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©The Author(s) 2023.
World J Gastrointest Surg. Sep 27, 2023; 15(9): 2052-2062
Published online Sep 27, 2023. doi: 10.4240/wjgs.v15.i9.2052
Published online Sep 27, 2023. doi: 10.4240/wjgs.v15.i9.2052
Table 1 Patient characteristics
Characteristic | Number of patients | Percentage |
Total patients | 100 | 100% |
Men | 57 | 57% |
Women | 43 | 43% |
Tumour location | ||
Rectum | 52 | 52% |
Sigmoid colon | 26 | 26% |
Ascending colon | 12 | 12% |
Descending colon | 10 | 10% |
Tumour stage | ||
Stage I | 21 | 21% |
Stage II | 29 | 29% |
Stage III | 35 | 35% |
Stage IV | 15 | 15% |
Metastasis | ||
Lymph node metastasis | 50 | 50% |
Distant metastasis | 15 | 15% |
Table 2 Correlations between contrast-enhanced ultrasound parameters and angiogenesis markers
Parameters | Pearson correlation coefficient (r) | P value |
PI and VEGF | 0.73 | < 0.001 |
PI and MVD | 0.75 | < 0.001 |
TTP and VEGF | -0.68 | < 0.001 |
TTP and MVD | -0.72 | < 0.001 |
AUC and VEGF | 0.71 | < 0.001 |
AUC and MVD | 0.74 | < 0.001 |
Table 3 Associations between contrast-enhanced ultrasound parameters, angiogenesis markers, and clinicopathological characteristics
Tumour stage | Lymph node metastasis | Distant metastasis | Age (yr) | Sex | |
PI | P < 0.001 | P < 0.001 | P < 0.001 | NS | NS |
TTP | P < 0.001 | P < 0.001 | P < 0.001 | NS | NS |
AUC | P < 0.001 | P < 0.001 | P < 0.001 | NS | NS |
VEGF expression | P < 0.001 | P < 0.001 | P < 0.001 | NS | NS |
MVD | P < 0.001 | P < 0.001 | P < 0.001 | NS | NS |
Table 4 Multivariate analysis of prognostic factors for overall survival and disease-free survival
Prognostic factor | Hazard ratio (OS) | 95%CI (OS) | P value (OS) | Hazard ratio (DFS) | 95%CI (DFS) | P value (DFS) |
VEGF expression | 2.47 | 1.31-4.65 | 0.005 | 2.31 | 1.24-4.32 | 0.008 |
MVD | 2.81 | 1.49-5.30 | 0.001 | 2.67 | 1.42-5.03 | 0.002 |
PI | 2.55 | 1.36-4.78 | 0.003 | 2.38 | 1.28-4.42 | 0.006 |
TTP | 2.34 | 1.24-4.41 | 0.008 | 2.26 | 1.20-4.26 | 0.011 |
AUC | 2.62 | 1.38-4.96 | 0.003 | 2.54 | 1.34-4. 81 | 0.004 |
- Citation: Li MH, Li WW, He L, Li JF, Zhang SY. Quantitative evaluation of colorectal tumour vasculature using contrast-enhanced ultrasound: Correlation with angiogenesis and prognostic significance. World J Gastrointest Surg 2023; 15(9): 2052-2062
- URL: https://www.wjgnet.com/1948-9366/full/v15/i9/2052.htm
- DOI: https://dx.doi.org/10.4240/wjgs.v15.i9.2052