Analysis of nutritional risk, skeletal muscle depletion, and lipid metabolism phenotype in acute radiation enteritis

Figure 1 Metabolomics analysis of fecal supernatants of patients with cervical cancer during the periradiation period. A-D: Interaction pathways of differential metabolites in stool supernatant samples of patients undergoing radiotherapy for cervical cancer; A: Kyoto Encyclopedia of Genes and Genomes network level (yellow is the differential metabolite); B: Differential metabolite level; C: Co-differential metabolite level with time characteristics; D: Representative differential metabolic pathway levels; E: 26 co-differential metabolites selected in stool samples; F: Pathway impact factor diagram of stool supernatant samples; G: N-formyl-L-methionine; H: Cholic acid; I: Linoleic acid (LC); J: Arachidonic acid (AA) (metabolic changes in enoic acids, from left to right). 1: LC metabolic pathway; 2: AA metabolic pathway; 3: Phenylalanine metabolic pathway).

Figure 2 Incidence of radiation-induced acute intestinal symptoms in patients with cervical cancer and changes in the nutritional risk screening 2002 score, blood biochemical indicators, and body composition during the periradiation period. A: Diarrhea, abdominal pain, colitis, anal swelling, hematochezia, and bone marrow suppression in patients with cervical cancer; B-I: Changes in clinical observation indices during periradiation therapy, nutritional risk screening (NRS) 2002 score (B), body weight (C), body mass index (BMI) (D), serum albumin (E), serum prealbumin (F), body fat content (G), skeletal muscle content (H), and phase angle change (I) during periradiation therapy in patients with cervical cancer; J: Correlation analysis of body weight, BMI, skeletal muscle content, body fat content, phase angle, serum albumin, serum prealbumin, NRS 2002 score, and linoleic acid (LC) content in stool supernatant (red indicates positive correlation, blue indicates a negative correlation, and the value in the box is the correlation system R²). RIAIS: Radiation-induced acute intestinal symptoms.