Correlation between preoperative systemic immune inflammation index, nutritional risk index, and prognosis of radical resection of liver cancer

Table 1 Area under the curve of preoperative systemic immune inflammatory index and geriatric nutritional risk index in predicting death in patients undergoing radical resection of liver cancer

Test result variables	AUC	SE	P value	95%CI
				Lower limit	Upper limit
SII	0.728	0.065	0.0011	0.600	0.856
GNRI	0.227	0.056	< 0.0012	0.117	0.337
SII + GNRI	0.817	0.052	< 0.0013	0.715	0.919

¹P < 0.05 vs null hypothesis.

²P < 0.05 vs null hypothesis.

³P < 0.05 vs null hypothesis.

AUC: Area under the curve; 95%CI: 95% confidence interval; GNRI: Geriatric nutritional risk index; SII: Systemic immune inflammatory index.

Table 2 Relationship between preoperative systemic immune inflammatory index and clinicopathological features of patients undergoing radical resection of liver cancer

Indexes	Number of cases	SII		χ2	P value
		> 309.14 (47 cases)	≤ 309.14 (53 cases)
Gender				0.002	0.965
Male	70	33 (70.21)	37 (69.81)
Female	30	14 (29.79)	16 (30.19)
Age				0.047	0.828
≤ 70 yr old	33	15 (31.91)	18 (33.96)
> 70 yr old	67	32 (68.09)	35 (66.04)
Hepatitis B markers				0.097	0.755
Negative	27	12 (25.53)	15 (28.30)
Positive	73	35 (74.47)	38 (71.70)
Degree of differentiation				4.643	0.031
Middle-low differentiation	55	20 (42.55)	35 (66.04)
High differentiation	45	27 (57.45)	18 (33.96)
Maximum tumor diameter				6.807	0.033
5 cm	28	8 (17.02)	20 (37.74)
5-10 cm	54	27 (57.45)	27 (50.94)
> 10 cm	18	12 (25.53)	6 (11.32)
Number of tumors				0.004	0.948
3	13	6 (12.77)	7 (13.21)
≥ 3	87	41 (87.23)	46 (86.79)
Ascites				0.846	0.358
No	79	39 (82.98)	40 (75.47)
Yes	21	8 (17.02)	13 (24.53)
Lymph node metastasis				8.687	0.003
Yes	38	21 (44.68)	17 (32.08)
No	62	26 (55.32)	36 (67.92)
TNM staging				7.517	0.006
I–II	59	21 (44.68)	38 (71.70)
III–IV	41	26 (55.32)	15 (28.30)
Envelope Integrity				0.525	0.469
Complete	57	25 (53.19)	32 (60.38)
Incomplete	43	22 (46.81)	21 (39.62)
Portal vein tumor thrombus				0.200	0.655
Yes	32	14 (29.79)	18 (33.96)
No	68	33 (70.21)	35 (66.04)
Child-Pugh classification				0.424	0.515
A	54	27 (57.45)	27 (50.94)
B	46	20 (42.55)	26 (49.06)
Alpha-fetoprotein expression				0.102	0.749
Negative	43	21 (44.68)	22 (41.51)
Positive	57	26 (55.32)	31 (58.49)

SII: Systemic immune inflammatory index; TNM: tumor node metastasis.

Table 3 Relationship between preoperative geriatric nutritional risk index and clinicopathological features of patients undergoing radical resection of liver cancer

Indexes	Number of cases	GNRI		χ2	P value
		≤ 98 (20 cases)	> 98 (80cases)
Gender				0.298	0.585
Male	70	15 (75.00)	55 (68.75)
Female	30	5 (25.00)	25 (31.25)
Age				4.752	0.029
≤ 70 yr old	33	2 (10.00)	31 (38.75)
> 70 yr old	67	18 (90.00)	49 (61.25)
Hepatitis B markers				0.257	0.612
Negative	27	4 (20.00)	23 (28.75)
Positive	73	16 (80.00)	57 (71.25)
Degree of differentiation				< 0.001	> 0.999
Middle-low differentiation	55	11 (55.00)	44 (55.00)
High differentiation	45	9 (45.00)	36 (45.00)
Maximum tumor diameter				0.141	0.932
< 5 cm	28	5 (25.00)	23 (28.75)
5-10 cm	54	11 (55.00)	43 (53.75)
> 10 cm	18	4 (20.00)	14 (17.50)
Number of tumors				0.174	0.677
< 3	10	3 (15.00)	7 (8.75)
≥ 3	90	17 (85.00)	73 (91.25)
Ascites				1.221	0.269
No	79	14 (70.00)	65 (81.25)
Yes	21	6 (30.00)	15 (18.75)
Lymph node metastasis				0.042	0.837
Yes	38	8 (40.00)	30 (37.50)
No	62	12 (60.00)	50 (62.50)
TNM staging				0.056	0.812
I–II	77	15 (75.00)	62 (77.50)
III–IV	23	5 (25.00)	18 (22.50)
Envelope Integrity				0.092	0.762
Complete	57	12 (60.00)	45 (56.25)
Incomplete	43	8 (40.00)	35 (43.75)
Portal vein tumor thrombus				0.103	0.748
Yes	32	7 (35.00)	25 (31.25)
No	68	13 (65.00)	55 (68.75)
Child-Pugh classification				< 0.001	> 0.999
A	60	12 (60.00)	48 (60.00)
B	40	8 (40.00)	32 (40.00)
Alpha-fetoprotein expression				0.092	0.762
Negative	43	8 (40.00)	35 (43.75)
Positive	57	12 (60.00)	45 (56.25)

GNRI: Geriatric nutritional risk index; SII: Systemic immune inflammatory index.

Table 4 Kaplan-Meier survival curve

Indicators	Number of follow-up cases	1-year survival (rate, %)	Log-rank test
			χ2	P value
SII			17.706	< 0.001
> 309.14	47	19 (40.43)
≤ 309.14	53	5 (9.43)
GNRI			21.624	< 0.001
> 98	80	12 (15.00)
≤ 98	20	12 (60.00)

GNRI: Geriatric nutritional risk index; SII: Systemic immune inflammatory index.

Table 5 Cox multivariate analysis of 1-year prognosis in patients undergoing radical resection of liver cancer

Variable	B	SE	Wald	P value	RR	95%CI
						Lower limit	Upper limit
SII	2.345	0.639	13.445	< 0.001	10.429	2.978	36.518
GNRI	1.490	0.532	7.833	0.005	4.438	1.563	12.602
Gender	0.600	0.528	1.291	0.256	1.822	0.647	5.131
Age	0.041	0.025	2.760	0.097	1.042	0.993	1.093
Hepatitis B markers	-0.339	0.527	0.414	0.520	0.713	0.254	2.000
Degree of differentiation	0.072	0.619	0.014	0.907	1.075	0.320	3.617
Maximum tumor diameter	-0.056	0.053	1.091	0.296	0.946	0.852	1.050
Number of tumors	-0.148	0.082	3.275	0.070	0.863	0.735	1.012
Ascites	-0.020	0.554	0.001	0.971	0.980	0.331	2.902
Lymph node metastasis	0.226	0.495	0.209	0.647	1.254	0.475	3.309
TNM staging	-0.478	0.568	0.709	0.400	0.620	0.204	1.886
Envelope Integrity	-0.456	0.493	0.853	0.356	0.634	0.241	1.668
Portal vein tumour thrombus	0.581	0.479	1.470	0.225	1.788	0.699	4.575
Child-Pugh classification	0.321	0.467	0.472	0.492	1.378	0.552	3.440
Alpha-fetoprotein expression	0.095	0.504	0.036	0.851	1.100	0.409	2.955

95%CI: 95% confidence interval; B: Regression coefficient β; GNRI: Geriatric nutritional risk index; RR: Relative ratio; SII: Systemic immune inflammatory index; TNM: Tumor node metastasis.