Correlation between serum markers and transjugular intrahepatic portosystemic shunt prognosis in patients with cirrhotic ascites

Table 1 Comparison of clinical data between the two groups

Group		Survival group (n = 45 cases)	Deceased group (n = 30 cases)	t/χ2	P value
Age (yr)		51.42 ± 7.28	53.25 ± 7.09	1.078	0.285
Sex	Male	26	16	0.144	0.704
	Female	19	14
Combined background disease	Presence	15	12	0.347	0.556
	Absence	30	18
Family history	Presence	4	5	1.031	0.310
	Absence	41	25
Smoking history	Presence	12	11	0.847	0.358
	Absence	33	19
Drinking history	Presence	10	10	1.136	0.286
	Absence	35	20
AST (U/L)		54.29 ± 11.57	60.72 ± 14.09	2.160	0.034
ALT (U/L)		40.31 ± 9.86	45.19 ± 10.52	2.044	0.045
ALP (U/L)		121.90 ± 30.37	129.74 ± 32.37	1.067	0.290
GGT (U/L)		64.86 ± 16.25	70.38 ± 18.39	1.367	0.176
Tbil (μmol/L)		44.93 ± 13.64	54.07 ± 16.76	2.593	0.012
Alb (g/L)		29.52 ± 8.53	24.67 ± 7.91	2.482	0.015
Scr (μmol/L)		66.04 ± 10.38	72.21 ± 12.86	2.290	0.025
BUN (μmol/L)		7.23 ± 2.07	7.41 ± 2.18	0.361	0.719
Na+ (mmol/L)		136.24 ± 18.67	126.74 ± 12.35	2.450	0.017
PLT (× 109/L)		60.03 ± 12.47	56.42 ± 10.19	1.318	0.192
PT (s)		16.12 ± 3.09	17.83 ± 2.83	2.427	0.018
Cys C (mg/L)		1.68 ± 0.36	2.43 ± 0.47	7.813	0.000
INR		1.57 ± 0.32	1.84 ± 0.39	3.278	0.002
Child-Pugh score (points)		10.09 ± 1.45	12.87 ± 1.29	8.494	0.000
MELD score (points)		11.58 ± 2.34	17.46 ± 2.98	9.547	0.000

MELD: Model for end-stage liver disease; Cys C: Cystatin C; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transferase; TBil: Total bilirubin; PT: Prothrombin time; PLT: Blood platelet count; BUN: Blood urea nitrogen; Alb: Albumin; Scr: Serum creatinine; INR: International normalized ratio.

Table 2 Spearman analysis of the correlation between prognosis and Child-Pugh score, model for end-stage liver disease score, and cystatin C level

Indicator	Child-Pugh scores		MELD scores		Cys C
	r	P value	r	P value	r	P value
Prognosis	0.709	0.000	0.749	0.000	0.670	0.000

MELD: Model for end-stage liver disease; Cys C: Cystatin C.

Table 3 Multiple factor analysis utilizing the Cox proportional hazard model for identifying independent risk factors influencing the prognosis of patients with liver cirrhosis and refractory ascites following transjugular intrahepatic portosystemic shunt

Factor	B	Sb	Wald χ2	P value	HR (95%CI)
AST	-0.022	0.017	1.627	0.202	0.978 (0.946-1.012)
ALT	0.041	0.027	2.320	0.128	1.042 (0.988-1.099)
TBil	-0.017	0.016	1.179	0.278	0.983 (0.953-1.014)
Alb	-0.012	0.033	0.131	0.717	0.988 (0.927-1.054)
Scr	-0.042	0.023	3.243	0.072	0.959 (0.916-1.004)
Na+	-0.028	0.021	1.766	0.184	0.972 (0.933-1.013)
PT	0.001	0.095	0.000	0.991	1.001 (0.831-1.206)
Cys C	1.336	0.543	6.057	0.014	3.802 (1.313-11.015)
INR	1.282	0.714	3.228	0.072	3.604 (0.890-14.597)
Child-Pugh scores	1.109	0.250	19.723	0.000	3.030 (1.858-4.943)
MELD scores	0.201	0.067	9.099	0.003	1.222 (1.073-1.393)

MELD: Model for end-stage liver disease; Cys C: Cystatin C; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transferase; TBil: Total bilirubin; PT: Prothrombin time; PLT: Blood platelet count; BUN: Blood urea nitrogen; Alb: Albumin; Scr: Serum creatinine; INR: International normalized ratio.

Table 4 Receiver operating characteristic analysis for single risk factors predicting the post-transjugular intrahepatic portosystemic shunt prognosis of patients with refractory ascites due to liver cirrhosis

Risk factor	ROC curve			Optimal cutoff value	Sensitivity (%)	Specificity (%)
	AUC	95%CI	P value
Cys C	0.883	0.803-0.963	0.000	1.95 mg/L	83.33 (25/30)	82.22 (37/45)
Child-Pugh scores	0.919	0.856-0.981	0.000	11.50 points	90.00 (27/30)	84.44 (38/45)
MELD scores	0.934	0.879-0.988	0.000	13.50 points	86.67 (26/30)	82.22 (37/45)

ROC: Receiver operating characteristic; MELD: Model for end-stage liver disease; Cys C: Cystatin C; AUC: Area under the curve.