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©The Author(s) 2023.
World J Gastrointest Surg. Jun 27, 2023; 15(6): 1138-1148
Published online Jun 27, 2023. doi: 10.4240/wjgs.v15.i6.1138
Published online Jun 27, 2023. doi: 10.4240/wjgs.v15.i6.1138
Overall (N = 382) | Polyps (n = 169) | Non-polyps (n = 213) | P value | |
Age, yr | 57.0 ± 14.0 | 62.1 ± 11.7 | 53.0 ± 14.4 | 0 |
19-45 | 70 (18) | 11 (7) | 59 (28) | 0 |
46-60 | 150 (39) | 65 (38) | 85 (40) | 0.428 |
61-92 | 162 (43) | 93 (55) | 69 (32) | 0 |
Male | 213 (56) | 108 (64) | 105 (49) | 0.003 |
Bilestone | 34 (9) | 18 (11) | 16 (8) | 0.187 |
Constipation | 67 (18) | 38 (22) | 29 (14) | 0.017 |
Diabetes | 53 (14) | 32 (19) | 21 (10) | 0.008 |
Fatty liver/cirrhosis | 127 (33) | 70 (41) | 57 (27) | 0.002 |
FGID | 37 (10) | 9 (5) | 28 (13) | 0.007 |
GERD | 54 (14) | 19 (11) | 35 (16) | 0.096 |
Hyperlipidemia | 60 (16) | 33 (20) | 27 (13) | 0.046 |
Hypertension | 108 (28) | 64 (38) | 44 (21) | 0 |
Hyperuricemia | 42 (11) | 20 (12) | 22 (10) | 0.38 |
IBS | 49 (13) | 14 (8) | 35 (16) | 0.013 |
PU | 31 (8) | 24 (14) | 7 (3) | 0 |
Model No. | Value cutoff (ppm) for subset | N | n (polyp/non-polyp) | Mean ppm (polyp) | Mean ppm (non-polyp) | Mean ppm | Sensitivity | Specificity | Accuracy |
1 | Methane peak value (not applied) | 382 | 169/213 | 12.82 | 12.06 | 0.074a | 0.427 | 0.578 | 0.511 |
2 | Methane peak value (≥ 5) | 359 | 160/199 | 13.34 | 12.66 | 0.084a | 0.417 | 0.571 | 0.502 |
3 | Methane peak value (≥ 10) | 245 | 120/125 | 15.28 | 15.55 | 0.905 | 0.443 | 0.390 | 0.416 |
4 | Hydrogen peak value (not applied) | 380 | 169/211 | 52.34 | 45.48 | 0.091a | 0.408 | 0.604 | 0.517 |
5 | Hydrogen peak value (≥ 10) | 310 | 140/170 | 62.05 | 55.24 | 0.090a | 0.383 | 0.590 | 0.496 |
6 | Hydrogen peak value (≥ 20) | 259 | 125/134 | 67.85 | 66.02 | 0.776 | 0.400 | 0.439 | 0.421 |
7 | Hydrogen rise value (not applied) | 372 | 165/207 | 41.94 | 37.40 | 0.121 | 0.391 | 0.582 | 0.498 |
8 | Hydrogen rise value (≥ 10) | 280 | 130/150 | 52.12 | 49.93 | 0.406 | 0.380 | 0.477 | 0.432 |
9 | Hydrogen rise value (≥ 20) | 217 | 108/109 | 60.06 | 63.39 | 0.479 | 0.492 | 0.375 | 0.433 |
10 | Hydrogen rise value (≥ 20 by 90 min) | 119 | 70/49 | 47.74 | 50.10 | 0.929 | 0.460 | 0.323 | 0.403 |
11 | Combined M peak & H peak (M ≥ 5 &/or H ≥ 10) | 373 | 166/207 | 66.15 | 58.48 | 0.068a | 0.412 | 0.615 | 0.525 |
12 | Combined M peak & H peak (M ≥ 5 & H ≥ 10) | 294 | 134/160 | 76.49 | 68.28 | 0.055a | 0.391 | 0.607 | 0.508 |
13 | Combined M peak & H risen (M ≥ 5 &/or H ≥ 10) | 370 | 166/204 | 54.58 | 50.11 | 0.166 | 0.403 | 0.578 | 0.499 |
14 | Combined M peak & H rise (M ≥ 5 & H ≥ 10) | 267 | 124/143 | 66.54 | 62.50 | 0.239 | 0.379 | 0.530 | 0.460 |
15 | Combined M peak & H peak (M ≥ 10 &/or H ≥ 20) | 177 | 96/81 | 86.28 | 85.49 | 0.674 | 0.390 | 0.395 | 0.392 |
16 | Combined M peak & H rise (M ≥ 10 & H ≥ 20) | 149 | 84/65 | 77.32 | 83.17 | 0.723 | 0.522 | 0.346 | 0.445 |
17 | Combined M peak & H rise (M ≥ 10 &/or H ≥ 20 by 90 min) | 279 | 136/143 | 42.29 | 35.71 | 0.008a | 0.382 | 0.702 | 0.546 |
Panel ID | AUC, % (95%CI) | Accuracy | Sensitivity | Specificity |
a | 71.6 (66.5-76.7) | 0.659 | 0.666 | 0.653 |
b | 71.4 (66.3-76.5) | 0.642 | 0.663 | 0.625 |
c | 72.0 (66.9-77.1) | 0.650 | 0.669 | 0.634 |
d | 71.7 (66.4-77.0) | 0.663 | 0.679 | 0.651 |
e | 72.9 (67.3-78.4) | 0.651 | 0.677 | 0.629 |
f | 72.6 (66.9-78.4) | 0.650 | 0.683 | 0.622 |
g | 71.7 (65.7-77.7) | 0.658 | 0.673 | 0.643 |
- Citation: Li L, Zhang XY, Yu JS, Zhou HM, Qin Y, Xie WR, Ding WJ, He XX. Ability of lactulose breath test results to accurately identify colorectal polyps through the measurement of small intestine bacterial overgrowth. World J Gastrointest Surg 2023; 15(6): 1138-1148
- URL: https://www.wjgnet.com/1948-9366/full/v15/i6/1138.htm
- DOI: https://dx.doi.org/10.4240/wjgs.v15.i6.1138