Review
Copyright ©The Author(s) 2015.
World J Diabetes. Jul 25, 2015; 6(8): 1057-1064
Published online Jul 25, 2015. doi: 10.4239/wjd.v6.i8.1057
Table 1 Accepted cut-off values of 25 hydroxyvitamin D3 (25OHD3) that describe vitamin D status
Vitamin D status25OHD3 (nmol/L)1
Sufficient (optimal)> 75
Insufficient50-75
Deficient< 50
Table 2 Data of selected epidemiological studies on the relation between vitamin D level and markers of insulin resistance (A), insulin resistance (B) and type 2 diabetes (C)
Ref.No. of subjectsAge, mean or rangeTrial outcome
(A)
Jorde et al[47]102295825OHD negatively associated with BMI
Lee et al[49]9568, 47-9125OHD negatively related to BMI
Lagunova et al[50]1028-19↑ prevalence of Vit D Def. (19%) and insuff. (> 50%) in obese
Suijder et al[60]453> 65↑ BMI is associated with ↓ 25OHD
(B)
Chiu et al[27]12526+ve relation between 25OHD and insulin sensitivity
Nunlee-Bland et al[51]3410-20↓ 25OHD is associated with insulin resistance
Shankar et al[61]12719> 20↓ 25OHD is associated with pre-diabetes state
(C)
Song et al[63]76220meta-analysisinverse relation between 25OHD and risk for T2DM
Afzal et al[64]984148-65↓ 25OHD is associated with ↑ risk for T2DM
Pittas et al[65]95243meta-analysis↓ incidence of T2DM in highest vs lowest 25OHD
Buijsse et al[69]5308850.9HR of T2DM is ↓ with ↑ in 25OHD