Simvastatin, atorvastatin, and pravastatin equally improve the hemodynamic status of diabetic rats

Table 1 Blood glucose (mg/dL) in diabetic and control rats treated with statins

Condition	Day 0	Day 1	Day 7	Day 14	Day 28
CT none	131.25 ± 3.14	130.50 ± 1.51	126.78 ± 4.86	112.42 ± 4.55	133.88 ± 13.66
CT + AV	137.0 ± 5.86	123.33 ± 2.85	126.8 ± 2.2	128.40 ± 7.02	180.67 ± 52.21
CT + SV	143.13 ± 1.75	128.50 ± 3.10	126.80 ± 2.22	128.40 ± 7.02	152.88 ± 18.46
CT + PV	142.63 ± 5.79	127.13 ± 3.36	122.20 ± 4.79	120.80 ± 4.47	130.63 ± 4.06
Diabetic none	133.65 ± 3.51	445.41 ± 24.11a	490.45 ± 34.34a	530.09 ± 26.65a	517.76 ± 18.11a
Diabetic + AV	133.00 ± 3.30	473.82 ± 40.23a	497.38 ± 47.68a	485.38 ± 48.73a	500.73 ± 32.65a
Diabetic + SV	133.75 ± 2.70	413.19 ± 21.22a	473.69 ± 27.39a	483.23 ± 39.90a	498.94 ± 30.62a
Diabetic + PV	126.88 ± 2.08	430.44 ± 27.31a	524.38 ± 19.92a	564.85 ± 13.57a	557.25 ± 12.92a

^aP < 0.05 vs age-matched C. Values are means ± SEM. Rats were injected with STZ on day 0. Blood glucose for diabetic rats: n = average of 10 rats per group. AV: Atorvastatin; SV: Simvastatin; PV: Pravastatin; CT: Control; STZ: Streptozotocin.

Table 2 Body weight (g) of diabetic and control rats treated with statins

Condition	Day 0	Day 1	Day 7	Day 14	Day 28
CT none	179.74 ± 4.02	182.28 ± 4.15	242.78 ± 6.18	304.06 ± 13.26	391.34 ± 9.80
CT + AV	167.17 ± 4.38	172.97 ± 4.53	234.77 ± 5.27	287.67 ± 4.67	404.10 ± 12.46
CT + SV	181.89 ± 8.26	184.19 ± 8.12	248.40 ± 7.99	291.69 ± 6.93	394.14 ± 15.92
CT + PV	193.81 ± 8.25	198.85 ± 7.66	262.99 ± 9.03	301.19 ± 8.02	389.64 ± 11.48
Diabetic none	180.22 ± 5.99	172.53 ± 5.24	198.19 ± 7.41	211.94 ± 11.11a	267.10 ± 27.98a
Diabetic + AV	176.30 ± 3.10	159.86 ± 9.93	202.32 ± 5.13	235.45 ± 8.56a	255.40 ± 17.09a
Diabetic + SV	183.14 ± 4.68	178.24 ± 4.29	207.69 ± 6.81	230.13 ± 7.23a	241.65 ± 12.73a
Diabetic + PV	187.88 ± 5.62	182.58 ± 4.60	204.85 ± 7.18	243.69 ± 5.60a	253.99 ± 11.82a

^aP < 0.05 vs age-matched C. Values are means ± SEM. Rats were injected with STZ on day 0. Blood glucose for diabetic rats: n = average of 10 rats per group. STZ: Streptozotocin; AV: Atorvastatin; SV: Simvastatin; PV: Pravastatin; CT: Control.

Table 3 Total cholesterol levels in plasma from diabetic and control rats after four weeks of statin treatment (10 mg/kg per day)

Condition	Cholesterol (mg/dL)
CT none	156.01 ± 7.32
CT + AV	143.69 ± 14.21
CT + SV	169.86 ± 12.78
CT + PV	155.53 ± 7.08
Diabetic none	248.68 ± 15.78a
Diabetic + AV	233.35 ± 18.44a
Diabetic + SV	234.40 ± 12.11a
Diabetic + PV	235.57 ± 18.20a

Values shown are the means ± SEM of an average of 8 animals per group.

^aP < 0.05 vs age-matched treated and untreated CT. AV: Atorvastatin; SV: Simvastatin; PV: Pravastatin; CT: Control.

Table 4 Effect of chronic statin treatment on EC₅₀ and E_MAX values following ach-induced relaxation in diabetic and control rats

Condition	Emax relaxation, %	EC50, μmol/L
CT none	74.61 ± 3.27	0.56 ± 0.11
CT + AV	70.75 ± 3.99	0.68 ± 0.22
CT + SV	70.76 ± 4.16	1.15 ± 0.47
CT + PV	71.16 ± 4.30	0.72 ± 0.20
Diabetic none	53.70 ± 4.07a	0.41 ± 0.10
Diabetic + AV	82.13 ± 7.01c	0.84 ± 0.32
Diabetic + SV	84.63 ± 6.51c	0.40 ± 0.21
Diabetic + PV	83.88 ± 6.83c	0.66 ± 0.35

Values shown are the means ± SEM of an average of 10 animals per group.

^aP < 0.05 when vs age-matched treated and untreated CT;

^cP < 0.05 when vs age-matched untreated diabetic rats. No statistically significant differences were found between treated diabetic rats and treated CT. AV: Atorvastatin; SV: Simvastatin; PV: Pravastatin; CT: Control.