Isolated colonic neurofibroma in the setting of Lynch syndrome: A case report and review of literature

Figure 1 Endoscopic imaging of gastrointestinal neurofibroma. A: A 2.5 cm polypoid lesion was identified within a haustral fold adjacent to the cecum. B: The lesion demonstrated abnormal mucosa with central tethering suspicious for malignancy. C: Magnified view of polypoid lesion with abnormal mucosa concerning for adenocarcinoma.

Figure 2 Pathologic examination of gastrointestinal neurofibroma. A: Low power view of submucosal spindle cell proliferation, (hematoxylin-eosin, 2.5 ×). B: Higher power view of monomorphic spindle cells with intermixed mast cells, (hematoxylin-eosin, 10 ×). C: Immunohistochemistry staining showing variable positivity of lesional cells for S100 protein (10 ×).