Relationship between intracranial pressure and neurocognitive function among older adults after radical resection of rectal cancer

Table 1 The age, weight, time of surgery, intraoperative blood loss, and urine output of the two groups of patients

Item	Group A1	Group A2	F	P value
Age	67.83 ± 2.09	68.49 ± 1.57	3.64	0.059
Weight (kg)	57.35 ± 2.19	57.29 ± 1.65	0.026	0.873
Time of surgery (minutes)	222.50 ± 11.82	224.17 ± 12.54	0.471	0.494
Intraoperative blood loss (mL)	150.33 ± 12.14	153.16 ± 15.75	0.968	0.328
Urine volume (mL)	376.86 ± 14.03	381.78 ± 22.84	1.555	0.215

Table 2 Statistical analysis of Mini-Mental State Examination score and confusion assessment method score of two groups

	Timepoints/ANOVA factors	Group A1	Group A2	F value	P value
CAM	1 day before surgery	10.98 ± 1.00	11.08 ± 0.99	0.272	0.603
	1 day after surgery	14.93 ± 0.81	12.37 ± 1.64	88.2	< 0.001
	4 days after surgery	16.62 ± 1.78	14.62 ± 1.38	41.736	< 0.001
	7 days after surgery	12.93 ± 0.92	12.76 ± 0.61	1.239	0.268
	Time effect			213.73a	0.012a
	Group effect			66.18a	0.031a
	Interaction effect			21.41a	0.022a
MMSE	1 day before surgery	29.29 ± 0.51	29.37 ± 0.60	0.493	0.484
	1 day after surgery	23.79 ± 1.32	27.97 ± 1.26	268.665	< 0.001
	4 days after surgery	24.64 ± 1.10	28.08 ± 0.79	347.358	< 0.001
	7 days after surgery	28.74 ± 1.06	28.89 ± 0.88	0.626	0.431
	Time effect			261.59	0.003
	Group effect			312.85	0.025
	Interaction effect			113.94	0.025

^aP value of Mauchly’s spherical test is less than 0.05, and the F value or P value has been corrected by Greenhouse-Geisser. The P value of the group effect of the above indicators is less than 0.05, indicating that the group A1 and A2 have statistically significant differences in the effects of confusion assessment method and Mini-Mental State Examination. In addition, the P value of the interaction effect of confusion assessment method and Mini-Mental State Examination is less than 0.05, and the individual effect is reflected in the statistical difference at t2 and t3.

CAM: Confusion assessment method; MMSE: Mini-Mental State Examination.

Table 3 Comparison of h1, h2, h3, h4, mean arterial pressure, heart rate and end-tidal carbon dioxide partial pressure between the two groups

	Timepoints/ANOVA factors	Group A1	Group A2	F value	P value
MAP	Before anesthesia	75.60 ± 2.33	76.40 ± 1.93	3.68	0.058
	30 minutes after the Trendelenburg position	90.19 ± 1.55	77.11 ± 1.28	2212.42	< 0.001
	60 minutes after the Trendelenburg position	91.62 ± 1.34	78.41 ± 1.55	2028.42	< 0.001
	After extubation	78.74 ± 1.11	78.59 ± 0.93	0.571	0.452
	Time effect			703.67a	0.024a
	Group effect			993.59a	0.014a
	Interaction effect			535.37a	0.033a
HR	Before anesthesia	81.95 ± 2.24	82.40 ± 1.62	1.39	0.241
	30 minutes after the Trendelenburg position	75.26 ± 1.62	75.81 ± 1.96	2.251	0.137
	60 minutes after the Trendelenburg position	73.79 ± 2.07	74.70 ± 2.54	3.752	0.055
	After extubation	85.14 ± 1.76	85.79 ± 2.35	2.342	0.129
	Time effect			592.05	0.015
	Group effect			7.59	0.011
	Interaction effect			0.07	0.981
PETCO2	Before anesthesia	31.07 ± 1.09	30.70 ± 1.35	2.229	0.139
	30 minutes after the Trendelenburg position	41.05 ± 1.06	40.76 ± 1.19	1.589	0.211
	60 minutes after the Trendelenburg position	42.38 ± 0.49	41.97 ± 1.78	2.148	0.146
	After extubation	34.43 ± 1.35	34.24 ± 1.47	0.453	0.502
	Time effect			1553.13	0.004
	Group effect			4.61	0.041
	Interaction effect			0.16	0.921

^aP value of Mauchly’s spherical test is less than 0.05, and the F value or P value has been corrected by Greenhouse-Geisser. The P value of the group effect of the above indicators is less than 0.05, indicating that the group A1 and A2 have statistically significant differences in the effects of mean arterial pressure, heart rate and end-tidal carbon dioxide partial pressure.

MAP: Mean arterial pressure; HR: Heart rate; PETCO₂: End-tidal carbon dioxide partial pressure.