Correlation between the expressions of metastasis-associated factor-1 in colon cancer and vacuolar ATP synthase

Table 1 Comparison of metastasis-associated factor-1 and vacuolar ATP synthase expression in colon cancer and paracancerous tissues

Group	Cases	MACC1 positive expression (%)	V-ATPase positive expression (%)
Colon cancer	104	67 (64.42)	70 (67.31)
Paracancerous tissue	104	20 (19.23)	8 (7.69)
χ2		43.647	78.851
P value		0.000	0.000

MACC1: Metastasis-associated factor-1; V-ATPase: Vacuolar ATP synthase.

Table 2 The relationship between the expression of metastasis-associated factor-1, vacuolar ATP synthase and clinicopathological features of colon cancer

Clinicopathologcal features	Cases	MACC1 positive expression (%)	χ2	P value	V-ATPase positive expression (%)	χ2	P value
Age (years)
≤ 55 years old	54	33 (61.11)	0.538	0.463	35 (64.81)	0.317	0.573
> 55 years old	50	34 (68.00)			35 (70.00)
Gender
Male	56	35 (62.50)	0.196	0.658	40 (71.43)	0.936	0.333
Female	48	32 (66.67)			30 (62.50)
Tumor site
Left colon	50	32 (64.00)	0.008	0.931	36 (72.00)	0.964	0.326
Right colon	54	35 (64.81)			34 (62.96)
TNM staging
Phase Ⅰ-Ⅱ	65	34 (52.31)	11.101	0.001	35 (53.85)	14.275	0.000
Phase Ⅲ	39	33 (84.62)			35 (89.74)
Degree of differentiation
High differentiation	31	12 (38.71)	12.74	0.000	11 (35.48)	20.327	0.000
Medium and low differentiation	73	55 (75.34)			59 (80.82)
Lymph node metastasis
Yes	49	40 (81.63)	11.973	0.001	42 (85.71)	14.266	0.000
No	55	27 (49.09)			28 (50.91)
Vascular infiltration
Yes	41	24 (58.54)	1.023	0.312	26 (63.41)	0.466	0.496
No	63	43 (68.25)			44 (69.84)
Nervous system infiltration
Yes	32	22 (68.75)	0.378	0.539	21 (65.63)	0.059	0.807
No	72	45 (62.50)			49 (68.06)
Tumor diameter
> 5 cm	60	46 (76.67)	9.276	0.002	40 (66.67)	0.026	0.871
≤ 5 cm	44	21 (47.73)			30 (68.18)

MACC1: Metastasis-associated factor-1; V-ATPase: Vacuolar ATP synthase.

Table 3 Correlation analysis

MACC1 expression	V-ATPase expression		rs	P value
	Positive	Negative
Positive	63	4	0.797	0.000
Negative	7	30

MACC1: Metastasis-associated factor-1; V-ATPase: Vacuolar ATP synthase.

Table 4 Comparison of the expression of metastasis-associated factor-1 and vacuolar ATP synthase in colon cancer tissues between patients with postoperative recurrence and patients without postoperative recurrence

Group	Cases	MACC1 positive expression (%)	V-ATPase positive expression (%)
Recurrence	72	52 (72.22)	57 (79.17)
No recurrence	32	15 (46.88)	13 (40.63)

MACC1: Metastasis-associated factor-1; V-ATPase: Vacuolar ATP synthase.

Table 5 Results of logistic regression analysis

Factor	β	SE	Walds	P value	OR (95%CI)
TNM staging	1.844	0.411	20.130	0.000	6.322 (2.825-14.148)
Lymph node metastasis	1.234	0.315	15.346	0.000	3.435 (1.853-6.369)
MACC1 expression	0.987	0.264	13.977	0.000	2.683 (1.599-4.502)
V-ATPase expression	0.884	0.221	16.000	0.000	2.421 (1.570-3.733)

MACC1: Metastasis-associated factor-1; V-ATPase: Vacuolar ATP synthase.