Copyright
©The Author(s) 2015.
World J Diabetes. Jun 10, 2015; 6(5): 726-733
Published online Jun 10, 2015. doi: 10.4239/wjd.v6.i5.726
Published online Jun 10, 2015. doi: 10.4239/wjd.v6.i5.726
Table 1 Alteration in protein expression/modification in diabetic or hypoxic Müller cell-specific KO mice
Model/time | Proteins/modification | Alteration |
STZ-induced diabetes/6 mo | Albumin | Decrease (59%) |
STZ-induced diabetes/2 mo | ICAM1 | Decrease (62%) |
STZ-induced diabetes/2 mo | Nitrotyrosine | Decrease (19%) |
STZ-induced diabetes/6 mo | Occludin | Increase (60%) |
STZ-induced diabetes/2 mo | pNF-κB p65 | Decrease (48%) |
STZ-induced diabetes/2 mo | TNF1α | Decrease (53%) |
STZ-induced diabetes/6 mo | VEGF | Decrease (51%) |
STZ-induced diabetes/6 mo | ZO1 | Increase (130%) |
Oxygen-induced retinopathy | Albumin | Decrease (56%) |
Oxygen-induced retinopathy | VEGF | Decrease (45%) |
Oxygen-induced retinopathy | Occludin | Increase (35%) |
Table 2 Pathological changes in diabetic or hypoxic Müller cell-specific KO mice
Model | Pathological changes | Alteration |
STZ-induced diabetes | Leukocytosis | Decrease (75%) |
STZ-induced diabetes | Vascular leakage | Decrease (60%) |
STZ-induced diabetes | Acellular capillaries | Decrease (45%) |
STZ-induced diabetes | Vascular leakage | Decrease (60.0%) |
Oxygen-induced retinopathy | Pre-retinal neovascularization | Decrease (34%) |
Oxygen-induced retinopathy | Neovascularization area | Decrease (40%) |
Oxygen-induced retinopathy | Vaso-obliteration area | Decrease (30%) |
- Citation: Wang JJ, Zhu M, Le YZ. Functions of Müller cell-derived vascular endothelial growth factor in diabetic retinopathy. World J Diabetes 2015; 6(5): 726-733
- URL: https://www.wjgnet.com/1948-9358/full/v6/i5/726.htm
- DOI: https://dx.doi.org/10.4239/wjd.v6.i5.726