Analysis of nutritional risk, skeletal muscle depletion, and lipid metabolism phenotype in acute radiation enteritis

Table 1 Grading of adverse reactions in radiation-induced acute intestinal symptoms

Adverse reaction	Level 0	Level 1	Level 2	Level 3
Diarrhea	13 (26)	29 (58)	5 (10)	3 (6)
Abdominal pain	29 (58)	18 (36)	3 (6)	0 (0)
Colitis	38 (76)	12 (24)	0 (0)	0 (0)
Anal swelling	33 (66)	11 (22)	6 (12)	0 (0)
Hematochezia	35 (70)	15 (30)	0 (0)	0 (0)
Myelosuppression	15 (30)	13 (26)	12 (24)	10 (20)

Data are n (50).

Table 2 Univariate analysis of the influence of skeletal muscle exhaustion in patients with cervical cancer during the periradiation therapy

Project	B	SE	Exp (B)	95%CI		Wald χ2	P value
				Lower limit	Upper limit
Time of radiotherapy
T2	Reference
T4	0.405	0.381	1.013	1.001	1.518	1.834	0.042
Tf	1.023	0.538	1.023	1.004	1.238	17.394	0.015
Weight	0.294	0.345	0.925	0.681	3.019	2.736	0.045
Percentage reduction of serum albumin	1.281	0.326	3.602	1.902	6.823	15.461	< 0.001
Percentage reduction of serum prealbumin	0.892	0.411	2.491	1.138	2.831	12.028	< 0.001
Tumor staging
I–II	Reference
III–IV	1.029	0.024	3.092	0.001	3.861	0.492	0.689
BMI	0.836	0.277	1.029	0.308	3.892	0.108	0.588
Body fat content	0.424	0.011	1.281	0.891	1.782	0.347	0.052

CI: Confidence interval; BMI: Body mass index; SE: Standard error; T2: The 2^nd week after the start of radiotherapy; T4: The 4^th week after the start of radiotherapy; Tf: The end of radiotherapy.

Table 3 Multivariate analysis of the changes of linoleic acid content in the fecal supernatant of patients with cervical cancer during the periradiation period

Project	B	SE	Exp (B)	95%CI		Wald χ2	P value
				Lower limit	Upper limit
Time of radiotherapy
T2	Reference
T4	0.701	0.402	1.194	1.042	1.598	3.928	0.038
Tf	1.638	0.618	1.284	1.403	1.902	5.392	0.019
Percentage of skeletal muscle exhaustion	0.361	0.203	1.021	1.081	2.214	7.027	0.011
NRS 2002 score	1.029	0.682	1.104	1.002	2.482	12.382	< 0.001
Percentage reduction of serum albumin	0.792	0.134	1.294	0.293	2.521	0.782	0.363
Percentage reduction of serum prealbumin	1.385	0.382	0.821	0.564	1.905	0.556	0.892
Phase angle	0.729	0.103	0.892	0.361	1.028	0.992	0.059

95%CI: 95% confidence interval; NRS: Nutritional risk screening; SE: Standard error; T2: The 2^nd week after the start of radiotherapy; T4: The 4^th week after the start of radiotherapy; Tf: The end of radiotherapy.