Effect of low anterior resection syndrome on quality of life in colorectal cancer patients: A retrospective observational study

doi:10.4240/wjgs.v15.i10.2123

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastrointest Surg. Oct 27, 2023; 15(10): 2123-2132
Published online Oct 27, 2023. doi: 10.4240/wjgs.v15.i10.2123

Table 1 Association between low anterior resection syndrome symptoms and patient quality of life

	No LARS (n = 51)	LARS (n = 171)	P value
Physical function: High/low	36 (70.6%)/15 (29.4%)	87 (50.6%)/85 (49.4%)	0.008¹
Role function: High/low	33 (64.7%)/18 (35.3%)	88 (51.5%)/84 (48.5%)	0.06
Emotional function: High/low	38 (74.5%)/13 (25.5%)	98 (56.9%)/74 (43.1%0	0.017²
Cognitive function: High/low	36 (70.6%)/15 (29.4%)	75 (43.8%)/97 (56.2%)	0.001¹
Total health status: High/low	29 (56.9%)/22 (43.1%)	69 (40.3%)/103 (59.7%)	0.026²
Fatigue: High/low	33 (64.7%)/18 (35.3%)	86 (50%)/86 (50%)	0.045²
Nausea and vomiting: High/low	45 (88.2%)/6 (11.8%)	146 (84.9%)/26 (15.1%)	0.365
Pain: High/low	44 (86.3%)/7 (13.7%)	109 (63.4%)/63 (36.6%)	0.001¹
Polypnea: High/low	46 (90.2%)/5 (9.8%)	129 (75.0%)/43 (25%)	0.013²
Sleeplessness: High/low	40 (78.4%)/11 (21.6%)	93 (54.1%)/79 (45.9%)	0.001¹
Appetite loss: High/low	42 (82.3%)/9 (17.6%)	126 (73.3%)/46 (26.7%)	0.126
Constipation: High/low	35 (68.6%)/16 (31.4%)	71 (41.3%)/101 (58.7%)	0.001¹
Diarrhea: High/low	41 (80.4%)/10 (19.6%)	77 (44.8%)/95 (57.2%)	0.001¹
Financial difficulty: High/low	46 (90.2%)/5 (9.8%)	142 (82.5%)/30 (17.5%)	0.135

¹P ≤ 0.001.

²P ≤ 0.05, statistically significant.

LARS: Low anterior resection syndrome.

Table 2 Association between low anterior resection syndrome symptoms and quality of life in patients with colorectal cancer

	Without LARS (n = 51)	With LARS (n = 171)	P value
Frequent micturition: With/without	27 (52.3%)/24 (47.9%)	74 (43.0%)/98 (56.9%)	0.138
Blood in stool: With/without	41 (80/4%)/10 (19.6%)	106 (61.6%)/66 (38.4%)	0.009¹
Body image: With/without	41 (80/4%)/10 (19.6%)	88 (51.2%)/84 (48.8%)	0.001¹
Male sexual function: With/without	16 (44.4%)/20 (55.6%)	60 (53.6%)/52 (46.4%)	0.223
Impotence: With/without	21 (61.7%)/13 (38.3%)	52 (50%)/52 (50%)	0.160
Female sexual function: With/without	9 (81.8%)/2 (18.2%)	37 (80.4%)/9 (19.6%)	0.644
Pain: With/without	8 (88.8%)/1 (11.1%)	33 (78.6%)/9 (21.4%)	0.429
Uroclepsia: With/without	49 (96.1%)/2 (3.9%)	149 (86.6%)/23 (13.3%)	0.061
Odynuria: With/without	47 (92.1%)/4 (7.8%)	157 (91.3%)/15 (8.7%)	0.816
Stomachache: With/without	44 (86.3%)/7 (13.7%)	129 (75.0%)/43 (25.0%)	0.062
Pygalgia: With/without	48 (94.1%)/3 (5.9%)	128 (74.4%)/44 (25.6%)	0.001¹
Ventosity: With/without	44 (86.3%)/7 (13.7%)	110 (63.9%)/62 (36.1%)	0.001¹
Thirst: With/without	32 (19.6%)/19 (37.2%)	83 (48.3%)/89 (51.2%)	0.048¹
Alopecia: With/without	47 (92.2%)/4 (7.8%)	118 (68.6%)/54 (31.4%)	0.001¹
Allotriogeustia: With/without	46 (90.2%)/5 (9.8%)	114 (66.3%)/28 (33.8%)	0.180
Anxiety: With/without	29 (56.9%)/22 (43.1%)	54 (31.3%)/118 (68.6%)	0.001¹
Obesity: With/without	35 (68.6%)/16 (31.3%)	97 (56.4%)/75 (43.6%)	0.08¹

¹P ≤ 0.001, statistically significant difference.

LARS: Low anterior resection syndrome.

Table 3 Low anterior resection syndrome is correlated with clinicopathological features of colorectal cancer patients

	Low LARS score (n = 99)	High LARS score (n = 124)	P value
Age (yr): < 59/≥ 60	49 (49.5%)/50 (50.5%)	62 (50.0%)/62 (50.0%)	0.524
Sex: Male/female	73 (73.4%)/26 (26.3%)	81 (65.3%)/43 (34.6%)	0.114
Tumor size (cm): < 4/≥ 4	44 (44.4%)/52 (55.6%)	69 (55.6%)/49 (44.4%)	0.044
Length (cm): < 12/≥ 12	25 (25.3%)/63 (74.7%)	25 (23.1%)/83 (76.8%)	0.249
Length of distal margin (cm): < 3/≥ 3	43 (52.4%)/39 (47.6%)	52 (57.1%)/39 (42.8%)	0.32
T: 0, 1/2, 3	10 (15.1%)/56 (84.8%)	13 (17.6%)61 (82.4%)	0.439
N: < 17/≥ 17	60 (61.8%)/37 (38.1%)	77 (63.1%)/45 (36.9%0	0.479
M: No/yes	86 (92.5%)/7 (7.5%)	86 (89.6%)/10 (10.4%)	0.331
Differentiated degree: 0, 1/2, 3	31 (31.9%)/66 (68.1%0	45 (37.8%)/74 (62.2%)	0.264
TME/PME	59 (62.1%)/39 (37.9%)	58 (47.5%)/64 (52.4%)	0.041
Anal distance: < 9/≥ 9(cm)	41 (41.8%)/57 (58.2%)	62 (51%)/60 (49%)	0.117
Fistulation: No/yes	53 (53.5%)/46 (46.5%)	50 (41.3%)/71 (58.7%)	0.005
Preoperation radiotherapy: No/yes	79 (81.4%)/18 (18.6%)	79 (64.7%)/43 (35.1%)	0.021¹
Neoadjuvant chemotherapy: No/yes	84 (85.7%)/14 (24.3%)	84 (68.3%)/39 (31.7%)	0.007²

¹P ≤ 0.05.

²P ≤ 0.001, statistically significant difference.

T: Tumor; N: Node; M: Metastasis; TME/PME: Total/partial mesorectal excision.

Citation: Jin DA, Gu FP, Meng TL, Zhang XX. Effect of low anterior resection syndrome on quality of life in colorectal cancer patients: A retrospective observational study. World J Gastrointest Surg 2023; 15(10): 2123-2132
URL: https://www.wjgnet.com/1948-9366/full/v15/i10/2123.htm
DOI: https://dx.doi.org/10.4240/wjgs.v15.i10.2123