Adult patients with allied disorders of Hirschsprung’s disease in emergency department: An 11-year retrospective study

Table 1 Basic characteristics of adult patients with allied disorders of Hirschsprung’s disease

Basic characteristic	Data (n = 53)
Age (yr)	48.8 ± 14.3
Onset age (yr)	42.8 ± 17.9
Hospitalization days	14.0 (10.0, 21.0)
Sex (n, %)
Male	18 (34.0)
Female	35 (66.0)
Blood type (n, %)
A	10 (18.9)
B	17 (32.1)
AB	6 (11.3)
O	19 (35.8)
Unknown	1 (1.9)
All surgical history (n, %)	25 (47.2)
Abdominal	18 (34.2)
Non-abdominal	7 (13.2)
Smoking (n, %)
Yes	5 (9.4)
No	48 (90.6)
Drinking (n, %)
Yes	2 (3.8)
No	51 (96.2)
Enteroscopy (n, %)
Abnormality	5 (9.4)
Non-abnormality	11 (20.8)
Unexamined	37 (69.8)
Barium enema (n, %)
Intestinal dilation	17 (32.1)
No abnormality	5 (9.4)
Unexamined	31 (58.5)

Table 2 Blood test indices between allied disorders of Hirschsprung’s disease (case group) versus irritable bowel syndrome (control group) patients

Parameter	Case group (n = 53)	Control group (n = 58)	P value
Age (yr)	48.8 ± 14.3	49.8 ± 14.5	0.715
Male (n, %)	18 (34.0%)	24 (41.4%)	0.421
Body mass index (kg/m2)	20.2 (18.8, 21.6)	22.6 (20.3, 25.0)	< 0.001c
White blood cells (× 109/L)	5.4 (3.9, 6.8)	5.4 (4.7, 6.4)	0.512
Neutrocyte proportion (%)	61.0 ± 14.5	57.9 ± 10.0	0.190
Lymphocyte proportion (%)	30.0 ± 14.2	32.1 ± 9.5	0.371
Red blood cells (× 1012/L)	4.3 (4.0, 4.6)	4.4 (4.0, 4.8)	0.064
Hemoglobin (g/L)	128.5 ± 16.2	133.9 ± 21.9	0.141
Platelet count (× 109/L)	214.0 (171.0, 260.5)	213.0 (161.8, 245.0)	0.445
Total protein (g/L)	64.2 ± 9.6	69.3 ± 5.7	0.001b
Albumin (g/L)	41.2 ± 7.1	44.1 ± 4.3	0.014a
Alanine aminotransferase (U/L)	13.0 (9.5, 19.0)	17.0 (10.8, 27.3)	0.061
Aspartate aminotransferase (U/L)	14.0 (17.0, 21.5)	19.0 (15.0, 26.0)	0.090
Cholinesterase (U/L)	6331.0 (4900.5, 7575.0)	7534.0 (6877.8, 9216.8)	< 0.001c
Creatinine (μmol/L)	61.0 ± 14.2	67.2 ± 13.3	0.018a
Triglyceride (mmol/L)	1.0 (0.7, 1.3)	1.2 (0.9, 1.7)	0.013a
Total cholesterol (mmol/L)	3.9 ± 1.0	4.3 ± 0.9	0.013a
Fasting blood glucose (mmol/L)	4.8 (4.3, 5.8)	4.8 (4.0, 5.2)	0.225
Serum potassium (mmol/L)	4.0 ± 0.5	4.1 ± 0.4	0.139
Serum sodium (mmol/L)	141.0 (139.0, 142.0)	142.0 (140.0, 143.0)	0.011a
Blood chlorine (mmol/L)	103.0 (101.0, 105.0)	104.0 (103.0, 106.0)	0.009b
Blood calcium (mmol/L)	2.2 (2.1, 2.3)	2.2 (2.1, 2.3)	0.254
Serum phosphorus (mmol/L)	1.1 ± 0.3	1.2 ± 0.2	0.327

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

Table 3 Prediction of the allied disorders of Hirschsprung’s disease vs irritable bowel syndrome based on multivariate logistic regression model

Value	P value	OR	95%CI
Body mass index	0.013	0.786	0.649-0.951
Cholinesterase, per 1000 units	0.008	0.693	0.527-0.910
Blood chlorine	0.022	0.816	0.686-0.971

OR: Odds ratio; CI: Confidence interval.