Global research production pertaining to gastrointestinal involvement in COVID-19: A bibliometric and visualised study

Table 1 List of the top 10 countries pertaining to gastrointestinal publications involvement in coronavirus disease 2019

Ranking	Country	No. of documents	%	Study population	Sample size	Prevalence of GI symptoms (%)	Common GI symptoms
1st	United States	278	21.94	Multicentre Cohort Study[48]	318	61.3	Loss of appetite, diarrhoea, and nausea
2nd	China	222	17.52	Retrospective study[51]	1320	14.5	Diarrhoea, anorexia, and nausea and vomiting
3rd	Italy	184	14.52	Prospective case-control study[47]	34	8.8	Diarrhoea, abdominal pain, and nausea
4th	United Kingdom	159	12.55	Prospective observational cohort study[42]	20, 133	23	Diarrhoea, nausea/vomiting, and abdominal pain
5th	Spain	61	4.81	Retrospective study[49]	76	75	Diarrhoea, nausea/vomiting, and abdominal pain
6th	France	59	4.66	Retrospective study[45]	114	2.6	Diarrhoea
7th	Germany	56	4.42	Retrospective study[43]	50	> 16	Diarrhoea, nausea/vomiting
8th	India	51	4.03	Prospective study[44]	252	10.3	anorexia, nausea, vomiting, abdominal pain
9th	Australia	37	2.92	Epidemiological study[50]	295	> 16	Diarrhoea, nausea/vomiting, and abdominal pain
10th	Iran	33	2.60	Retrospective study[46]	611	25.4	Nausea/vomiting, diarrhoea, and abdominal pain

GI: Gastrointestinal.

Table 2 List of the top 10 institutions pertaining to gastrointestinal publication involvement in coronavirus disease 2019

Ranking	Institution	Country	n	%
1st	Huazhong University of Science and Technology	China	33	2.60
2nd	Humanitas Research Hospital	Italy	32	2.53
3rd	Humanitas University	Italy	30	2.37
4th	Tongji Medical College	China	29	2.29
5th	INSERM	France	27	2.13
6th	Chinese University of Hong Kong	China	26	2.05
7th	Fondazione Policlinico Universitario Agostino Gemelli IRCCS Università Cattolica del Sacro Cuore	Italy	25	1.97
8th	Università degli Studi di Roma La Sapienza	Italy	22	1.74
9th	Università degli Studi di Milano	Italy	21	1.66
10th	Università degli Studi di Padova	Italy	20	1.58
10th	University Hospitals Birmingham NHS Foundation Trust	United Kingdom	20	1.58

Table 3 List of the top 10 journals pertaining to gastrointestinal publications involvement in coronavirus disease 2019

Ranking	Journal	n	%	Impact factors
1st	Gastroenterology	57	4.50	17.373
2nd	American Journal of Gastroenterology	34	2.68	10.171
2nd	Inflammatory Bowel Diseases	34	2.68	4.261
2nd	Lancet Gastroenterology and Hepatology	34	2.68	14.789
5th	Digestive and Liver Disease	33	2.60	3.570
6th	British Journal of Surgery	29	2.29	5.676
7th	Alimentary Pharmacology and Therapeutics	25	1.97	7.515
8th	Clinical Gastroenterology and Hepatology	21	1.66	8.549
9th	Colorectal Disease	20	1.58	2.769
10th	Journal of Gastroenterology and Hepatology	18	1.42	3.437

Impact factors were retrieved from the 2019 Journal Citation Reports (Clarivate Analytics).

Table 4 List of the top 10 cited articles for gastrointestinal publications involvement in coronavirus disease 2019

Ranking	Ref.	Title	Source title	Cited by	Impact index per article1
1st	Xiao et al[58], 2020	“Evidence for Gastrointestinal Infection of SARS-CoV-2”	Gastroenterology	798	617.5
2nd	Xu et al[59], 2020	“Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding”	Nature Medicine	525	384.0
3rd	Gu et al[52], 2020	“COVID-19: Gastrointestinal Manifestations and Potential Fecal–Oral Transmission”	Gastroenterology	507	342.5
4th	Pan et al[55], 2020	“Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: A descriptive, cross-sectional, multicenter study”	American Journal of Gastroenterology	464	352.5
5th	Wu et al[57], 2020	“Prolonged presence of SARS-CoV-2 viral RNA in faecal samples”	Lancet Gastroenterology and Hepatology	451	374.5
6th	Jin et al[53], 2020	“Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms”	Gut	362	277.0
7th	Cheung et al[10], 2020	“Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples From a Hong Kong Cohort: Systematic Review and Meta-analysis”	Gastroenterology	356	269.5
8th	Lamers et al[54], 2020	“SARS-CoV-2 productively infects human gut enterocytes”	Science	338	317.5
9th	Yeo et al[60], 2020	“Enteric involvement of coronaviruses: is faecal–oral transmission of SARS-CoV-2 possible?”	Lancet Gastroenterology and Hepatology	323	202.0
10th	Tian et al[56], 2020	“Gastrointestinal features in COVID-19 and the possibility of faecal transmission”	Alimentary Pharmacology and Therapeutics	269	189.0

¹The impact index per article is presented based on Reference Citation Analysis [source: Baishideng Publishing Group Inc. (Pleasanton, CA 94566, United States)].