Clinical Trials Study
Copyright ©The Author(s) 2020.
World J Gastrointest Surg. Dec 27, 2020; 12(12): 520-533
Published online Dec 27, 2020. doi: 10.4240/wjgs.v12.i12.520
Table 1 Demographics of 50 patients with maximum dominant tumor diameter > 6 cm
 Parameter
Median
Min-Max
Age (yr)568-72
MELD score106-28
AFP (ng/mL)24.50.8-12863
Platelets (103/uL)11216-528
NLR2.750.3-13.3
PLR97.125.7-302.9
Albumin (g/dL)31.9-4.2
Total bilirubin (mg/dL)1.580.23-13.9
GGT (IU/L)111.517-1396
AST (IU/L)76.519-566
ALT (IU/L)5010-657
MTD (cm)8.56.4-24
Number of nodules21-20
Table 2 Demographics of 50 patients with maximum dominant tumor diameter > 6 cm
Parameter
n
%
Gender, male4182
Child-Pugh score
A1938
B2652
C510
Etiology
Viral hepatitis4080
Cryptogenic714
Fibrolamellar-HCC12
Budd-Chiari12
Ethanol12
Differentiation
Well1632
Moderate2652
Poor816
Microvascular invasion negative1530
Microvascular invasion positive3570
TACE/TARE/RFA (+)816
Table 3 Clinical characteristics of 50 hepatocellular carcinoma patients, maximum dominant tumor diameter > 6 cm, according to serum gamma glutamyl transpeptidase or alpha-fetoprotein levels
ParametersLow GGT ≤ 104, n = 20, median (min-max)High GGT > 104, n = 28, median (min-max)P valueLow AFP ≤ 200, n = 36, median (min-max)High AFP > 200, n = 14, median (min-max)P value
AFP (ng/mL)20.1 (0.8-6388)45.7 (1.9-12863)0.818
GGT (IU/L)114 (17-1396)106 (29-393)0.862
AST (IU/L)76.5 (19-566)71 (25-313)0.54481 (19-566)76 (28-245)0.596
Total Bilirubin (mg/dl)1.7 (0.23-13.9)1.7 (0.38-13.9)0.6601.78 (0.23-13.9)1.13 (0.38-11.7)0.270
MTD (cm)8.5 (6.5-22)8.5 (6.4-24)0.9928.5 (6.4-24)8.5 (6.5-22)0.896
Microvascular invasion, n (%)0.04a0.360
Negative9 (45)5 (18)11 (31)4 (29)
Positive11 (55)23 (82)25 (69)10 (71)
Differentiation, n (%)
Well11 (55)4 (15)0.011a13 (36)3 (21)0.324
Moderate7 (35)18 (64)19 (53)7 (50)
Poor2 (10)6 (21)4 (11)4 (29)
Number of nodules
110 (50)12 (43)0.84516 (44)6 (43)1.000
> 110 (50)16 (57)20 (56)8 (57)
Table 4 Clinical characteristics of combination low alpha-fetoprotein/gamma glutamyl transpeptidase patients vs all other combinations
ParametersLow AFP ≤ 200, low GGT ≤ 104, n = 14Other combos, n = 34P value
AFP (ng/mL)
Median7.35132.50.009b
mean ± SD21.6 ± 32.4758.5 ± 2397.2
GGT (IU/L)
Median63140.5< 0.001c
mean ± SD59.6 ± 31.6208.9 ± 232.4
Total Bilirubin (mg/dL)
Median21.40.511
mean ± SD3.2 ± 3.82.5 ± 3.0
AST (IU/L)
Median68.577.50.892
mean ± SD126.2 ± 145.993.2 ± 66.4
MTD (cm)
Median8.758.250.317
mean ± SD8.66 ± 1.189.9 ± 4.5
Number of nodules, n (%)
18 (57)14 (41)0.490
> 16 (43)20 (59)
Microvascular invasion, n (%)
Negative7 (50)7 (21)0.041a
Positive7 (50)27 (79)
Differentiation, n (%)
Well7 (50)7 (20)0.020a
Moderate5 (36)19 (56)
Poor2 (14)8 (24)