Construction and validation of somatic mutation-derived long non-coding RNAs signatures of genomic instability to predict prognosis of hepatocellular carcinoma

Table 1 Univariate and multivariate Cox regression analysis were performed for the risk score models which were based on the genomic instability-derived long non-coding RNAs signature and the overall survival of each patient group

Variables	Univariate model				Multivariate model
	HR	HR.95L	HR.95H	P value	HR	HR.95L	HR.95H	P value
Training set (n = 172)
Age	1.006525828	0.98572802	1.02776245	0.541469061
Gender	0.807010011	0.462541245	1.40801532	0.450226707
Grade	1.042610761	0.723413296	1.50265029	0.822943265
Stage	1.761758723	1.309037988	2.37104945	0.000186258	1.659300183	1.22204964	2.252999	0.001175
GILncSig (risk score)	1.188529556	1.113059499	1.26911679	2.47E-07	1.162772947	1.0877837	1.242932	9.26E-06
Testing set (n = 171)
Age	1.004801347	0.984472975	1.02554948	0.646002639
Gender	0.698036023	0.401683709	1.21302975	0.202306355
Grade	1.239812446	0.8513541	1.80551771	0.262350748
Stage	1.847252215	1.362695682	2.50411063	7.70E-05
GILncSig (risk score)	1.006092566	0.964257819	1.04974233	0.779239112	1.847252215	1.36269568	2.504111	7.70E-05
TCGA set (n = 343)
Age	1.005264743	0.990686911	1.02005709	0.481098302
Gender	0.757517136	0.513257347	1.11802045	0.162034315
Grade	1.121252512	0.864806496	1.45374393	0.387728497
Stage	1.807719072	1.462607075	2.23426257	4.31E-08
GILncSig (risk score)	1.026022708	0.998101217	1.05472529	0.068008495	1.807719072	1.46260708	2.234263	4.31E-08

GILncSig: Genomic instability-derived long non-coding RNAs signature.