High spindle and kinetochore-associated complex subunit-3 expression predicts poor prognosis and correlates with adverse immune infiltration in hepatocellular carcinoma

Table 1 Clinical characteristics of hepatocellular carcinoma patients in The Cancer Genome Atlas database, n (%)

Characteristic	Low expression of SKA3	High expression of SKA3	P value
	n = 187	n = 187
Age			0.034
≤ 60	78 (44.1)	99 (55.9)
> 60	109 (55.6)	87 (44.4)
Sex			0.269
Female	55 (45.5)	66 (54.5)
Male	132 (52.2)	121 (47.8)
Race			0.008
Asian	65 (40.6)	95 (59.4)
Black or African American	9 (52.9)	8 (47.1)
White	106 (57.3)	79 (42.7)
T stage			0.031
T1	105 (57.4)	78 (42.6)
T2	41 (43.2)	54 (56.8)
T3	33 (41.2)	47 (58.8)
T4	5 (38.5)	8 (61.5)
N stage			1.000
N0	119 (46.9)	135 (53.1)
N1	2 (50)	2 (50)
M stage			0.355
M0	128 (47.8)	140 (52.2)
M1	3 (75)	1 (25)
AFP (ng/mL)			< 0.001
≤ 400	124 (57.7)	91 (42.3)
> 400	17 (26.2)	48 (73.8)
Child-Pugh grade			0.813
A	118 (53.9)	101 (46.1)
B	10 (47.6)	11 (52.4)
C	1 (100)	0 (0)
Pathologic stage			0.024
Stage I	98 (56.6)	75 (43.4)
Stage II	39 (44.8)	48 (55.2)
Stage III	34 (40)	51 (60)
Stage IV	4 (80)	1 (20)
Vascular invasion			0.121
No	115 (55.3)	93 (44.7)
Yes	50 (45.5)	60 (54.5)

HCC: Hepatocellular carcinoma; SKA3: Spindle and kinetochore-associated complex subunit 3; AFP: Alpha fetoprotein.