albumin ratio; CEA: Carcinoembryonic antigen; RDW: Red blood cell distribution width; SII: Systemic inflammatory index.

Table 4 Multifactorial analysis of liver metastases after surgery for colon cancer

Considerations	β	SE	Wald χ2	P value	OR	95%CI
SII	0.26	< 0.01	36.78	< 0.01	1.03	1.02-1.03
CAR	1.57	0.56	7.74	0.01	4.79	1.59-14.44
RDW	0.57	0.15	13.77	< 0.01	1.76	1.31-2.38
ALT	-0.25	0.15	2.87	0.09	0.78	0.58-1.04
Preoperative CEA	0.85	0.48	3.09	0.08	2.34	0.91-6.04
Lymphatic node transfer	0.7	0.49	2.04	0.15	2.01	0.77-5.23
Constant	-9.17	7.71	1.41	0.24	< 0.01	-

ALT: Alanine aminotransferase; CAR: C-reactive protein/albumin ratio; Carcinoembryonic antigen; RDW: Red blood cell distribution width; SII: Systemic inflammatory index.

Table 5 Predictive value of systemic inflammatory index, lymphatic metastasis, C-reactive protein/albumin ratio, and red blood cell distribution width in patients with postoperative liver metastasis

Considerations	Truncation value	AUC	SE	P value	95%CI	Sensitivity (%)	Idiosyncrasy (%)
SII	290.52	0.88	0.03	< 0.01	0.83-0.94	96.2	71.6
CAR	0.86	0.68	0.04	< 0.01	0.60-0.76	65.4	67.2
RDW	16.76	0.67	0.04	< 0.01	0.59-0.76	50	87.4

CAR: C-reactive protein/albumin ratio; RDW: Red blood cell distribution width; SII: Systemic inflammatory index; AUC: Area under the curve.