Surgical treatment for recurrent hepatocellular carcinoma: Current status and challenges

Table 1 Statistics showing survival after surgical treatment of recurrent liver cancer based on published studies spanning 1989 to 2017

Ref.	Study design	Study period	n	Treatment	DFS rate (1-, 3-, 5-yr)	OS rate (1-, 3-, 5-yr)	DSS rate (1-, 3-, 5-yr)
Guerrini et al[84], 2014	Retrospectivecohort	2000-2011	28	SLT	95.1%, 80.6%, 80.6%	85.1%, 66,4%, 49.2%	NA
Qu et al[75], 2015	Retrospectivecohort	2000-2011	111	SLT	NA	75.5%, 56.3%, 49.1%	NA
Yamashita et al[62], 2015	Retrospectivecohort	1989–2012	13	SLT	NA, NA, 81%	NA, NA, 75%	NA
Lim et al[81], 2017	Retrospectivecohort	1994-2011	17	SLT	NA, 80%, 72%	NA, 71%, 71%	NA
Chan et al[3], 2019	Retrospectivecohort	2005-2017	59	SLT	84.8%, 68.2%, 68.2%	NA	95.7%, 74.4%, 66.7%
Yoon et al[85], 2022	Retrospectivecohort	2005-2017	42	SLT	91.6%, 78.6%, 76.8%	NA	98.8%, 90.7%, 87.0%
Minagawa et al[47], 2003	Retrospectivecohort	1994-2000	67	RLR	50%, 21%, 17%	93%, 70%, 56%	NA
Itamoto et al[38], 2007	Retrospectivecohort	1990-2004	84	RLR	56%, 25%, 10%	88%, 67%, 50%	NA
Wu et al[41], 2009	Retrospectivecohort	1990-2007	149	RLR	NA, NA, 31.8%	NA, NA, 56.4%	NA
Faber et al[86], 2011	Retrospectivecohort	1990-2009	27	RLR	NA	96%, 70%, 42%	NA
Yamashita et al[62], 2015	Retrospectivecohort	1989-2012	146	RLR	NA, NA, 16%	NA, NA, 61%	NA
Lim et al[81], 2017	Retrospectivecohort	1994-2011	80	RLR	NA, 22%, 18%	NA, 82%, 71%	NA

DFS: Disease-free survival; OS: Overall survival; DSS: Disease-specific survival; SLT: Salvage liver transplantation; RLR: Repeated liver resection; NA: Not available.