Prognostic role of serum carcinoembryonic antigen in patients receiving liver resection for colorectal cancer liver metastasis: A meta-analysis

Figure 1 Literature screening process. CEA: Carcinoembryonic antigen.

Figure 2 Forest plot of the correlation between high preoperative serum carcinoembryonic antigen levels and overall survival, disease-free survival, recurrence-free survival. A: Forest plot of the correlation between high preoperative serum carcinoembryonic antigen (CEA) levels and overall survival. In the study of Arru et al[65], the hazard ratio (HR) [95% confidence interval (CI)] for CEA levels > 5 ng/mL was 2.10 (1.10-3.90), and the HR (95%CI) for CEA levels < 5 ng/mL was 1.60 (0.70-3.70); B: Forest plot of the correlation between high preoperative serum CEA levels and disease-free survival; C: Forest plot of the correlation between high preoperative serum CEA levels and recurrence-free survival. In the study of Kawahara et al[36], the HR (95%CI) for CEA levels > 50 ng/mL was 2.15 (0.94-4.94), and the HR (95%CI) for CEA levels < 50 ng/mL was 1.51 (0.57-3.95). HR: Hazard ratio; CI: Confidence interval.

Figure 3 Forest plot of the correlation between high postoperative serum carcinoembryonic antigen levels and overall survival, disease-free survival, recurrence-free survival. A: Forest plot of the correlation between high postoperative serum carcinoembryonic antigen (CEA) levels and overall survival; B: Forest plot of the correlation between high postoperative serum CEA levels and disease-free survival; C: Forest plot of the correlation between high postoperative serum CEA levels and recurrence-free survival. HR: Hazard ratio; CI: Confidence interval.