Linagliptin alleviates fatty liver disease in diabetic db/db mice

doi:10.4239/wjd.v7.i19.534

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World Journal of Diabetes

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World J Diabetes. Nov 15, 2016; 7(19): 534-546
Published online Nov 15, 2016. doi: 10.4239/wjd.v7.i19.534

Table 1 Body weight and plasma biochemical parameters of the placebo-treated and linagliptin-treated db/db mice at the 10th, 14^th and 18^th week of age

Parameters	Placebo group (n = 8)			Linagliptin group (n = 8)
Parameters	10 wk	14 wk	18 wk	10 wk	14 wk	18 wk
Body weight, g	35.1 (25.6-47.7)	33.2 (24.6-50.9)	37.3 (27.3-51.6)	37.6 (34.5-44.2)	39.9 (30.0-42.3)	41.7 (31.5-45.0)
Glucose, mg/dL	637 (549-678)	579 (551-671)	610 (506-683)	651 (631-693)	588 (520-640)	625 (601-646)
Triglycerides, mg/dL	415 (209-510)	324 (209-336)	316 (149-555)	385 (262-637)	279 (251-315)	391 (238-480)
Total cholesterol, mg/dL	129 (94-156)	100 (39-140)	131 (22-156)	112 (28-132)	104 (24-124)	71 (18-120)
ALT, U/L	132 (105-375)	126 (72-369)	170 (69-306)	146 (84-255)	185 (118-225)	203 (80-294)
GGT, U/L	16.7 (8.2-28.1)	13 (8.5-25.1)	14.6 (10.5-16.5)	14.4 (8.9-18.7)	12.5 (7.1-22)	13.6 (10.5-22.7)

Data are shown as the medians, minimal and maximal values. No significant differences in the variables in both groups at week 10 and 18 (Wilcoxon signed rank test, all P > 0.05). The differences between groups are not significant at week 10, 14 and 18 (U-test, all P > 0.05). ALT: Alanine aminotransferase; GGT: Gamma-glutamyl transpeptidase.

Citation: Michurina SV, Ishenko IJ, Klimontov VV, Archipov SA, Myakina NE, Cherepanova MA, Zavjalov EL, Koncevaya GV, Konenkov VI. Linagliptin alleviates fatty liver disease in diabetic db/db mice. World J Diabetes 2016; 7(19): 534-546
URL: https://www.wjgnet.com/1948-9358/full/v7/i19/534.htm
DOI: https://dx.doi.org/10.4239/wjd.v7.i19.534