Rikkunshito increases appetite by enhancing gastrointestinal and incretin hormone levels in patients who underwent pylorus-preserving pancreaticoduodenectomy: A retrospective study

doi:10.4240/wjgs.v15.i5.871

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May 27, 2023 (publication date) through Apr 24, 2024

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastrointest Surg. May 27, 2023; 15(5): 871-881
Published online May 27, 2023. doi: 10.4240/wjgs.v15.i5.871

Table 1 Clinicopathological characteristics

Variable		TJ-43(−), n = 20	TJ-43(+), n = 21	Pvalue
Age in yr		67 ± 7.0	66 ± 7.7	0.962
Sex, n (%)	Male	10 (50)	14 (67)	0.199
Sex, n (%)	Female	10 (50)	7 (33)
Disease, n (%)	Pancreas Ca. (Ph)	7 (35)	8 (38)
	IPMC	2 (10)	2 (10)
	IPMA	2 (10)	1 (5)
	CBD Ca.	5 (25)	5 (24)
	Vater Ca.	3 (15)	4 (19)
	Panaceas-NET	1 (5)	0 (0)
	GB Ca.	0 (0)	1 (5)
UICC Tumor stage: Pancreas Ca. (0/I/IIA/IIB); Other Ca. (0/I/II/III)	Pancreas Ca. (Ph)	(0/0/1/6)	(0/0/3/5)
	IPMC	(1/0/1/0)	(0/0/1/1)
	IPMA	N/A	N/A
	CBD Ca.	(0/1/4/0)	(0/3/2/0)
	Vater Ca.	(0/1/2/0)	(0/2/2/0)
	P-NET	(0/1/0/0)	N/A
	GB Ca.	N/A	(0/0/1/0)
Tumor differentiation (well/mod/poor)	Pancreas Ca. (Ph)	(3/2/2)	(1/6/1)
	IPMC	(0/2/0)	(1/0/1)
	IPMA	N/A	N/A
	CBD Ca.	(0/5/0)	(2/2/1)
	Vater Ca.	(2/1/0)	(1/3/0)
	P-NET	N/A	N/A
	GB Ca.	N/A	(0/1/0)
Time of operation in min		500 ± 56	509 ± 0.72	0.299
Blood loss in mL		692 ± 0.54	959 ± 0.66	0.182
HbA1c, %		5.6 ± 2.2	5.7 ± 2.3	0.892
Tumor markers	CEA in ng/mL	3.1 ± 1.3	3.7 ± 1.1	0.872
Tumor markers	CA19-9 in U/mL	455 ± 23	451 ± 29
DGE, %		25	19	0.773
POPF, n (%)	Grade A	15 (75)	16 (76)
POPF, n (%)	Grades B and C	5 (25)	5 (24)	0.886
Post-operative pneumonia, n (%)		1 (5)	1 (4.8)	0.889

UICC: Union for International Cancer Control; Ph: Pancreas head; IPMC: Intraductal papillary mucinous carcinoma; IPMA: Intraductal papillary mucinous adenoma; CBD: Common bile duct; Ca: carcinoma; NET: Neuroendocrine tumor; GB: Gall bladder; Hb: Hemoglobin; DGE: Delayed gastric empty; POPF: Post-operative pancreatic fistula; TJ-43: Rikkunshito; TJ-43(-): Patients without TJ-43 treatment; TJ-43(+): Patients with TJ-43 treatment; N/A: No application.

Citation: Kono H, Hosomura N, Amemiya H, Shoda K, Furuya S, Akaike H, Kawaguchi Y, Kawaida H, Ichikawa D. Rikkunshito increases appetite by enhancing gastrointestinal and incretin hormone levels in patients who underwent pylorus-preserving pancreaticoduodenectomy: A retrospective study. World J Gastrointest Surg 2023; 15(5): 871-881
URL: https://www.wjgnet.com/1948-9366/full/v15/i5/871.htm
DOI: https://dx.doi.org/10.4240/wjgs.v15.i5.871