Vitamin D levels in subjects with or without chronic kidney disease among Veterans with diabetes in North East United States

Table 1 Clinical and biochemical parameters in all subjects with diabetes (n = 27098)

Parameter	Mean ± SD
Age	68 ± 11
BMI	32 ± 7
DM duration (yr)	5.6 ± 3.2
HTN (%)	94
Vit D	27 ± 11.6
Cre	1.38 ± 0.9
eGFR	66 ± 24
Calcium	9.5 ± 0.5
Glucose	142 ± 64
HbA1C	7.2 ± 1.4
PTH	126 ±121
1,25 Vit D	28 ± 16
IHD (%)	24

BMI: Body mass index; Dur of DM: Duration of diabetes; HTN: Hypertension; Vit D: Vitamin D; Cre: Creatinine; PTH: Parathyroid hormone; IHD: Ischemic heart disease.

Table 2 Clinical and laboratory parameters in subjects with diabetes with glomerular filtration rate < 60 compared to those with glomerular filtration rate ≥ 60

	Mean ± SD eGFR ≥ 60	Mean ± SD eGFR < 60	P value
Age	64.9 ± 11	72.5 ± 10	0
BMI	32 ± 7	31.5 ± 6.5	1.09E-16
Dur of DM	5.2 ± 3.2	6.33 ± 3	1.90E-165
HTN	92%	97%	2.10E-99
Vit D	27 ± 11.5	26.6 ± 12	0.751554
Cre	1.0 ± 0.16	2.02 ± 1.3	0
eGFR	81 ± 16	41.6 ± 13	0
Calcium	9.6 ± 0.46	9.4 ± 0.6	4.23E-97
Glu	141 ± 60	144 ± 68	4.25E-05
HbA1C	7.2 ± 1.46	7.25 ± 1.4	0.018789
PTH	64 ± 43	152 ± 133	1.20E-236
1,25 Vit D	34.8 ± 16	25 ± 14	1.30E-20

GFR: Glomerular filtration rate; BMI: Body mass index; Cre: Creatinine; HTN: Hypertension; Vit D: Vitamin D; PTH: Parathyroid hormone.

Table 3 Clinical and laboratory parameters in subjects with diabetes mellitus with vitamin D levels < 20 and > 20

	Vit D < 20 Mean ± SD	Vit D > 20 Mean ± SD	P-value
Age	66 ± 12	68 ± 11	2.53E-08
BMI	33 ± 7	32 ± 6	5.09E-12
HTN (%)	93	90	NS
25, OH Vit D	14.2 ± 4	32 ± 9	0
Creatinine	1.4 ± 1.0	1.3 ± 0.8	4.60E-130
eGFR	67 ± 26	67 ± 24	7.96E-23
Calcium	9.5 ± 1.4	9.6 ± 1.8	1.20E-208
Glucose	148 ± 69	136 ± 56	1.20E-111
HbA1C	7.4 ± 1.6	7.0 ± 1.3	2.50E-139
PTH	142 ± 174	117 ± 119	2.86E-89

GFR: Glomerular filtration rate; BMI: Body mass index; HTN: Hypertension; Vit D: Vitamin D; PTH: Parathyroid hormone.

Table 4 Clinical and laboratory parameters in subjects with end stage renal disease and with or without diabetes mellitus

	Diabetes (407) Mean ± SD	Without diabetes (173) Mean ± SD	P-value
Age	67 ± 2	68 ± 4	0.0824
BMI	30.5 ± 2	25.2 ± 4	3.00E-13
HTN (%)	98	91
25 (OH Vit D)	24 ± 1.4	24 ± 1.6	0.129
Creatinine	6.6 ± 1.1	7.1 ± 1.1	0.2588
eGFR	10 ± 2	9.1 ± 2.2	0.5871
Calcium	8.9 ± 0.1	8.9 ± 1.1	0.2059
Glucose	147 ± 12	104 ± 8	3.00E-47
HbA1C	6.8 ± 1.4	5.5 ± 0.4	9.29E-16
PTH	353 ± 305	346 ± 290	0.4339

GFR: Glomerular filtration rate; BMI: Body mass index; HTN: Hypertension; Vit D: Vitamin D; PTH: Parathyroid hormone.