Chen JL, Chen YS, Ker CG. Network meta-analysis of the prognosis of curative treatment strategies for recurrent hepatocellular carcinoma after hepatectomy. World J Gastrointest Surg 2023; 15(2): 258-272 [PMID: 36896302 DOI: 10.4240/wjgs.v15.i2.258]
Corresponding Author of This Article
Chen-Guo Ker, FACS, MD, PhD, Professor, Department of General Surgery, E-Da Hospital, I-Shou University, Yi-Da Road, Jian-Su Village, Yan-Chio District, Kaohsiung 824, Taiwan. ed112739@edah.org.tw
Research Domain of This Article
Surgery
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
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World J Gastrointest Surg. Feb 27, 2023; 15(2): 258-272 Published online Feb 27, 2023. doi: 10.4240/wjgs.v15.i2.258
Table 1 Cumulative mean value of 49 arms of studies and patient profiles from 30 articles of curative treatment of recurrent hepatocellular carcinoma after primary liver resection
Table 4 Overall heterogeneity of outcome measured by Q test with random effects model and pooled effect size of each subgroup
Outcome
Heterogeneity
Pooled effect (overall)
Q value
df (Q)
P value
I2
Z value
95%CI
P value
1-yr DFS
224.670
30
< 0.001
86.65
0.672
0.625-0.716
P < 0.001
3-yr DFS
583.665
30
< 0.001
94.86
0.414
0.370-0.46
P < 0.001
5-yr DFS
764.476
32
< 0.001
95.81
0.315
0.276-0.357
P < 0.001
1-yr OS
219.820
46
< 0.001
79.07
0.874
0.850-0.895
P < 0.001
3-yr OS
437.662
45
0.002
89.72
0.642
0.642-0.714
P < 0.001
5-yr OS
730.285
48
< 0.001
93.43
0.546
0.497-0.594
P = 0.068
Table 5 Summary of the better pooled outcome of treatments depended on the analysis method
Test method
1-yr DFS
3-yr DFS
5-yr DFS
1-yr OS
3-yr OS
5-yr OS
Wilcoxon rank sum test
LT
LT
LT
RFA
RH
RH
Forest plot analysis
LT
LT
LT
LT
RH
RH
Wald test
LT
LT
LT
LT
RH
RH
P score
LT
LT
LT
RH
RH
RH
Meta-regression analysis
LT
LT
LT
RH
LT
LT
Citation: Chen JL, Chen YS, Ker CG. Network meta-analysis of the prognosis of curative treatment strategies for recurrent hepatocellular carcinoma after hepatectomy. World J Gastrointest Surg 2023; 15(2): 258-272