Influence of liver function after laparoscopy-assisted vs totally laparoscopic gastrectomy

Table 1 Comparison of the general situation in each group

Variable	TLG group (n = 40)	ALG group (n = 40)	t value	P value
Age (yr)	64.63 ± 8.40	64.78 ± 9.50	0.075	0.941Nonsig
BMI (kg/m2)	22.45 ± 3.90	22.47 ± 2.89	0.020	0.984Nonsig
M/F (case)	27/13	26/14	0.056	0.813Nonsig
TG/GG (case)	13/27	19/21	1.875	0.171Nonsig

TLG: Totally laparoscopic gastrectomy; ALG: Another 7 cm longitudinal incision; BMI: Body mass index; TG: Total gastrectomy.

Table 2 Comparison of transaminase levels in each group

Variable	TLG group (n = 40)	ALG group (n = 40)	t value	P value
ALT (U/L)
BO	17.98 ± 11.44	16.28 ± 8.24	0.763	0.448Nonsig
AO
1-2 d	33.54 ± 15.28	72.49 ± 58.70	4.061	< 0.001Sig
3-4 d	19.02 ± 8.18	32.03 ± 25.27	3.099	0.003Sig
5-7 d	21.18 ± 10.13	28.90 ± 17.20	2.447	0.017Sig
AST (U/L)
BO	20.47 ± 5.88	20.56 ± 5.97	0.068	0.946Nonsig
AO
1-2 d	39.02 ± 14.67	85.27 ± 79.95	3.598	0.001Sig
3-4 d	17.99 ± 8.38	26.94 ± 19.35	2.684	0.010Sig
5-7 d	20.59 ± 8.64	26.16 ± 14.52	2.084	0.040Sig

TLG: Totally laparoscopic gastrectomy; ALG: Another 7 cm longitudinal incision; BO: Before the operation; AO: After the operation; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.

Table 3 Hierarchical comparison of transaminases in each group

Variable	TLTG group (n = 13)	LATG group (n = 19)	TLGG group (n = 27)	LAGG group (n = 21)	P value
ALT (U/L)
BO	17.50 ± 8.85	13.94 ± 6.47	18.21 ± 12.65	18.39 ± 9.21	0.1981,Nonsig, 0.9562,Nonsig
AO
1-2 d	39.60 ± 16.03	93.41 ± 77.54	30.63 ± 14.31	53.57 ± 22.72	0.0081,Sig, < 0.0012,Sig
3-4 d	20.93 ± 10.11	36.93 ± 31.96	18.10 ± 7.10	27.60 ± 16.80	0.0921,Nonsig, 0.0232,Sig
5-7 d	24.82 ± 11.65	28.99 ± 15.59	19.42 ± 9.03	28.81 ± 18.91	0.4191,Nonsig, 0.0452,Sig
AST (U/L)
BO	20.52 ± 5.96	20.13 ± 7.21	20.44 ± 5.96	20.94 ± 4.72	0.8741,Nonsig, 0.7542,Nonsig
AO
1-2 d	48.78 ± 13.56	112.37 ± 104.91	34.33 ± 12.94	60.74 ± 35.04	0.0171,Sig, 0.0032,Sig
3-4 d	20.44 ± 10.63	24.96 ± 13.41	16.81 ± 6.99	28.74 ± 23.70	0.3181,Nonsig, 0.0362,Sig
5-7 d	24.43 ± 8.54	24.49 ± 9.71	18.74 ± 8.20	27.66 ± 17.92	0.9861,Nonsig, 0.0442,Sig

¹Total laparoscopic total gastrectomy group compared with the laparoscopic-assisted total gastrectomy group;

²Total laparoscopic distal gastrectomy group compared with the laparoscopic-assisted distal gastrectomy group.

TLTG: Total laparoscopic total gastrectomy; LATG: Laparoscopic-assisted total gastrectomy; LAGG: Laparoscopic-assisted distal gastrectomy; BO: Before the operation; AO: After the operation; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.

Table 4 Comparison of bilirubin in each group

Variable	TLG group (n = 40)	ALG group (n = 40)	t value	P value
TBIL (μmol/L)
BO	13.44 ± 6.57	11.62 ± 4.85	1.409	0.163Nonsig
AO
1-2 d	15.05 ± 7.10	15.11 ± 7.27	0.042	0.967Nonsig
3-4 d	17.38 ± 8.44	11.65 ± 6.72	3.358	0.001Sig
5-7 d	15.26 ± 5.91	12.82 ± 6.70	1.728	0.088Nonsig
DBIL (μmol/L)
BO	2.40 ± 1.05	2.15 ± 0.99	1.074	0.286Nonsig
AO
1-2 d	3.74 ± 1.73	3.79 ± 2.05	0.112	0.911Nonsig
3-4 d	4.63 ± 3.32	3.22 ± 2.03	2.286	0.025Sig
5-7 d	4.17 ± 2.31	4.05 ± 4.09	0.155	0.877Nonsig
IBIL (μmol/L)
BO	10.93 ± 5.58	9.47 ± 3.93	1.355	0.179Nonsig
AO
1-2 d	11.36 ± 5.68	11.33 ± 5.45	0.020	0.984Nonsig
3-4 d	12.75 ± 5.90	8.43 ± 5.02	3.530	0.001Sig
5-7 d	11.21 ± 4.17	8.77 ± 3.54	2.819	0.006Sig

TLG: Totally laparoscopic gastrectomy; ALG: Another 7 cm longitudinal incision; TBIL: Total bilirubin; DBIL: Direct bilirubin; IBIL: Indirect bilirubin; BO: Before the operation; AO: After the operation.

Table 5 Hierarchical comparison of bilirubin in each group

Variable	TLTG group (n = 13)	LATG group (n = 19)	TLGG group (n = 27)	LAGG group (n = 21)	P value
TBIL (μmol/L)
BO	16.65 ± 9.40	11.77 ± 5.85	11.90 ± 4.04	11.49 ± 3.89	0.0801,Nonsig, 0.7262,Nonsig
AO
1-2 d	16.53 ± 7.32	15.17 ± 9.32	14.33 ± 7.01	15.06 ± 4.98	0.6621,Nonsig, 0.6872,Nonsig
3-4 d	19.62 ± 11.28	12.67 ± 8.17	16.30 ± 6.66	10.73 ± 5.11	0.0521,Nonsig, 0.0032,Sig
5-7 d	16.69 ± 6.58	13.75 ± 8.33	14.57 ± 5.56	11.98 ± 4.84	0.2951,Nonsig, 0.0972,Nonsig
DBIL (μmol/L)
BO	2.83 ± 1.42	2.12 ± 1.44	2.19 ± 0.76	2.18 ± 0.86	0.1311,Nonsig, 0.9692,Nonsig
AO
1-2 d	3.97 ± 1.67	3.69 ± 2.44	3.63 ± 1.77	3.87 ± 1.67	0.7221,Nonsig, 0.6282,Nonsig
3-4 d	4.78 ± 2.56	3.70 ± 2.46	4.56 ± 3.67	2.80 ± 1.48	0.2371,Nonsig, 0.0442,Sig
5-7 d	4.65 ± 1.51	4.63 ± 5.38	3.93 ± 2.60	3.53 ± 2.44	0.9871,Nonsig, 0.5872,Nonsig
IBIL (μmol/L)
BO	13.48 ± 8.09	9.65 ± 4.76	9.70 ± 3.42	9.30 ± 3.09	0.1021,Nonsig, 0.6782,Nonsig
AO
1-2 d	12.56 ± 5.83	11.48 ± 7.10	10.78 ± 5.62	11.20 ± 3.54	0.4541,Nonsig, 0.7652,Nonsig
3-4 d	14.83 ± 8.88	8.97 ± 6.07	11.75 ± 3.57	7.94 ± 3.94	0.0341,Sig, 0.0012,Sig
5-7 d	12.38 ± 5.33	9.12 ± 4.33	10.64 ± 3.46	8.45 ± 2.71	0.0661,Nonsig, 0.0212,Sig

¹Total laparoscopic total gastrectomy group compared with the laparoscopic-assisted total gastrectomy group;

²Total laparoscopic distal gastrectomy group compared with the laparoscopic-assisted distal gastrectomy group.

TLTG: Total laparoscopic total gastrectomy; LATG: Laparoscopic-assisted total gastrectomy; TLGG: Total laparoscopic distal gastrectomy; LAGG: Laparoscopic-assisted distal gastrectomy; TBIL: Total bilirubin; DBIL: Direct bilirubin; IBIL: Indirect bilirubin; BO: Before the operation; AO: After the operation.

Table 6 Comparison of other liver function indicators in each group

Variable	TLG group (n = 40)	ALG group (n = 40)	t value	P value
ALP (U/L)
BO	78.78 ± 16.73	76.10 ± 20.28	0.644	0.521Nonsig
AO
1-2 d	60.59 ± 14.26	59.86 ± 13.99	0.231	0.818Nonsig
3-4 d	65.40 ± 15.58	57.06 ± 13.76	2.539	0.013Sig
5-7 d	73.97 ± 17.62	64.77 ± 26.06	1.850	0.068Nonsig
GGLT (U/L)
BO	28.06 ± 32.63	31.70 ± 28.05	0.536	0.593Nonsig
AO
1-2 d	20.46 ± 25.74	34.07 ± 26.10	2.347	0.021Sig
3-4 d	28.47 ± 29.22	24.11 ± 16.19	0.825	0.413Nonsig
5-7 d	50.66 ± 37.38	54.33 ± 39.28	0.428	0.670Nonsig

TLG: Totally laparoscopic gastrectomy; ALG: Another 7 cm longitudinal incision; GGLT: γ-glutamyltransferase; ALP: Alkaline phosphatase; BO: Before the operation; AO: After the operation.

Table 7 Hierarchical comparison of the other liver function indicators in each group

Variable	TLTG group (n = 13)	LATG group (n = 19)	TLGG group (n = 27)	LAGG group (n = 21)	P value
ALP (U/L)
BO	83.63 ± 13.24	76.36 ± 25.15	76.44 ± 17.92	75.87 ± 15.27	0.3481,Nonsig, 0.9072,Nonsig
AO
1-2 d	59.95 ± 9.59	57.47 ± 15.06	60.89 ± 16.19	62.01 ± 12.93	0.6041,Nonsig, 0.7962,Nonsig
3-4 d	68.39 ± 15.53	56.44 ± 15.68	63.96 ± 15.70	57.61 ± 12.12	0.0421,Sig, 0.1332,Nonsig
5-7 d	83.56 ± 19.69	66.68 ± 31.49	69.35 ± 14.78	63.04 ± 20.63	0.0971,Nonsig, 0.2232,Nonsig
GGLT (U/L)
BO	27.42 ± 30.31	33.03 ± 32.33	28.36 ± 34.25	30.50 ± 24.29	0.6251,Nonsig, 0.8092,Nonsig
AO
1-2 d	19.15 ± 19.42	37.11 ± 28.46	21.09 ± 28.61	31.32 ± 24.15	0.0421,Sig, 0.1962,Nonsig
3-4 d	34.22 ± 36.82	26.34 ± 19.69	25.70 ± 25.12	22.10 ± 12.39	0.4901,Nonsig, 0.5002,Nonsig
5-7 d	59.74 ± 34.97	56.77 ± 44.02	46.29 ± 38.34	52.13 ± 35.42	0.8401,Nonsig, 0.5922,Nonsig

¹Total laparoscopic total gastrectomy group compared with the laparoscopic-assisted total gastrectomy group;

²Total laparoscopic distal gastrectomy group compared with the laparoscopic-assisted distal gastrectomy group.

TLTG: Total laparoscopic total gastrectomy; LATG: Laparoscopic-assisted total gastrectomy; TLGG: Total laparoscopic distal gastrectomy; LAGG: Laparoscopic-assisted distal gastrectomy; TLG: Totally laparoscopic gastrectomy; ALG: Another 7 cm longitudinal incision; GGLT: γ-glutamyltransferase; ALP: Alkaline phosphatase; BO: Before the operation; AO: After the operation.