Diagnostic value of matrix metalloproteinases 2, 7 and 9 in urine for early detection of colorectal cancer

Table 1 Comparison of matrix metalloproteinases 2, 7, 9 and carcinoembryonic antigen contents in healthy controls, colon polyps and colorectal cancer groups

Group	Healthy control	Colon polyps	Colorectal cancer
MMP2	2128.42 (1635.60, 3119.34)	15459.62 (12244.16, 18777.56)	15396.14 (6571.35, 20006.06)
MMP7	2612.71 (2087.86, 3110.04)	3237.57 (2513.33, 3915.02)	4173.63 (3023.82, 6327.17)
MMP9	8153.00 (5170.05, 11732.83)	14288.33 (8711.57, 17994.25)	10324.22 (6005.56, 14932.17)
CEA	1.52 (0.79, 2.26)	3.05 (1.55, 7.82)	6.84 (1.86, 14.43)

MMP: Matrix metalloproteinase; CEA: Carcinoembryonic antigen.

Table 2 Diagnostic value of matrix metalloproteinases 2, 7, 9 and carcinoembryonic antigen for distinguishing healthy control group from colorectal cancer group

	AUC	Standard error	P value	95%CI
				Lower	Upper
MMP2	0.875	0.031	< 0.001	0.815	0.935
MMP7	0.786	0.039	< 0.001	0.711	0.862
MMP9	0.748	0.042	< 0.001	0.667	0.830
CEA	0.779	0.038	< 0.001	0.704	0.853

MMP: Matrix metalloproteinase; CEA: Carcinoembryonic antigen; AUC: Area under the curve; CI: Confidence interval.

Table 3 Diagnostic value of matrix metalloproteinases 2, 7, 9 and carcinoembryonic antigen for distinguishing colorectal polyp from colorectal cancer group

Indicator	AUC	Standard error	P value	95%CI
				Lower	Upper
MMP2	0.532	0.050	0.550	0.433	0.630
MMP7	0.769	0.042	< 0.001	0.688	0.851
MMP9	0.737	0.046	< 0.001	0.647	0.827
CEA	0.626	0.050	0.018	0.528	0.723

MMP: Matrix metalloproteinase; CEA: Carcinoembryonic antigen; AUC: Area under the curve; CI: Confidence interval.