Current status of liver transplantation for cholangiocarcinoma

Table 1 Studies assessing patient survival and disease-free survival after receiving a liver transplant for intrahepatic cholangiocarcinoma

Ref.	Study type	Number of LT patients	Overall survival (%)			DFS at 5-yr (%)	Comments
			1-yr	3-yr	5-yr	No
iCCA
O’Grady et al[51], 1988	Retrospective	13	38	10	10	-
Yokoyama et al[52], 1990	Retrospective	2	50	0	-	-
Meyer et al[53], 2000	Retrospective Multicenter	207	72	48	23	-	84% DFS at 25 mo
Shimoda et al[54], 2001	Retrospective	16	62	39	-	35
Robles et al[55], 2004	Retrospective multicenter	23	77	65	42	-	2 yr DFS 35%
Sotiropoulos et al[56], 2009	Retrospective	10	70	50	33	-
Fu et al[57], 2011	Retrospective	11	50.5	50.5			3 yr DFS 51.9%
Hong et al[8], 2011	Retrospective	25	-	38	32	33
Vallin et al[58], 2013	Retrospective multicenter	10	80	60	24	-
Facciuto et al[29], 2015	Retrospective	7 iCCA; 9 iCCA + HCC; 16 iCCA-HCC	71	-	57	44
Vilchez et al[59], 2016	Retrospective multicenter	440	79	58	47	-
Very early iCCA (< 2 cm)
Sapisochin et al[28], 2014	Retrospective multicenter	27	78	66	51	36
Sapisochin et al[30], 2016	Retrospective multicenter	15 single < 2 cm; 33 multiple or > 2 cm	93; 79	84; 50	65; 45	82; 39
Locally advanced iCCA with sustained response to chemotherapy
Lunsford et al[5], 2018	Prospective single-arm	6	100	83.3	83.3	50

LT: Liver transplant; DFS: Disease free survival; iCCA: Intrahepatic cholangiocarcinoma; HCC: Hepatocellular carcinoma.