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©The Author(s) 2022.
World J Gastrointest Surg. Aug 27, 2022; 14(8): 833-848
Published online Aug 27, 2022. doi: 10.4240/wjgs.v14.i8.833
Published online Aug 27, 2022. doi: 10.4240/wjgs.v14.i8.833
Table 1 General clinical characteristics of study subjects
Clinical features | Model building | Model validation | ||
CRC (n = 101) | CRP (n = 59) | CRC (n = 62) | CRP (n = 30) | |
Age | ||||
Average | 58 | 56 | 57 | 57 |
Range | 29-81 | 31-76 | 33-74 | 35-69 |
Sex | ||||
Male | 60 | 34 | 37 | 19 |
Female | 41 | 25 | 25 | 11 |
Location | ||||
Ascending colon | 21 | 17 | ||
Descending colon | 15 | 12 | ||
Transverse colon | 3 | 4 | ||
Sigmoid colon | 59 | 28 | ||
Rectal | 3 | 1 | ||
Differentiation | ||||
Well | 21 | 15 | ||
Moderate | 57 | 33 | ||
Poorly | 23 | 14 | ||
TNM stage | ||||
T1 | 11 | 11 | ||
T2 | 27 | 21 | ||
T3 | 44 | 7 | ||
T4 | 19 | 23 |
Table 2 Comparison of 51 common clinical indicators between colon polyp group and colorectal cancer group
Index | CRP (n = 59) | CRC (n = 101) | F value | Sig | P value |
CEA | 1.86 (1.17, 2.43) | 3.9 (1.67, 13.87) | 11.39 | < 0.01 | < 0.01 |
AFP | 2.58 (1.87, 3.59) | 2.41 (1.75, 3.36) | 0.02 | 0.90 | 0.41 |
CA125 | 9.78 (6.77, 13.55) | 11.63 (7.98, 19.9) | 4.80 | 0.03 | 0.04 |
CA199 | 8.57 (5.44, 14.38) | 13.43 (7.22, 26.48) | 3.62 | 0.06 | 0.22 |
CA153 | 9.5 (7.08, 13.09) | 9.25 (6.6, 13) | 1.53 | 0.22 | 0.49 |
CA724 | 1.63 (1.16, 4.39) | 2.55 (1.36, 7.33) | 5.54 | 0.02 | 0.07 |
CY211 | 1.82 (1.4, 2.89) | 2.3 (1.63, 3.58) | 9.29 | < 0.01 | < 0.01 |
Ferr | 150.9 (85.62, 269.5) | 72.12 (17.02, 161.5) | 0.11 | 0.74 | 0.01 |
NSE | 8.06 (6.52, 9.16) | 10 (7.71, 12.63) | 4.58 | 0.03 | < 0.01 |
SCC | 1.1 (0.7, 1.5) | 0.8 (0.6, 1.2) | 2.96 | 0.09 | 0.19 |
PG I/II | 4.576 (2.835, 5.914) | 5.12 (3.7, 6.53) | 0.10 | 0.76 | 0.08 |
PG II | 15.9 (9, 28.3) | 14.6 (9.7, 24.2) | 1.08 | 0.30 | 0.64 |
PG I | 75.5 (38.5, 101.3) | 71.7 (51.45, 96.3) | 0.49 | 0.49 | 0.82 |
ALT | 16.8 (12.1, 25) | 12.7 (9.3, 17.75) | 0.59 | 0.44 | 0.03 |
AST | 17.1 (14.1, 20.6) | 16.6 (12.25, 19.3) | 0.87 | 0.35 | 0.43 |
TP | 68.3 (64.1, 71.9) | 67.3 (63.15, 70.65) | 0.03 | 0.86 | 0.29 |
ALB | 41.8 (39.6, 44.4) | 39.5 (36.95, 41.45) | 0.63 | 0.43 | 0.07 |
TB | 12.5 (10, 16.4) | 9.7 (7.4, 12.8) | 0.75 | 0.39 | < 0.01 |
DB | 4.1 (3.2, 5.2) | 3.6 (2.3, 4.2) | 0.05 | 0.82 | 0.01 |
TBA | 4.2 (2.5, 7.2) | 3.5 (2.2, 5.7) | 2.15 | 0.14 | 0.11 |
ALP | 61.4 (54.8, 73.6) | 67 (56.4, 80.05) | 2.38 | 0.13 | 0.59 |
GGT | 23.6 (13.5, 37.6) | 22.3 (14.75, 33.95) | 0.01 | 0.95 | 0.98 |
GLu | 5.02 (4.79, 5.51) | 5.12 (4.74, 5.81) | 0.00 | 0.97 | 0.97 |
UN | 5.49 (4.64, 6.08) | 5.23 (4.08, 6.29) | 5.94 | 0.02 | 0.43 |
Cr | 70.2 (61.6, 78.6) | 65.2 (56.35, 75.6) | 0.22 | 0.64 | 0.06 |
UA | 312.3 (257.9, 386.9) | 292.8 (224, 339.4) | 0.19 | 0.67 | 0.06 |
CHO | 4.5 (4.04, 5.27) | 4.36 (3.88, 5.09) | 2.31 | 0.13 | 0.02 |
TG | 1.43 (1.01, 2.01) | 1.25 (0.93, 1.62) | 7.94 | 0.01 | 0.45 |
CK | 69.8 (55.5, 118.9) | 54.4 (35.2, 71.05) | 15.60 | < 0.01 | 0.04 |
LDH | 137 (122.2, 153.3) | 148.4 (129.75, 177.75) | 4.13 | 0.04 | < 0.01 |
CKMB | 6.6 (4, 9.8) | 6.14 (4.05, 9.6) | 1.81 | 0.18 | 0.02 |
Ca | 2.26 (2.19, 2.31) | 2.21 (2.14, 2.27) | 0.10 | 0.75 | 0.47 |
P | 1.27 (1.14, 1.39) | 1.25 (1.07, 1.38) | 0.01 | 0.93 | 0.01 |
Mg | 0.93 (0.85, 1.01) | 0.91 (0.84, 0.97) | 0.01 | 0.94 | 0.29 |
K | 4.03 (3.78, 4.18) | 4.09 (3.87, 4.33) | 4.98 | 0.03 | 0.53 |
Na | 143.8 (141.6, 145.4) | 143.1 (141.45, 144.7) | 0.17 | 0.68 | 0.12 |
Cl | 105.6 (103.4, 107.2) | 105.3 (103.5, 107.4) | 2.08 | 0.15 | 0.04 |
CO2 | 22.6 (20.7, 26.1) | 24.9 (22.9, 26.65) | 2.31 | 0.13 | 0.40 |
LPa | 7.83 (3.01, 12.74) | 15.65 (7.82, 31.65) | 13.29 | < 0.01 | 0.01 |
HDL | 1.27 (1.03, 1.41) | 1.02 (0.89, 1.23) | 0.10 | 0.76 | < 0.01 |
LDL | 2.63 (2.26, 3.28) | 2.54 (2.07, 3.27) | 1.33 | 0.25 | < 0.01 |
ApoA1 | 1.39 (1.17, 1.54) | 1.13 (1.01, 1.34) | 0.66 | 0.42 | 0.55 |
ApoB | 0.83 (0.72, 1.02) | 0.83 (0.72, 1.01) | 0.09 | 0.76 | 0.62 |
CYS | 1.07 (0.95, 1.16) | 0.97 (0.84, 1.08) | 0.34 | 0.56 | 0.70 |
SA | 59.3 (55, 66.5) | 67.1 (60.8, 82.4) | 13.50 | < 0.01 | 0.04 |
HCY | 15.19 (11.54, 19.68) | 13.92 (11.18, 17.42) | 4.71 | 0.03 | < 0.01 |
CRP | 0.7 (0.4, 1.5) | 3.9 (1, 10.55) | 30.41 | < 0.01 | 0.11 |
AMY | 59.5 (50, 73.7) | 51.8 (38.95, 64.7) | 1.18 | 0.28 | < 0.01 |
LPS | 33.1 (25.1, 42.7) | 32.9 (22.25, 44.25) | 2.87 | 0.09 | 0.06 |
SOD | 136.1 (125, 147) | 136.5 (115.8, 156.9) | 4.82 | 0.03 | 0.35 |
IMA | 63.8 (60.1, 66.3) | 62.1 (59.45, 67.5) | 0.11 | 0.74 | < 0.01 |
NDUFB7 | 1.34 (0.94, 2.42) | 2.10 (1.29, 3.08) | 2.666 | 0.105 | 0.155 |
CAMK1D | 34.21 (17.82, 103.44) | 70.39 (35.26, 155.57) | 3.045 | 0.083 | 0.030 |
PIK3CD | 105.90 (36.69, 308.35) | 333.22 (259.40, 417.90) | 3.700 | 0.056 | 0.001 |
PSEN2 | 6.46 (4.44, 11.03) | 8.69 (6.00, 11.67) | 0.144 | 0.705 | 0.154 |
Table 3 Evaluation of the diagnostic value of 26 commonly used clinical indicators with statistical differences (colon polyp group vs colorectal cancer group)
Indicator | AUC | SE | P value | 95% CI | |
Lower | Upper | ||||
IMA | 0.787 | 0.036 | < 0.001 | 0.716 | 0.859 |
CEA | 0.734 | 0.038 | < 0.001 | 0.658 | 0.809 |
SA | 0.728 | 0.039 | < 0.001 | 0.651 | 0.804 |
LPa | 0.715 | 0.042 | < 0.001 | 0.633 | 0.797 |
CK | 0.702 | 0.042 | < 0.001 | 0.619 | 0.784 |
TB | 0.672 | 0.044 | < 0.001 | 0.585 | 0.758 |
HDL | 0.670 | 0.044 | < 0.001 | 0.583 | 0.758 |
NSE | 0.668 | 0.044 | < 0.001 | 0.580 | 0.755 |
ALT | 0.667 | 0.044 | < 0.001 | 0.580 | 0.754 |
Ferr | 0.663 | 0.045 | 0.001 | 0.575 | 0.751 |
DB | 0.646 | 0.044 | 0.002 | 0.559 | 0.733 |
CA125 | 0.642 | 0.044 | 0.003 | 0.557 | 0.728 |
LDH | 0.621 | 0.045 | 0.011 | 0.534 | 0.709 |
AMY | 0.611 | 0.045 | 0.019 | 0.522 | 0.700 |
CY211 | 0.602 | 0.046 | 0.032 | 0.513 | 0.691 |
CA724 | 0.583 | 0.046 | 0.081 | 0.492 | 0.673 |
HCY | 0.570 | 0.048 | 0.138 | 0.476 | 0.664 |
CHO | 0.556 | 0.046 | 0.240 | 0.465 | 0.646 |
P | 0.543 | 0.047 | 0.361 | 0.451 | 0.636 |
LDL | 0.536 | 0.046 | 0.453 | 0.445 | 0.626 |
Cl | 0.525 | 0.047 | 0.603 | 0.432 | 0.618 |
CKMB | 0.516 | 0.047 | 0.736 | 0.424 | 0.608 |
CAMK1D | 0.652 | 0.046 | 0.001 | 0.561 | 0.742 |
PIK3CD | 0.753 | 0.047 | < 0.001 | 0.660 | 0.845 |
Table 4 Univariate Logistic Regression Analysis between the colon polyp group and the colorectal cancer group with statistically significant between-group and receiver operating characteristic indicators
Indicator | B | SE | Wals | P value | Exp (B) | 95% CI | |
Lower | Upper | ||||||
CEA | 0.335 | 0.138 | 5.864 | 0.015 | 1.398 | 1.066 | 1.834 |
IMA | -0.138 | 0.048 | 8.352 | 0.004 | 0.871 | 0.793 | 0.956 |
SA | 0.078 | 0.034 | 5.347 | 0.021 | 1.081 | 1.012 | 1.155 |
LPa | 0.085 | 0.027 | 9.844 | 0.002 | 1.089 | 1.032 | 1.148 |
CK | -0.004 | 0.008 | 0.207 | 0.649 | 0.996 | 0.980 | 1.013 |
TB | -0.065 | 0.054 | 1.463 | 0.226 | 0.937 | 0.843 | 1.041 |
HDL | -0.949 | 0.822 | 1.331 | 0.249 | 0.387 | 0.077 | 1.941 |
NSE | 0.160 | 0.084 | 3.656 | 0.056 | 1.174 | 0.996 | 1.383 |
CHO | -0.004 | 0.017 | 0.053 | 0.817 | 0.996 | 0.964 | 1.029 |
P | 0.886 | 1.104 | 0.644 | 0.422 | 2.426 | 0.279 | 21.139 |
LDL | 0-.585 | 0.368 | 2.534 | 0.111 | 0.557 | 0.271 | 1.145 |
Cl | 0.112 | 0.086 | 1.682 | 0.195 | 1.119 | 0.944 | 1.325 |
CKMB | -0.025 | 0.057 | 0.202 | 0.653 | 0.975 | 0.872 | 1.089 |
CAMK1D | 0.003 | 0.003 | 1.189 | 0.275 | 1.003 | 0.998 | 1.009 |
PIK3CD | 0.003 | 0.001 | 4.429 | 0.035 | 1.003 | 1.000 | 1.005 |
Table 5 Multivariate Logistic Regreesion Analysis Exp (B) Indicators with Statistical Differences (Colon polyp group vs colorectal group)
Indicator | B | SE | Wals | P value | Exp (B) | 95% CI | |
Lower | Upper | ||||||
CEA | 0.326 | 0.109 | 8.904 | 0.003 | 1.385 | 1.118 | 1.716 |
IMA | -0.136 | 0.035 | 14.765 | < 0.001 | 0.873 | 0.815 | 0.936 |
SA | 0.092 | 0.027 | 11.601 | 0.001 | 1.097 | 1.040 | 1.156 |
PIK3CD | 0.002 | 0.001 | 5.852 | 0.016 | 1.002 | 1.000 | 1.004 |
LPa | 0.064 | 0.022 | 8.888 | 0.003 | 1.066 | 1.022 | 1.112 |
Table 6 Multi-parameter combined auxiliary diagnosis model building
Observed | Predicted | ||
CRP | CRC | Correct percentage | |
Binary logistic regression analysis building | |||
CRP | 45 | 14 | 76.30% |
CRC | 15 | 86 | 85.10% |
Total percentage | 81.90% | ||
Discriminant analysis building | |||
CRP | 51 | 8 | 86.40% |
CRC | 31 | 70 | 69.30% |
Total percentage | 75.60% | ||
Classification tree building | |||
CRP | 54 | 5 | 91.50% |
CRC | 42 | 59 | 58.40% |
Total percentage | 70.60% | ||
Neural network building | |||
CRP | 31 | 8 | 79.50% |
CRC | 2 | 68 | 97.10% |
Total percentage | 90.80% | ||
Neural network validation | |||
CRP | 18 | 2 | 90.00% |
CRC | 4 | 27 | 87.10% |
Total percentage | 88.20% |
- Citation: Li J, Jiang T, Ren ZC, Wang ZL, Zhang PJ, Xiang GA. Early detection of colorectal cancer based on circular DNA and common clinical detection indicators. World J Gastrointest Surg 2022; 14(8): 833-848
- URL: https://www.wjgnet.com/1948-9366/full/v14/i8/833.htm
- DOI: https://dx.doi.org/10.4240/wjgs.v14.i8.833