Ince V, Carr BI, Bag HG, Ersan V, Usta S, Koc C, Gonultas F, Sarici BK, Karakas S, Kutluturk K, Baskiran A, Yilmaz S. Liver transplant for large hepatocellular carcinoma in Malatya: The role of gamma glutamyl transferase and alpha-fetoprotein, a retrospective cohort study. World J Gastrointest Surg 2020; 12(12): 520-533 [PMID: 33437403 DOI: 10.4240/wjgs.v12.i12.520]
Corresponding Author of This Article
Volkan Ince, FEBS, MD, Associate Professor, Surgeon, Department of General Surgery, Inonu University, Liver Transplantation Institute, Battalgazi, Malatya 44280, Turkey. volkanince@outlook.com
Research Domain of This Article
Transplantation
Article-Type of This Article
Clinical Trials Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Dec 27, 2020; 12(12): 520-533 Published online Dec 27, 2020. doi: 10.4240/wjgs.v12.i12.520
Table 1 Demographics of 50 patients with maximum dominant tumor diameter > 6 cm
Parameter
Median
Min-Max
Age (yr)
56
8-72
MELD score
10
6-28
AFP (ng/mL)
24.5
0.8-12863
Platelets (103/uL)
112
16-528
NLR
2.75
0.3-13.3
PLR
97.1
25.7-302.9
Albumin (g/dL)
3
1.9-4.2
Total bilirubin (mg/dL)
1.58
0.23-13.9
GGT (IU/L)
111.5
17-1396
AST (IU/L)
76.5
19-566
ALT (IU/L)
50
10-657
MTD (cm)
8.5
6.4-24
Number of nodules
2
1-20
Table 2 Demographics of 50 patients with maximum dominant tumor diameter > 6 cm
Parameter
n
%
Gender, male
41
82
Child-Pugh score
A
19
38
B
26
52
C
5
10
Etiology
Viral hepatitis
40
80
Cryptogenic
7
14
Fibrolamellar-HCC
1
2
Budd-Chiari
1
2
Ethanol
1
2
Differentiation
Well
16
32
Moderate
26
52
Poor
8
16
Microvascular invasion negative
15
30
Microvascular invasion positive
35
70
TACE/TARE/RFA (+)
8
16
Table 3 Clinical characteristics of 50 hepatocellular carcinoma patients, maximum dominant tumor diameter > 6 cm, according to serum gamma glutamyl transpeptidase or alpha-fetoprotein levels
Citation: Ince V, Carr BI, Bag HG, Ersan V, Usta S, Koc C, Gonultas F, Sarici BK, Karakas S, Kutluturk K, Baskiran A, Yilmaz S. Liver transplant for large hepatocellular carcinoma in Malatya: The role of gamma glutamyl transferase and alpha-fetoprotein, a retrospective cohort study. World J Gastrointest Surg 2020; 12(12): 520-533