Autologous bone marrow infusion via portal vein combined with splenectomy for decompensated liver cirrhosis: A retrospective study

Table 1 Comparison of general baseline data between control and intervention groups

Group	Sex (M/F)	Age (yr)	Etiology				Child-Pugh grade
			Hepatitis B cirrhosis	Alcoholic cirrhosis	Hepatitis C cirrhosis	Schistosomiasis cirrhosis	B	C
Control	27/13	47.53 ± 9.21	30	1	6	3	36	4
Intervention	25/18	47.53 ± 8.51	30	3	5	5	41	2
χ2/t	0.428	0.000	1.484				0.266
P value	0.513	0.999	0.686				0.606

M: Male; F: Female.

Table 2 Serum prothrombin time levels in control and intervention groups before and after autologous bone marrow infusion

Group	Before	1 mo	t/P value	3 mo	t/P value	6 mo	t/P value	12 mo	t/P value
Control	19.42 ± 3.95	17.55 ± 2.42	5.603/0.000	16.16 ± 1.82	5.811/0.000	15.26 ± 1.81	8.008/0.000	14.42 ± 1.80	9.909/0.000
Intervention	19.50 ± 3.89	17.55 ± 2.39	6.053/0.000	16.15 ± 2.13	8.780/0.000	15.13 ± 2.03	10.528/0.000	14.43 ± 2.10	11.755/0.000
t	0.089	0.005		0.018		0.317		0.009
P value	0.929	0.996		0.986		0.752		0.993

Results are expressed as s mean ± SD.

Table 3 Serum albumin levels in control and intervention groups before and after autologous bone marrow infusion (mean ± SD, g/L)

Group	Before	1 mo	t/P value	3 mo	t/P value	6 mo	t/P value	12 mo	t/P value
Control	29.45 ± 4.26	35.05 ± 3.45	16.560/0.000	37.13 ± 3.20	12.024/0.000	39.55 ± 2.33	14.535/0.000	40.24 ± 2.24	18.460/0.000
Intervention	29.38 ± 4.16	34.83 ± 3.54	17.465/0.000	36.85 ± 3.70	18.241/0.000	38.25 ± 3.97	17.519/0.000	39.53 ± 3.28	19.131/0.000
t	0.076	0.287		0.359		0.980		1.114
P value	0.940	0.775		0.721		0.330		0.369

Results expressed as mean ± SD (g/L).

Table 4 The serum total bilirubin levels in control and intervention groups before and after autologous bone marrow infusion

Group	Before	1 mo	t/P value	3 mo	t/P value	6 mo	t/P value	12 mo	t/P value
Control	44.89 ± 20.56	35.11 ± 15.20	6.536/0.000	29.95 ± 12.69	7.379/0.000	27.26 ± 11.77	7.896/0.000	24.29 ± 8.57	8.255/0.000
Intervention	42.90 ± 19.77	31.48 ± 14.12	7.534/0.000	27.58 ± 12.55	9.014/0.000	26.05 ± 11.02	9.021/0.000	23.65 ± 8.44	9.120/0.000
t	0.437	1.093		0.830		0.470		0.332
P value	0.663	0.278		0.409		0.640		0.741

Results expressed as mean ± SD (µmol/L).

Table 5 Ascites volume in control and intervention groups before and after autologous bone marrow infusion

Group	Before	1 mo	Z/P value	3 mo	Z/P value	6 mo	Z/P value	12 mo	Z/P value
Control	3000 (1500-4125)	1000 (0-2000)	5.386/0.000	500 (0-1500)	5.388/0.000	250 (0-1125)	5.392/0.000	0 (0-1000)	5.394/0.000
Intervention	3000 (1500-4000)	750 (0-1875)	5.519/0.000	0 (0-500)	5.519/0.000	0 (0-500)	5.525/0.000	0 (0-500)	5.457/0.000
Z	0.226	0.780		1.379		1.353		1.374
P value	0.790	0.436		0.168		0.176		0.170

Results expressed as M (P₂₅-P₇₅) (mL).

Table 6 Comparison of model for end-stage liver disease scores in two groups before and after autologous bone marrow infusion

Group	Before	1 mo	t/P value	3 mo	t/P value	6 mo	t/P value	12 mo	t/P value
Control	21.53 ± 6.17	18.87 ± 5.09	2.050/0.044	17.73 ± 6.42	2.631/0.010	13.76 ± 5.51	5.790/0.000	12.58 ± 4.64	7.147/0.000
Intervention	22.61 ± 5.61	18.92 ± 4.85	3.147/0.002	16.67 ± 5.75	4.677/0.000	15.42 ± 5.61	5.732/0.000	11.94 ± 5.00	8.980/0.000
t	0.804	0.044		0.770		1.325		0.577
P value	0.424	0.965		0.443		0.189		0.566

Results are expressed as mean ± SD.

Table 7 Comparison of white blood cell in control and intervention groups before and after autologous bone marrow infusion

Group	Before	1 mo	t/P value	3 mo	t/P value	6 mo	t/P value	12 mo	t/P value
Control	3.14 ± 0.76	5.17 ± 1.32	12.975/0.000	3.42 ± 0.98	3.363/0.002	3.27 ± 0.93	2.311/0.026	3.33 ± 0.82	3.505/0.001
Intervention	3.20 ± 1.17	8.00 ± 1.28	23.457/0.000	6.44 ± 1.54	11.474/0.000	6.15 ± 1.37	13.409/0.000	5.89 ± 0.97	13.776/0.000
t	0.258	9.625		10.211		10.768		12.531
P value	0.797	0.000		0.000		0.000		0.000

Results expressed as mean ± SD (cell count × 10⁹/L).

Table 8 Comparison of platelet counts in control and intervention groups before and after autologous bone marrow infusion

Group	Before	1 mo	t/P value	3 mo	t/P value	6 mo	t/P value	12 mo	t/P value
Control	42.82 ± 12.66	44.64 ± 13.08	2.776/0.009	45.79 ± 12.67	3.433/0.001	47.45 ± 12.02	5.037/0.000	49.26 ± 13.37	5.093/0.0000
Intervention	44.30 ± 13.51	231.63 ± 57.78	22.601/0.000	226.50 ± 47.92	27.006/0.000	226.68 ± 41.32	31.942/0.000	222.90 ± 39.36	32.647/0.000
t	0.500	19.475		22.503		25.719		25.812
P value	0.618	0.000		0.000		0.000		0.000

Results expressed as mean ± SD (cell count × 10⁹/L).

Table 9 Comparison of hemoglobin levels in control and intervention groups before and after autologous bone marrow infusion

Group	Before	1 mo	t/P value	3 mo	t/P value	6 mo	t/P value	12 mo	t/P value
Control	94.74 ± 20.86	95.03 ± 19.39	0.387/0.701	99.47 ± 19.12	4.211/0.000	102.84 ± 18.11	6.286/0.000	104.13 ± 17.19	7.498/0.000
Intervention	97.48 ± 23.20	97.03 ± 20.19	0.394/0.696	106.70 ± 18.97	6.716/0.000	113.08 ± 16.69	9.445/0.000	117.33 ± 11.70	8.318/0.000
t	0.547	0.446		1.675		2.596		3.980
P value	0.586	0.657		0.098		0.011		0.000

Results expressed as mean ± SD (g/L).

Table 10 Comparison of CD4⁺ T cell count in control and intervention groups before and after autologous bone marrow infusion

Group	Before	1 mo	t/P value	3 mo	t/P value	6 mo	t/P value	12 mo	t/P value
Control	432 ± 190	432 ± 183	0.384/0.703	440 ± 184	2.805/0.008	445 ± 189	5.259/0.000	447 ± 186	4.796/0.000
Intervention	436 ± 243	487 ± 227	9.029/0.000	492 ± 219	8.140/0.000	507 ± 223	10.150/0.000	510 ± 213	8.566/0.000
t	0.106	1.177		1.148		1.329		1.400
P value	0.916	0.243		0.255		0.188		0.166

Results expressed as mean ± SD (cells/µL).

Table 11 Comparison of CD8⁺ T cell count in control and intervention groups before and after autologous bone marrow infusion

Group	Before	1 mo	t/P value	3 mo	t/P value	6 mo	t/P value	12 mo	t/P value
Control	338 ± 210	349 ± 215	2.961/0.000	361 ± 211	4.917/0.000	363 ± 213	3.432/0.001	356 ± 204	1.092/0.282
Intervention	328 ± 210	357 ± 211	9.594/0.000	376 ± 210	10.948/0.000	396 ± 212	12.880/0.000	408 ± 207	12.709/0.000
t	0.206	0.169		0.328		0.684		1.119
P value	0.837	0.866		0.744		0.496		0.267

Results expressed as mean ± SD (cells/µL).