Functions of Müller cell-derived vascular endothelial growth factor in diabetic retinopathy

Table 1 Alteration in protein expression/modification in diabetic or hypoxic Müller cell-specific KO mice

Model/time	Proteins/modification	Alteration
STZ-induced diabetes/6 mo	Albumin	Decrease (59%)
STZ-induced diabetes/2 mo	ICAM1	Decrease (62%)
STZ-induced diabetes/2 mo	Nitrotyrosine	Decrease (19%)
STZ-induced diabetes/6 mo	Occludin	Increase (60%)
STZ-induced diabetes/2 mo	pNF-κB p65	Decrease (48%)
STZ-induced diabetes/2 mo	TNF1α	Decrease (53%)
STZ-induced diabetes/6 mo	VEGF	Decrease (51%)
STZ-induced diabetes/6 mo	ZO1	Increase (130%)
Oxygen-induced retinopathy	Albumin	Decrease (56%)
Oxygen-induced retinopathy	VEGF	Decrease (45%)
Oxygen-induced retinopathy	Occludin	Increase (35%)

STZ: Streptozotocin; VEGF: Vascular endothelial growth factor; ICAM1: Intercellular adhesion molecule-1; TNFα: Tumor necrosis factor-α; NF: Nuclear factor; ZO1: Zonula occludens-1.

Table 2 Pathological changes in diabetic or hypoxic Müller cell-specific KO mice

Model	Pathological changes	Alteration
STZ-induced diabetes	Leukocytosis	Decrease (75%)
STZ-induced diabetes	Vascular leakage	Decrease (60%)
STZ-induced diabetes	Acellular capillaries	Decrease (45%)
STZ-induced diabetes	Vascular leakage	Decrease (60.0%)
Oxygen-induced retinopathy	Pre-retinal neovascularization	Decrease (34%)
Oxygen-induced retinopathy	Neovascularization area	Decrease (40%)
Oxygen-induced retinopathy	Vaso-obliteration area	Decrease (30%)

STZ: Streptozotocin.