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©The Author(s) 2022.
World J Gastrointest Surg. Feb 27, 2022; 14(2): 143-160
Published online Feb 27, 2022. doi: 10.4240/wjgs.v14.i2.143
Published online Feb 27, 2022. doi: 10.4240/wjgs.v14.i2.143
Table 1 Baseline characteristics of patients with pT1N2-3 and pT3N0 GC, n (%)
Characteristic | pT1N2-3b (n = 89) | pT3N0 (n = 370) | P value |
Sex | < 0.001 | ||
Male | 44 (49.4) | 269 (72.7) | |
Female | 45 (50.6) | 101 (27.3) | |
Age (yr) | 0.071 | ||
≤ 60 | 58 (65.2) | 219 (59.2) | |
> 60 | 25 (34.8) | 151 (40.8) | |
BMI (kg/m2) | 0.964 | ||
< 24 | 63 (70.8) | 261 (70.5) | |
≥ 24 | 26 (29.2) | 109 (29.5) | |
Borrmann type | < 0.001 | ||
0 | 89 (100.0) | 0 (0.0) | |
1 | 0 (0.0) | 23 (6.2) | |
2 | 0 (0.0) | 126 (34.1) | |
3 | 0 (0.0) | 195 (52.7) | |
4 or 5 | 0 (0.0) | 26 (7.0) | |
Tumor diameter (mm) | 0.002 | ||
≤ 50 | 74 (83.1) | 245 (66.2) | |
> 50 | 15 (16.9) | 125 (33.8) | |
Tumor location | 0.007 | ||
Upper | 4 (4.5) | 53 (14.3) | |
Middle | 11 (12.4) | 66 (17.8) | |
Lower | 74 (83.1) | 243 (65.7) | |
Total | 0 (0.0) | 8 (2.2) | |
Gastrectomy | 0.001 | ||
Partial gastrectomy | 83 (93.3) | 289 (78.1) | |
Total gastrectomy | 6 (6.7) | 81 (21.9) | |
Histological type | 0.043 | ||
Differentiated | 32 (36.0) | 177 (47.8) | |
Undifferentiated | 57 (64.0) | 193 (52.2) | |
pT stage | < 0.001 | ||
T1a | 18 (20.2) | 0 (0.0) | |
T1b | 71 (79.8) | 0 (0.0) | |
T3 | 0 (0.0) | 370 (100.0) | |
pN stage | < 0.001 | ||
N0 | 0 (0.0) | 370 (100.0) | |
N2 | 70 (78.7) | 0 (0.0) | |
N3a | 18 (20.2) | 0 (0.0) | |
N3b | 1 (1.1) | 0 (0.0) | |
Vascular infiltration | 0.021 | ||
No | 64 (71.9) | 306 (82.7) | |
Yes | 25 (28.1) | 64 (17.3) | |
Nerve infiltration | < 0.001 | ||
No | 82 (92.1) | 224 (60.5) | |
Yes | 7 (7.9) | 146 (39.5) | |
Postoperative chemotherapy | < 0.001 | ||
Yes | 52 (58.4) | 114 (30.8) | |
No | 37 (41.6) | 256 (69.2) |
Table 2 Univariate and multivariate analyses of clinicopathological factors of patients with pT1N2-3b GC
Characteristic | pT1N2-3b | |||
Univariate analysis | Multivariate analysis | |||
HR (95%CI) | P value | HR (95%CI) | P value | |
Sex | 0.870 | - | - | |
Male | 1.000 | |||
Female | 0.929 (0.387-2.233) | |||
Age (yr) | 1.044 (1.001-1.089) | 0.044 | 1.022 (0.978-1.069) | 0.335 |
BMI (kg/m2) | 0.924 (0.815-1.047) | 0.216 | - | - |
Neutrophils (109/L) | 1.034 (0.795-1.345) | 0.802 | - | - |
Lymphocytes (109/L) | 0.616 (0.297-1.278) | 0.193 | - | - |
Platelets (109/L) | 0.999 (0.992-1.006) | 0.692 | - | - |
Fibrinogen (g/L) | 1.277 (0.723-2.256) | 0.399 | - | - |
ALT (U/L) | 1.000 (0.973-1.029) | 0.972 | - | - |
AST (U/L) | 1.016 (0.968-1.067) | 0.521 | - | - |
Albumin (g/L) | 0.926 (0.833-1.028) | 0.150 | - | - |
Prealbumin (mg/L) | 0.986 (0.977-0.995) | 0.003 | 0.990 (0.981-1.000) | 0.040 |
CEA (ng/mL) | 1.254 (1.074-1.464) | 0.004 | 1.199 (1.028-1.399) | 0.021 |
CA19-9 (U/mL) | 1.000 (0.972-1.028) | 0.992 | - | - |
Tumor diameter (mm) | 0.986 (0.961-1.013) | 0.307 | - | - |
Gastrectomy | 0.683 | - | - | |
Partial gastrectomy | 1.000 | |||
Total gastrectomy | 1.356 (0.314-5.851) | |||
Histological type | 0.324 | - | - | |
Differentiated | 1.000 | |||
Undifferentiated | 1.665 (0.605-4.581) | |||
pN stage | 0.251 | - | - | |
N2 | 1.000 | |||
N3 | 1.752 (0.673-4.562) | |||
mLNR | 47.797 (5.421-421.417) | < 0.001 | 17.488 (1.215-251.748) | 0.035 |
Vascular infiltration | 0.187 | - | - | |
No | 1.000 | |||
Yes | 1.865 (0.738-4.708) | |||
Nerve infiltration | 0.989 | - | - | |
No | 1.000 | |||
Yes | 1.010 (0.234-4.359) | |||
Postoperative chemotherapy | 0.528 | - | - | |
Yes | 1.000 | |||
No | 0.744 (0.297-1.865) |
Table 3 Univariate and multivariate analyses of clinicopathological factors of patients with pT3N0 GC
Characteristic | pT3N0 | |||
Univariate analysis | Multivariate analysis | |||
HR (95%CI) | P value | HR (95%CI) | P value | |
Sex | 0.087 | - | - | |
Male | 1.000 | |||
Female | 1.533 (0940-2.500) | |||
Age (yr) | 1.029 (1.005-1.054) | 0.019 | 1.025 (1.001-1.049) | 0.039 |
BMI (kg/m2) | 0.890 (0.822-0.964) | 0.004 | 0.881 (0.812-0.955) | 0.002 |
Neutrophils (109/L) | 0.947 (0.829-1.082) | 0.421 | - | - |
Lymphocytes (109/L) | 0.966 (0.719-1.298) | 0.819 | - | - |
Platelets (109/L) | 1.000 (0.997-1.003) | 0.914 | - | - |
Fibrinogen (g/L) | 1.048 (0.974-1.129) | 0.210 | - | - |
ALT (U/L) | 0.992 (0.969-1.015) | 0.469 | - | - |
AST (U/L) | 1.012 (0.986-1.037) | 0.369 | - | - |
Albumin (g/L) | 0.991 (0.949-1.034) | 0.670 | - | - |
Prealbumin (mg/L) | 1.657 (0.954-2.005) | 0.087 | - | - |
CEA (ng/mL) | 1.007 (0.985-1.030) | 0.535 | - | - |
CA19-9 (U/mL) | 1.002 (0.999-1.004) | 0.214 | - | - |
Tumor diameter (mm) | 1.011 (1.004-1.019) | 0.003 | 1.000 (0.990-1.010) | 0.981 |
Borrmann type | 0.018 | 0.282 | ||
1 | 1.000 | 1.000 | ||
2 | 0.368 (0.159-0.853) | 0.020 | 0.473 (0.195-1.150) | 0.099 |
3 | 0.520 (0.242-1.119) | 0.095 | 0.620 (0.279-1.377) | 0.240 |
4 or 5 | 1.110 (0.428-2.879) | 0.830 | 1.051 (0.379-2.911) | 0.924 |
Gastrectomy | < 0.001 | < 0.001 | ||
Partial gastrectomy | 1.000 | 1.000 | ||
Total gastrectomy | 3.378 (2.105-5.421) | 3.222 (1.945-5.338) | ||
Histological type | 0.380 | - | - | |
Differentiated | 1.000 | |||
Undifferentiated | 1.236 (0.771-1.980) | |||
Vascular infiltration | 0.237 | - | - | |
No | 1.000 | |||
Yes | 1.142 (0.798-2.499) | |||
Nerve infiltration | 0.373 | - | - | |
No | 1.000 | |||
Yes | 1.240 (0772-1.991) | |||
Postoperative chemotherapy | 0.238 | - | - | |
Yes | 1.000 | |||
No | 0.774 (0.430-1.393) |
- Citation: Wang YF, Yin X, Fang TY, Wang YM, Zhang DX, Zhang Y, Wang XB, Wang H, Xue YW. Nomograms predicting prognosis of patients with pathological stages T1N2-3 and T3N0 gastric cancer. World J Gastrointest Surg 2022; 14(2): 143-160
- URL: https://www.wjgnet.com/1948-9366/full/v14/i2/143.htm
- DOI: https://dx.doi.org/10.4240/wjgs.v14.i2.143