Prognostic predictors in patients with sepsis after gastrointestinal tumor surgery: A retrospective study

Table 1 Baseline characteristics of sepsis patients

Baseline characteristic	n (%)
Age, median (Q1, Q3)	65 (59.71)
Sex
Male	145 (80.1)
Female	36 (19.9)
BMI, mean (SD), kg/m2	23.5 (0.3)
Tumor type
Gastric cancer	91 (50.3)
Colorectal cancer	84 (46.4)
Other abdominal tumors	6 (3.3)
Coexisting condition1
Hypertension	64 (35.4)
Diabetes	32 (17.7)
Coronary heart disease	17 (9.4)
Chronic obstructive pulmonary disease	11 (6.1)
Arrhythmia	9 (5.0)
Chronic renal insufficiency	2 (1.1)
Location of infection2
Abdominal infection	134 (74.0)
Enterogenous infection	12 (6.6)
Intrathoracic infection	17 (9.4)
Pulmonary infection	31 (17.1)
Skin and soft tissue infection	6 (3.3)
Surgical wound infection	4 (2.2)
Central line-associated bloodstream infection	3 (1.7)
Urinary tract infection	2 (1.1)
Length of first operation, median (Q1, Q3), min	195 (140, 246)

¹Twenty-seven patients had two or more chronic diseases.

²Thirty-one patients were infected in two or more locations.

Q1: Quartile 1; Q3: Quartile 3; BMI: Body mass index.

Table 2 Univariate analysis of sepsis patients

Parameter	n (%)	Survival rate at 90-d	P value
Age, yr			0.840
≤ 65	96 (53.0)	0.885
> 65	85 (47.0)	0.894
Sex			0.254
Male	145 (80.1)	0.876
Female	36 (19.9)	0.944
BMI, kg/m2			0.028
≤ 20	37 (20.4)	0.784
20 < BMI ≤ 28	118 (65.2)	0.932
> 28	26 (14.4)	0.846
Length of first operation, min			0.361
≤ 240	129 (71.3)	0.876
> 240	52 (28.7)	0.923
Empirical anti infection evaluation			0.729
Sensitive	132 (72.9)	0.894
Resistance	18 (10.0)	0.833
No pathogen detected	31 (17.1)	0.903
Shock within 48 h after ICU admission			0.001
No	95 (52.5)	0.979
Yes	86 (47.5)	0.791
Leukocyte count, 109/L			0.010
≤ 4	31 (17.1)	0.774
4 < WBC ≤ 12	77 (42.6)	0.963
> 12	73 (40.3)	0.863
Lymphocyte to neutrophil ratio			0.035
≤ 0.15	148 (81.8)	0.912
> 0.15	33 (18.2)	0.788
International standardized ratio			0.001
≤ 1.5	127 (70.2)	0.937
> 1.5	54 (29.8)	0.778
Activated partial thromboplastin time, s			0.064
≤ 50	138 (76.2)	0.913
> 50	43 (23.8)	0.814
Albumin, g/L			0.058
≤ 30	99 (54.7)	0.848
> 30	82 (45.3)	0.939
Creatinine, μmol/L			0.001
≤ 120	150 (82.9)	0.927
> 120	31 (17.1)	0.710
Cardiac troponin I, ng/mL			0.063
≤ 0.05	138 (76.2)	0.913
> 0.05	43 (23.8)	0.814
Procalcitonin, ng/mL			0.011
≤ 5	93 (51.4)	0.946
> 5	88 (48.6)	0.830
Lactic acid, mmol/L			0.001
≤3	128 (70.7)	0.938
> 3	53 (29.3)	0.774
Oxygenation index, mmHg			0.003
≤ 200	97 (53.6)	0.825
> 200	84 (46.4)	0.964
SOFA score			0.001
≤ 8	124 (68.5)	0.968
> 8	57 (31.5)	0.719

BMI: Body mass index; ICU: Intensive care unit; WBC: White blood cell; SOFA: Sequential organ failure assessment.

Table 3 Multiple analysis of sepsis patients

Factor	RR	95%CI		P value
		Lower limit	Upper limit
BMI (Ref)				0.011
BMI (1)	1.778	0.532	5.942	0.350
BMI (2)	0.377	0.113	1.262	0.114
Lactic acid	2.950	1.168	7.450	0.022
SOFA score	8.359	2.741	25.496	0.001

BMI: Body mass index; SOFA: Sequential organ failure assessment; RR: Risk ratio; CI: Confidence interval