Copyright
©The Author(s) 2016.
World J Diabetes. Nov 15, 2016; 7(19): 483-514
Published online Nov 15, 2016. doi: 10.4239/wjd.v7.i19.483
Published online Nov 15, 2016. doi: 10.4239/wjd.v7.i19.483
Table 1 Composition and body fat distribution after three dietary interventions in insulin-resistant subjects
Baseline | High-SAT | High-MUFA | High-CHO | P | |
EE, (kJ/min) | 5.36 ± 0.40 | 5.49 ± 3.90 | 5.23 ± 0.37 | 5.02 ± 0.36 | 0.3 |
Anthropometry | |||||
Weight, kg | 84.4 ± 5.7 | 83.2 ± 5.7 | 83.6 ± 5.8 | 81.8 ± 6.03 | 0.3 |
Total body fat, kg | 36.8 ± 4.1 | 35.0 ± 4.0 | 35.6 ± 4.0 | 34.9 ± 4.3 | 0.1 |
Lean body mass, kg | 47.5 ± 2.5 | 48.1 ± 2.5 | 48.9 ± 2.6 | 46.8 ± 2.1 | 0.2 |
Waist to hip ratio | 0.99 ± 0.01 | 0.99 ± 0.01 | 0.98 ± 0.01 | 0.98 ± 0.01 | 0.9 |
DEXA analysis | |||||
Total body trunk, g | - | 37101 ± 2026 | 38154 ± 1911 | 39134 ± 2104 | 0.3 |
Fatty body trunk, g | - | 14313 ± 1362 | 14842 ± 1437 | 16459 ± 1653 | < 0.05 |
Total body limb, g | - | 36420 ± 3886 | 36239 ± 3862 | 32887 ± 3825 | 0.7 |
Fat in arm, g | - | 7097 ± 1528 | 7652 ± 1339 | 7225 ± 1830 | 0.4 |
Fat in leg, g | - | 8517 ± 1588 | 8036 ± 1398 | 7358 ± 1253 | < 0.05 |
Fat trunk:fat leg ratio | - | 1.9 ± 0.3 | 2.1 ± 0.2 | 2.50 ± 0.2 | < 0.05 |
Table 2 Gene expression ARRAYS of peripheral-white adipose tissue in fasting state and its responses to postprandial specific diets and insulin stimulus
Baseline (n = 8) | P1 | High-MUFA (n = 9) | High-SAT (n = 9) | High-CHO (n = 9) | P2 | Postinsulin (n = 9) | P3 | P4 | |
INSR | 6.74 ± 0.11 | 0.69 | 6.94 ± 0.06 | 6.95 ± 0.01 | 6.98 ± 0.04 | 0.95 | 6.99 ± 0.04 | 0.93 | 0.10 |
GCGR | 6.25 ± 0.13 | 0.03 | 5.92 ± 0.06 | 5.90 ± 0.07 | 5.89 ± 0.06 | 0.95 | 5.75 ± 0.07 | 0.93 | 0.04 |
BMP7 | 4.80 ± 0.08 | 0.69 | 4.49 ± 0.07 | 4.45 ± 0.09 | 4.53 ± 0.11 | 0.95 | 4.55 ± 0.09 | 0.93 | 0.33 |
BMP2 | 6.21 ± 0.10 | 0.62 | 5.89 ± 0.09 | 5.96 ± 0.06 | 5.92 ± 0.09 | 0.95 | 5.89 ± 0.07 | 0.93 | 0.12 |
PPARG | 9.06 ± 0.28 | 0.11 | 9.64 ± 0.08 | 9.44 ± 0.10 | 9.57 ± 0.09 | 0.95 | 9.97 ± 0.13 | 0.14 | 0.04 |
ADIPOQ | 10.89 ± 0.4 | 0.69 | 11.65 ± 0.06 | 11.33 ± 0.22 | 11.46 ± 0.11 | 0.95 | 11.53 ± 0.16 | 0.93 | 0.10 |
LEP | 9.37 ± 0.34 | 0.60 | 9.87 ± 0.16 | 9.64 ± 0.22 | 9.91 ± 0.18 | 0.95 | 10.11 ± 0.14 | 0.93 | 0.04 |
ADRβ3 | 5.23 ± 0.12 | 0.69 | 5.06 ± 0.12 | 5.01 ± 0.10 | 5.05 ± 0.17 | 0.95 | 5.22 ± 0.11 | 0.93 | 0.82 |
RETN | 6.19 ± 0.05 | 0.02 | 5.59 ± 0.10 | 5.63 ± 0.07 | 5.72 ± 0.09 | 0.95 | 5.68 ± 0.08 | 0.93 | 0.10 |
IL-6 | 4.33 ± 0.12 | 0.69 | 4.24 ± 0.10 | 4.27 ± 0.08 | 4.43 ± 0.16 | 0.95 | 4.26 ± 0.11 | 0.93 | 0.60 |
IL6R | 6.50 ± 0.08 | 0.11 | 6.83 ± 0.06 | 6.86 ± 0.06 | 6.86 ± 0.07 | 0.95 | 6.85 ± 0.05 | 0.93 | 0.10 |
TNF-α | 5.25 ± 0.05 | 0.69 | 5.11 ± 0.07 | 5.13 ± 0.06 | 5.26 ± 0.08 | 0.95 | 5.08 ± 0.07 | 0.93 | 0.10 |
TNFRSF1A | 7.49 ± 0.11 | 0.69 | 7.68 ± 0.05 | 7.79 ± 0.07 | 7.74 ± 0.06 | 0.95 | 7.70 ± 0.06 | 0.93 | 0.38 |
TNFRSF1B | 8.19 ± 0.09 | 0.20 | 8.51 ± 0.04 | 8.52 ± 0.04 | 8.56 ± 0.03 | 0.95 | 8.52 ± 0.04 | 0.93 | 0.10 |
- Citation: Paniagua JA. Nutrition, insulin resistance and dysfunctional adipose tissue determine the different components of metabolic syndrome. World J Diabetes 2016; 7(19): 483-514
- URL: https://www.wjgnet.com/1948-9358/full/v7/i19/483.htm
- DOI: https://dx.doi.org/10.4239/wjd.v7.i19.483