Differential expression and significance of 5-hydroxymethylcytosine modification in hepatitis B virus carriers and patients with liver cirrhosis and liver cancer

Table 1 Differential genes between hepatitis B surface antigen-positive carriers and patients with liver cancer after 5-hydroxymethylcytosine sequencing

Symbol	Ensembl	log2FoldChange	padj
SI	ENSG00000090402	0.849003917	0.000172596
FAM83B	ENSG00000168143	0.532487323	0.00425853
PCK1	ENSG00000124253	0.519299173	0.006848676
KCNN2	ENSG00000080709	-0.510730422	0.011078186
FAT1	ENSG00000083857	0.47499449	0.02542581
FGF19	ENSG00000162344	0.428605733	0.036854977
FABP1	ENSG00000163586	0.427372957	0.025268146
SLC10A2	ENSG00000125255	0.417559665	0.005504835
ISX	ENSG00000175329	0.391889896	0.005936182
APOC3	ENSG00000110245	0.374978715	0.017711634
NOVA1	ENSG00000139910	0.367147827	0.006848676
KRT20	ENSG00000171431	0.361001798	0.049694505
DUSP1	ENSG00000120129	0.341097702	0.001523335
RBP2	ENSG00000114113	0.330491105	0.049694505
PCLO	ENSG00000186472	0.307272826	0.000520372
BRINP3	ENSG00000162670	0.297534011	0.001107995
SLC2A2	ENSG00000163581	0.297032232	0.006630228
AKR1B10	ENSG00000198074	0.296134756	0.012660193
SEMA3A	ENSG00000075213	0.295498456	7.92E-05
SLC5A1	ENSG00000100170	0.295343232	0.027331533
ROBO1	ENSG00000169855	0.294408057	0.026805139
ROPN1B	ENSG00000114547	-0.292505301	0.002291301
PRR16	ENSG00000184838	0.291799543	0.049694505
TNFSF15	ENSG00000181634	0.286998557	0.01533013
CDH17	ENSG00000079112	0.284940571	0.001204498
MUC17	ENSG00000169876	0.284637524	0.022168549
PCDH7	ENSG00000169851	0.284173648	0.00131498
FOS	ENSG00000170345	0.28075648	0.008754834
GABRA2	ENSG00000151834	0.27973066	0.049694505
NRCAM	ENSG00000091129	0.270536808	0.047702973
DPP10	ENSG00000175497	0.268657512	0.005504835

Table 2 Differential genes between patients with liver cirrhosis and those with liver cancer after 5-hydroxymethylcytosine sequencing

Symbol	Ensembl	log2FoldChange	padj
MUC8	NA	-0.61023	0.048721
PROX1	ENSG00000117707	0.510971	0.047662
TBX3	ENSG00000135111	0.380857	0.04644
DSC2	ENSG00000134755	0.366222	0.021397
PSME1	ENSG00000092010	0.340336	0.036054
C2orf72	ENSG00000204128	0.339959	0.015473
PTP4A1	ENSG00000112245	0.33768	0.043273
KCTD12	E0NSG00000178695	0.325745	0.016818
FMO2	ENSG00000094963	0.320229	0.040782
LGALS9C	ENSG00000171916	-0.29776	0.040782
CYP3A5	ENSG00000106258	0.292488	0.048557
SNAPC5	ENSG00000174446	0.290892	0.020989
TMEM176A	ENSG00000002933	0.285556	0.04535
SMPDL3A	ENSG00000172594	0.283335	0.036054
TNFSF10	ENSG00000121858	0.281624	0.009552
CYP27A1	ENSG00000135929	0.275649	0.038131
FAM20A	ENSG00000108950	0.275255	0.040338
CCDC67	NA	0.268828	0.036054
IL37	ENSG00000125571	-0.26789	0.021397
RBM47	ENSG00000163694	0.267243	0.038605