Dissimilar survival and clinicopathological characteristics of mucinous adenocarcinoma located in pancreatic head and body/tail

Table 1 Baseline characteristics of two patient groups, n (%)

	PBTG (n = 112)	PHG (n = 159)	Overall (n = 271)	P value
Age, yr
< 65	39 (34.8)	66 (41.5)	105 (38.7)	0.538
≥ 65	73 (65.2)	93 (58.5)	166 (61.3)
Race
Black	15 (13.4)	17 (10.7)	32 (11.8)	0.443
Other	20 (17.9)	17 (10.7)	37 (13.7)
White	77 (68.8)	125 (78.6)	202 (74.5)
Sex
Female	67 (59.8)	65 (40.9)	132 (48.7)	0.009
Male	45 (40.2)	94 (59.1)	139 (51.3)
Grade
G1 + G2	35 (31.3)	70 (44.0)	105 (38.7)	0.041
G3 + G4	11 (9.8)	26 (16.4)	37 (13.7)
Unknown	66 (58.9)	63 (39.6)	129 (47.6)
Stage
I	10 (8.9)	18 (11.3)	28 (10.3)	< 0.001
II	28 (25.0)	82 (51.6)	110 (40.6)
III	9 (8.0)	6 (3.8)	15 (5.5)
IV	65 (58.0)	53 (33.3)	118 (43.5)
T
T1	11 (9.8)	15 (9.4)	26 (9.6)	0.209
T2	26 (23.2)	34 (21.4)	60 (22.1)
T3	49 (43.8)	93 (58.5)	142 (52.4)
T4	26 (23.2)	16 (10.1)	42 (15.5)
T0	0 (0)	1 (0.6)	1 (0.4)
N
N0	67 (59.8)	83 (52.2)	150 (55.4)	0.462
N1	45 (40.2)	76 (47.8)	121 (44.6)
M
M0	47 (42.0)	106 (66.7)	153 (56.5)	< 0.001
M1	65 (58.0)	53 (33.3)	118 (43.5)
Primary malignancy
No	23 (20.5)	36 (22.6)	59 (21.8)	0.918
Yes	89 (79.5)	123 (77.4)	212 (78.2)
OS, mo
mean (SD)	14.6 (18.5)	24.1 (21.2)	20.2 (20.6)	< 0.001
Median [Min, Max]	7.50 [0, 87.0]	18.0 [0, 95.0]	13.0 [0, 95.0]

PBTG: Pancreatic body/tail group; PHG: Pancreatic head group.

Table 2 Cox regression analysis of overall survival in patients with pancreatic mucinous adenocarcinoma

Characteristics	Univariate			Multivariate
	HR	95%CI	P value	HR	95%CI	P value
Age, yr
< 65	Reference			Reference
≥ 65	1.62	1.23-2.14	0.001	1.42	1.06-1.89	0.017
Race
Black	Reference
Other	0.91	0.54-1.53	0.725
White	0.94	0.62-1.41	0.751
Sex
Female	Reference			Reference
Male	0.68	0.52-0.89	0.004	0.81	0.61-1.07	0.134
Location
Pancreas body/tail	Reference			Reference
Pancreas head	0.61	0.47-0.8	< 0.001	0.76	0.57-1.01	0.057
Grade
G1 + G2	Reference			Reference
G3 + G4	1.82	1.21-2.73	0.004	2.17	1.43-3.31	< 0.001
Unknown	2.21	1.64-2.97	< 0.001	1.23	0.89-1.69	0.216
Stage
I	Reference			Reference
II	2.39	1.3-4.37	0.005	3.2	1.73-5.92	< 0.001
III	6.2	2.81-13.68	< 0.001	6.5	2.89-14.61	< 0.001
IV	6.73	3.67-12.37	< 0.001	6.2	3.34-11.5	< 0.001
Systemic therapy
No	Reference			Reference
Yes	0.32	0.24-0.44	< 0.001	0.39	0.27-0.56	< 0.001

HR: Hazard ratio; CI: Confidence interval.

Table 3 Cox regression analysis of cancer-specific survival in patients with pancreatic mucinous adenocarcinoma

Characteristics	Univariate			Multivariate
	HR	95%CI	P value	HR	95%CI	P value
Age, yr
< 65	Reference			Reference
≥ 65	1.56	1.17-2.08	0.002	1.37	1.02-1.84	0.038
Race
Black	Reference
Other	0.91	0.54-1.55	0.739
White	0.89	0.58-1.34	0.568
Sex
Female	Reference			Reference
Male	0.64	0.48-0.84	0.001	0.77	0.58-1.03	0.082
Location
Pancreas body/tail	Reference			Reference
Pancreas head	0.56	0.43-0.74	< 0.001	0.7	0.52-0.94	0.017
Grade
G1 + G2	Reference			Reference
G3 + G4	1.75	1.14-2.67	0.01	2.2	1.42-3.4	< 0.001
Unknown	2.12	1.56-2.88	< 0.001	1.1	0.79-1.54	0.559
Stage
I	Reference			Reference
II	3.7	1.71-8.03	0.001	5.02	2.29-11	< 0.001
III	10.3	4.09-25.95	< 0.001	10.75	4.19-27.61	< 0.001
IV	10.47	4.83-22.73	< 0.001	9.81	4.47-21.51	< 0.001
Systemic therapy
No	Reference			Reference
Yes	0.3	0.22-0.42	< 0.001	0.35	0.24-0.51	< 0.001

HR: Hazard ratio; CI: Confidence interval.