Transmembrane serine protease 4 expression in the prognosis of radical resection for biliary tract cancer

Figure 1 Immunohistochemical staining of transmembrane serine protease 4 in biliary tract cancer. A: Transmembrane serine protease 4 (TMPRSS4)-positive biliary tract cancer (BTC) tissues; B: TMPRSS4-positive BTC tissues; C: TMPRSS4-negative BTC tissues; D: TMPRSS4-negative BTC tissues. Original magnification: 40 × (A and C); 400 × (B and D).

Figure 2 Kaplan–Meier curves for all patients with biliary tract cancer classified based on the expression of transmembrane serine protease 4. A: Overall survival after surgery for all patients with biliary tract cancer (BTC), classified according to the expression of transmembrane serine protease 4 (TMPRSS4); B: Recurrence-free survival after surgery for all patients with BTC, classified according to the expression of TMPRSS4. TMPRSS4: Transmembrane serine protease 4.

Figure 3 Overall survival after surgery for each disease, classified according to transmembrane serine protease 4 expression. A: Perihilar cholangiocarcinoma; B: Distal cholangiocarcinoma; C: Gallbladder cancer; D: Ampulla of vater cancer. TMPRSS4: Transmembrane serine protease 4.