Risk factors and their interactive effects on severe acute pancreatitis complicated with acute gastrointestinal injury

Table 1 Comparison of clinical and laboratory data between the two groups, n (%)

Influencing factors	AGI group (n = 64)	Non-AGI group (n = 104)	χ2/t	P value
Gender			0.464	0.496
Male	31 (48.44)	56 (53.85)
Female	33 (51.56)	48 (4 6.15)
Age (mean ± SD, yr)	50.16 ± 7.56	49.42 ± 8.12	0.583	0.560
Hypertension			0.168	0.682
Yes	31 (48.44)	47 (45.19)
No	33 (51.56)	57 (54.81)
Diabetes			0.101	0.751
Yes	33 (51.56)	51 (49.04)
No	31 (48.44)	53 (50.96)
Coronary heart disease			0.008	0.927
Yes	34 (53.13)	56 (53.85)
No	30 (46.87)	48 (46.15)
Smoking			0.059	0.809
Yes	32 (50.00)	54 (51.92)
No	32 (50.00)	50 (48.08)
MODS			21.263	< 0.001
Yes	43 (67.19)	32 (30.77)
No	21 (32.81)	72 (69.23)
APACHE II score (mean ± SD)	17.45 ± 4.74	10.79 ± 3.95	-9.836	< 0.001
Leukocytes (mean ± SD, × 109/L)	15.12 ± 3.03	13.87 ± 2.27	-2.834	0.006
Hemoglobin (mean ± SD, g/L)	140.87 ± 14.93	144.50 ± 15.87	1.470	0.143
Creatinine (mean ± SD, µmol/L)	115.15 ± 12.18	93.07 ± 10.22	-12.116	< 0.001
Amylase (mean ± SD, U/L)	761.43 ± 73.90	751.20 ± 70.95	-0.894	0.373
Total bilirubin (mean ± SD, µmol/L)	22.09 ± 3.68	21.78 ± 3.61	-0.529	0.597

AGI: Acute gastrointestinal injury; MODS: Multiple organ dysfunction syndrome; APACHE II: Acute physiological and chronic health scoring system II.

Table 2 Factor assignment for logistic regression analysis

Influencing factors	Assignment of factors
Presence or absence of AGI	0 = Non-AGI group, 1 = AGI group
MODS	0 = no, 1 = yes
APACHE II	≤ 15 points = 0, > 15 points = 1
Creatinine	≤ 100 µmol/L = 0, > 100 µmol/L = 1
Leukocytes	Original value input

AGI: Acute gastrointestinal injury; MODS: Multiple organ dysfunction syndrome; APACHE II: Acute physiological and chronic health scoring system II.

Table 3 Logistic regression analysis of severe acute pancreatitis patients with acute gastrointestinal injury

Influencing factors	B value	SE value	Wald value	P value	OR (95%CI)
APACHE II	1.716	0.613	7.820	0.005	5.560 (1.671-18.502)
MODS	-0.398	0.598	0.442	0.506	0.672 (0.208-2.169)
Leukocytes	0.196	0.101	3.769	0.052	1.216 (0.998-1.482)
Creatinine	3.380	0.553	37.366	< 0.001	29.365 (9.936-86.788)

MODS: Multiple organ dysfunction syndrome; APACHE II: Acute physiological and chronic health scoring system II.

Table 4 Interaction of creatinine and acute physiological and chronic health scoring system II score on acute gastrointestinal injury in severe acute pancreatitis patients

APACHE II	Creatinine	AGI group	Non-AGI group	OR	95%CI	RERI	API	S
		1	79	1.00		220.059	0.678	3.123
+		5	4	98.75	9.228-1056.778
	+	21	12	138.25	16.998-1124.444
+	+	37	9	0.024	0.002-0.314

AGI: Acute gastrointestinal injury; APACHE II: Acute physiological and chronic health scoring system II; API: Attributable proportion of interaction; RERI: Relative excess risk of interaction.